Ultrastructural features of prognostic significance in human oral cancer

It is common knowledge that apparently similar tumors often show different responses to therapy. This experience has generated the idea that histologically similar tumors could have biologically distinct behaviour. The development of effective therapy therefore, has the explicit challenge of understanding biological behaviour of a tumor. The question is which parameters in a tumor could relate to its biological behaviour ? It is now recognised that the development of malignancy requires an alteration in the program of terminal differentiation in addition to aberrant growth control. In this study therefore, ultrastructural markers that relate to defective terminal differentiation and possibly invasive potential of cells have been identified in human oral leukoplakias, erythroleukoplakias and squamous cell carcinomas of the tongue.

Download Full-text

TERT Promoter Mutations and rs2853669 Polymorphism: Useful Markers for Clinical Outcome Stratification of Patients With Oral Cavity Squamous Cell Carcinoma

Frontiers in Oncology ◽

10.3389/fonc.2021.782658 ◽

2021 ◽

Vol 11 ◽

Author(s):

Silvia Giunco ◽

Paolo Boscolo-Rizzo ◽

Enrica Rampazzo ◽

Giancarlo Tirelli ◽

Lara Alessandrini ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Prognostic Significance ◽

Nucleotide Polymorphism ◽

Biological Behaviour ◽

Single Nucleotide ◽

Tert Promoter Mutations ◽

Promoter Mutations ◽

The Impact

ObjectiveTo date, no useful prognostic biomarker exists for patients with oral squamous cell carcinoma (OCSCC), a tumour with uncertain biological behaviour and subsequent unpredictable clinical course. We aim to investigate the prognostic significance of two recurrent somatic mutations (-124 C>T and -146 C>T) within the promoter of telomerase reverse transcriptase (TERT) gene and the impact of TERT single nucleotide polymorphism (SNP) rs2853669 in patients surgically treated for OCSCC.MethodsThe genetic frequencies of rs2853669, -124 C>T and -146 C>T as well as the telomere length were investigated in 144 tumours and 57 normal adjacent mucosal (AM) specimens from OCSCC patients.ResultsForty-five tumours harboured TERT promoter mutations (31.3%), with -124 C>T and -146 C>T accounting for 64.4% and 35.6% of the alterations respectively. Patients with -124 C>T TERT promoter mutated tumours had the shortest telomeres in the AM (p=0.016) and showed higher risk of local recurrence (hazard ratio [HR]:2.75, p=0.0143), death (HR:2.71, p=0.0079) and disease progression (HR:2.71, p=0.0024) with the effect being potentiated by the co-occurrence of T/T genotype of rs2853669.Conclusion-124 C>T TERT promoter mutation as well as the T/T genotype of the rs2853669 SNP are attractive independent prognostic biomarkers in patients surgically treated for OCSCC, with the coexistence of these genetic variants showing a synergistic impact on the aggressiveness of the disease.

Download Full-text

Prognostic significance of epidermal growth factor receptor in esophageal squamous cell carcinomas

Cancer ◽

10.1002/1097-0142(19890601)63:11<2169::aid-cncr2820631117>3.0.co;2-w ◽

1989 ◽

Vol 63 (11) ◽

pp. 2169-2173 ◽

Cited By ~ 112

Author(s):

Soji Ozawa ◽

Masakazu Ueda ◽

Nobutoshi Ando ◽

Nobuyoshi Shimizu ◽

Osahiko Abe

Keyword(s):

Epidermal Growth Factor Receptor ◽

Growth Factor ◽

Epidermal Growth Factor ◽

Squamous Cell ◽

Prognostic Significance ◽

Growth Factor Receptor ◽

Squamous Cell Carcinomas ◽

Esophageal Squamous Cell Carcinomas ◽

Epidermal Growth

Download Full-text

The Majority of Cutaneous Squamous Cell Carcinomas Arise in Actinic Keratoses

Journal of Cutaneous Medicine and Surgery ◽

10.1177/120347540200600301 ◽

2002 ◽

Vol 6 (3) ◽

pp. 207-209 ◽

Cited By ~ 35

Author(s):

D. Czarnecki ◽

C. J. Meehan ◽

F. Bruce ◽

G. Culjak

Keyword(s):

Family History ◽

Squamous Cell ◽

Retrospective Studies ◽

Prognostic Significance ◽

Squamous Cell Carcinomas ◽

Histological Features ◽

Actinic Keratoses ◽

Skin Cancers ◽

History Of ◽

A Prospective Study

Background: Retrospective studies have given conflicting results with respect to how many cutaneous squamous cell carcinomas (SCCs) arise in actinic keratoses (AK). Objective: This study was conducted to determine what percentage of SCCs arise in AKs and to obtain more information about two histological features of SCCs, namely, thickness and ulceration. Methods: A prospective study was done of all SCCs treated by the authors during one calendar year. Results: Two hundred eight patients with SCC were entered into the study. An AK was contiguous with an SCC in 72% of the cases. This was taken as evidence that the SCC arose in the AK. Men presented with thicker and more ulcerated SCCs than women, but these were not statistically significant: p = 0.06 for thickness and p = 0.07 for ulceration. Ulcerated SCCs were more likely to arise on the head and neck (p = 0.02), on patients who had multiple skin cancers ( p = 0.005), and on patients who had a family history of skin cancer ( p = 0.03). Conclusion: Actinic keratoses need to be removed before they turn into SCCs. The prognostic significance of ulceration of cutaneous SCCs needs to be determined.

Download Full-text