Association between cancer-related fatigue and other symptoms in breast cancer patients.

2013 ◽  
Vol 31 (15_suppl) ◽  
pp. e20526-e20526
Author(s):  
Anita Roselyn Peoples ◽  
Charles E. Heckler ◽  
Joseph A. Roscoe ◽  
Charles Stewart Kamen ◽  
Luke Joseph Peppone ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Linear Regression ◽  
Cancer Patients ◽  
Post Treatment ◽  
Cancer Therapies ◽  
Breast Cancer Patients ◽  
Cancer Related Fatigue ◽  
Disturbed Sleep ◽  
Delayed Nausea ◽  
Unit Increase

e20526 Background: Cancer-related fatigue (CRF) is one of the most prevalent side effects of cancer treatment and has a detrimental effect on a patient’s normal functioning and quality of life. At present, the underlying pathophysiology of CRF is poorly understood, as it is complex phenomenon involving the interaction of many factors. The relative contributions of the disease itself, different cancer therapies, and comorbid conditions (e.g., sleep disorders, nausea) remain unclear. Therefore, it is important to understand the association between them in order to develop better strategies for the prevention and treatment of CRF. Methods: The purpose of these secondary analyses was to examine the association between post-treatment fatigue with disturbed sleep (on a 0–10 scale), delayed nausea (on a 1–7 scale), age, and baseline fatigue. Analyses were performed on 541 breast cancer patients (mean age 54, 100% female) who completed a four-day diary assessing nausea and sleep following initial chemotherapy. Fatigue as its worst during the prior week (0 = no fatigue to 10 = fatigue as bad as you can imagine) was assessed both prior to chemotherapy and on Day 4. To determine associations between variables, Pearson’s correlation analysis and linear regression were performed. Results: Post-treatment CRF was significantly associated with baseline fatigue (r = 0.40, p < 0.0001), disturbed sleep (r = 0.45, p < 0.0001), delayed nausea (r = 0.37, p < 0.0001), and age (r = -0.22, p < 0.0001). Linear regression showed that a one unit increase in baseline fatigue, disturbed sleep, and delayed nausea was associated with increase in post-treatment CRF by 0.29, 0.37, and 0.42, respectively, all p’s < 0.0001. In addition, every ten years of increased age was associated with a decrease in post-treatment CRF by 0.33 (p < 0.0013). Conclusions: Post-treatment fatigue was found to be significantly correlated with baseline fatigue, disturbed sleep, and delayed nausea while negatively correlated with age in patients with breast cancer. These results demonstrate the importance of further research to better understand the underlying psychological and biological mechanisms for CRF in order to develop effective treatments. Supported by NCI grant CA37420.

scholarly journals Nausea and disturbed sleep as predictors of cancer-related fatigue in breast cancer patients: a multicenter NCORP study

2016 ◽  
Vol 25 (4) ◽  
pp. 1271-1278 ◽  
Author(s):  
Anita R. Peoples ◽  
Joseph A. Roscoe ◽  
Robert C. Block ◽  
Charles E. Heckler ◽  
Julie L. Ryan ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Breast Cancer Patients ◽  
Cancer Related Fatigue ◽  
Disturbed Sleep

scholarly journals Analysis of Changes in Cancer-Related Fatigue of Breast Cancer Patients Receiving an Integrative Medicine Program

2020 ◽  
Vol 19 ◽  
pp. 153473542096378
Author(s):  
Friedemann Schad ◽  
Anja Thronicke ◽  
Phillipp von Trott ◽  
Shiao Li Oei
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Integrative Medicine ◽  
Regression Analyses ◽  
Breast Cancer Patients ◽  
Point Change ◽  
Cancer Related Fatigue ◽  
Tumor Stages ◽  
Multivariable Regression ◽  
Integrative Medicine Program

Introduction: Cancer-related fatigue (CRF) occurs frequently in breast cancer patients. The aim of this real-world study was to analyze the longitudinal changes of CRF in breast cancer patients receiving an integrative medicine program, which includes the application of non-pharmacological interventions (NPIs) and Viscum album L. (VA) extracts. Methods: All data were collected from the clinical register of the Network Oncology of a German certified breast cancer center of the Gemeinschaftskrankenhaus Havelhöhe (GKH). Primary breast cancer patients, treated upon initial diagnosis with integrated NPIs, comprising art and exercise therapy, nursing interventions, and educational components, during their hospital stay, and who had answered the German Cancer-Fatigue Scale (CFS-D) questionnaire at first diagnosis and 12 months later, were included. The associations between NPIs and CFS-D changes were analyzed with adjusted multivariable regression analyses, considering received treatment regimens and demographic variables, using the software R. Results: 231 female breast cancer patients of all tumor stages were evaluated. While chemotherapy exhibited significant severe deterioration, add-on VA applications seem to partially mitigate this impairment on CRF. 36 separate multivariable regression analyses for all NPIs showed that in particular significant associations between CFS-D improvements and the interventions nursing compresses (6 point change; P = .0002; R² = 28%) or elaborate consultations and life review (ECLR) (4 point change; P = .0002; R² = 25%) were observed. Conclusions: Breast cancer patients benefit from a hospital-based integrative medicine program. To alleviate fatigue symptoms during oncological therapy, an expansion of this concept should be developed in the future.

