The prognostic significance of uncoupled proliferation and EGFR expression in oral cancer treated with surgery and radiation.

It is common knowledge that apparently similar tumors often show different responses to therapy. This experience has generated the idea that histologically similar tumors could have biologically distinct behaviour. The development of effective therapy therefore, has the explicit challenge of understanding biological behaviour of a tumor. The question is which parameters in a tumor could relate to its biological behaviour ? It is now recognised that the development of malignancy requires an alteration in the program of terminal differentiation in addition to aberrant growth control. In this study therefore, ultrastructural markers that relate to defective terminal differentiation and possibly invasive potential of cells have been identified in human oral leukoplakias, erythroleukoplakias and squamous cell carcinomas of the tongue.

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Prognostic and clinicopathological significance of neutrophil-to-lymphocyte ratio in patients with oral cancer

Bioscience Reports ◽

10.1042/bsr20181550 ◽

2018 ◽

Vol 38 (6) ◽

Cited By ~ 6

Author(s):

Yun Yang ◽

Rongxun Liu ◽

Feng Ren ◽

Rui Guo ◽

Pengfei Zhang

Keyword(s):

Oral Cancer ◽

Meta Analysis ◽

Prognostic Significance ◽

Tumor Stage ◽

Neutrophil To Lymphocyte Ratio ◽

Advanced Tumor Stage ◽

Lymphocyte Ratio ◽

Advanced Tumor ◽

Oral Cancer Patients ◽

Clinicopathological Significance

Objectives: Many studies have examined the prognostic significance of the neutrophil-to-lymphocyte ratio (NLR) in oral cancer; however, the results are contradictory. We, therefore, conducted a meta-analysis aiming to clarify the prognostic value of the NLR in oral cancer patients. Methods: A literature search was conducted in the PubMed, Web of Science, and Embase databases. Stata version 12.0 was used for statistical analysis. Results: A total of 14 studies with 3216 patients were finally included. The results indicated that a high NLR was significantly associated with worse DFS (n=10, HR = 1.73, 95% confidence interval [CI] = 1.44–2.07, P<0.001). Similar results were observed for overall survival (OS) (n=9, HR = 1.61, 95% CI = 1.39–1.86, P<0.001). Moreover, a high NLR was also correlated with lymph node metastasis (n=7, odds ratio [OR] = 1.62, 95% CI = 1.32–1.98, P<0.001), advanced tumor stage (n=7, OR = 2.63, 95% CI = 2.12–3.25, P<0.001), T stage (n=6, OR = 3.22, 95% CI = 2.59–4.01, P<0.001), tumor differentiation (n=5, OR = 1.48, 95% CI = 1.03–2.11, P=0.033), and perineural invasion (n=4, OR = 1.83, 95% CI = 1.4–2.39, P<0.001). However, an elevated NLR was not correlated with gender. Conclusion: This meta-analysis showed that the NLR might be a potential independent prognostic factor in patients with oral cancer.

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Tumor-associated immune aggregates in oral cancer: Their cellular composition and potential prognostic significance

Medical Hypotheses ◽

10.1016/j.mehy.2017.07.017 ◽

2017 ◽

Vol 108 ◽

pp. 17-23 ◽

Cited By ~ 1

Author(s):

Maria Luiza Diniz de Sousa Lopes ◽

Yi Liu ◽

Kelly Yi-Ping Liu ◽

Éricka Janine Dantas da Silveira ◽

Catherine F. Poh

Keyword(s):

Oral Cancer ◽

Prognostic Significance ◽

Cellular Composition ◽

Immune Aggregates

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Immunocytochemical markers in stage I lung cancer: relevance to prognosis.

Journal of Clinical Oncology ◽

10.1200/jco.1997.15.8.2858 ◽

1997 ◽

Vol 15 (8) ◽

pp. 2858-2865 ◽

Cited By ~ 191

Author(s):

U Pastorino ◽

S Andreola ◽

E Tagliabue ◽

F Pezzella ◽

M Incarbone ◽

...

Keyword(s):

Lung Cancer ◽

Multivariate Analysis ◽

Cox Model ◽

Statistical Significance ◽

Prognostic Significance ◽

Stage I ◽

Laminin Receptor ◽

Independent Predictive Factor ◽

Time To Recurrence ◽

Egfr Expression

PURPOSE This study investigated the frequency of the expression and prognostic significance of a panel of immunocytochemical markers in resected non-small-cell lung cancer (NSCLC). PATIENTS AND METHODS A total of 515 cases of pathologic stage I NSCLC were analyzed. The median follow-up time of surviving patients was 102 months. The following immunocytochemical markers were tested: blood group A and precursors of blood antigens; laminin receptor; c-erbB1/epidermal growth factor receptor (EGFR) and c-erbB2/Neu; BCl2; p53; and angiogenesis. Kaplan-Meier estimates of survival and time to recurrence were calculated for clinical variables and biologic markers using the Cox model for multivariate analysis. RESULTS The pathologic tumor extension (pT) represented the most powerful prognostic factor for survival (P = .0008) and time to recurrence (P = .0007). None of the immunocytochemical markers emerged as an independent predictive factor for survival. Bcl2-positive tumors showed a better time to recurrence (P = .03), but the difference lost statistical significance in the multivariate analysis. Of interest, in the group of 137 patients classified as pT1N0, both EGFR expression and nonangiogenic type of vascular pattern were associated with a poorer survival (P = .02). However, data derived from subset analysis must be interpreted cautiously. CONCLUSION Our findings do not support a relevant prognostic role of immunocytochemical markers in NSCLC. The evidence is not sufficient to alter clinical practice or even to restrict clinical trials of adjuvant treatments to predefined biologic subsets of patients.

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