Immunomodulatory Activities of Yunzhi and Danshen in Post-treatment Breast Cancer Patients

2005 ◽  
Vol 33 (03) ◽  
pp. 381-395 ◽  
Author(s):  
Chun-Kwok Wong ◽  
Yi-Xi Bao ◽  
Eliza Lai-Yi Wong ◽  
Ping-Chung Leung ◽  
Kwok Pui Fung ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Body Weight ◽  
Cancer Patients ◽  
Salvia Miltiorrhiza ◽  
Interleukin 2 ◽  
Post Treatment ◽  
Enzyme Linked Immunosorbent Assay ◽  
Breast Cancer Patients ◽  
T Helper ◽  
The Absolute

Breast cancer is the most common cancer among women worldwide. Discomfort and fatigue are usually arisen from anticancer therapy such as surgery, radiotherapy, chemotherapy, hormonal therapy, or combination therapy, because of the suppressed immunological functions. Yunzhi (Coriolus versicolor) can modulate various immunological functions in vitro, in vivo, and in human clinical trials. Danshen (Salvia miltiorrhiza) has been shown to benefit the circulatory system by its vasodilating and anti-dementia activity. The purpose of this clinical trial was to evaluate the immunomodulatory effects of Yunzhi-Danshen capsules in post-treatment breast cancer patients. Eighty-two patients with breast cancer were recruited to take Yunzhi [50 mg/kg body weight, 100% polysaccharopeptide (PSP)] and Danshen (20 mg/kg body weight) capsules every day for a total of 6 months. EDTA blood samples were collected every 2 months for the investigation of immunological functions. Flow cytometry was used to assess the percentages and absolute counts of human lymphocyte subsets in whole blood. Plasma level of soluble interleukin-2 receptor (sIL-2R) was measured by enzyme-linked immunosorbent assay (ELISA). Results showed that the absolute counts of T-helper lymphocytes (CD4+), the ratio of T-helper (CD4+)/T suppressor and cytotoxic lymphocytes (CD8+), and the percentage and the absolute counts of B-lymphocytes were significantly elevated in patients with breast cancer after taking Yunzhi-Danshen capsules, while plasma sIL-2R concentration was significantly decreased (all p < 0.05). Therefore, the regular oral consumption of Yunzhi-Danshen capsules could be beneficial for promoting immunological function in post-treatment of breast cancer patients.

scholarly journals Application and Effect of the Gymnastic Exercise Mode during Chemotherapy for Breast Cancer Patients

2020 ◽  
Vol 2020 ◽  
pp. 1-9
Author(s):  
Feifei Xie
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Incidence Rate ◽  
Evaluation System ◽  
Malignant Tumors ◽  
Treatment Plan ◽  
Breast Cancer Surgery ◽  
Breast Cancer Patients ◽  
Rehabilitation Training ◽  
Cancer Related Fatigue

Breast cancer is one of the most common malignant tumors in women, which seriously threatens the health of women. With the improvement of living standards, the incidence rate of breast cancer is also rising. In the past ten years, the incidence rate of breast cancer in China’s major cities has increased by 37%, far higher than that in Europe and America. At present, chemotherapy and radiotherapy are the main treatment methods for breast cancer, but many patients will have cancer-related fatigue after surgery. Some studies believe that appropriate sports can improve cancer-related fatigue, but there is no specific research in this area. In view of this problem, this paper puts forward a rehabilitation training method based on gymnastics for breast cancer surgery. This paper is divided into three parts. The first part is the basic theory and core concept of breast cancer and cancer-related fatigue. Through the in-depth study of the theory, this paper believes that breast cancer patients paying attention to rehabilitation training can effectively improve cancer-related fatigue and affect the final therapeutic effect. The second part is the rehabilitation training program based on the way of gymnastics. The corresponding experimental model is established by using real cases as samples. In order to ensure the quality of the experiment, this paper gives the treatment plan in detail and establishes a unified evaluation system. In the third part of this paper, the relevant experiments and results analysis are given, and through data analysis, this paper believes that gymnastics can effectively help breast cancer patients with postoperative rehabilitation and continuous recovery of the upper limb function and improve cancer-related fatigue and other issues.

Cancer-related fatigue and depression in breast cancer patients postchemotherapy: Different associations with optimism and stress appraisals

2014 ◽  
Vol 13 (5) ◽  
pp. 1141-1151 ◽  
Author(s):  
Inbar Levkovich ◽  
Miri Cohen ◽  
Shimon Pollack ◽  
Karen Drumea ◽  
Georgeta Fried
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Physical Symptom ◽  
Multivariate Regression Analysis ◽  
Physical Symptoms ◽  
Breast Cancer Patients ◽  
Life Orientation Test ◽  
Symptoms Of Depression ◽  
Cancer Related Fatigue ◽  
Stress Appraisals

AbstractObjective:Symptoms of depression and cancer-related fatigue (CRF) are common among breast cancer patients postchemotherapy and may seriously impair quality of life (QoL). This study aimed to assess the relationship between depression and CRF in breast cancer patients postchemotherapy and to examine their relationships to optimism and to threat and challenge appraisals.Method:Participants included 95 breast cancer patients (stages 1–3) 1 to 6 months after completion of chemotherapy. Patients submitted personal and medical details and completed the following: physical symptom questionnaires (EORTC QLQ–C30, and QLQ–BR23), a symptoms of depression questionnaire (CES–D), the Fatigue Symptom Inventory (FSI), the Life Orientation Test (LOT–R), and a stress appraisals questionnaire.Results:We found levels of depression, CRF, and appraisals of cancer as a threat to be moderate and levels of optimism and appraisals of cancer as a challenge to be high. Depression and CRF were positively associated. A multivariate regression analysis revealed that 51% of the CRF variance was explained and, together with physical symptoms and threat appraisal, were significantly associated with CRF. A total 67% of depression was explained and, and together with challenge and threat appraisals, were significantly associated with depression.Significance of Results:Although CRF and depression were often experienced simultaneously and both were found to be higher among individuals who gave higher appraisals of cancer as a threat, only depression was related to optimism and challenge appraisals, while CRF was related mainly to intensity of physical symptoms. The different pattern of associations between optimism and appraisals warrants further clinical attention as well as future study.

Measurement of DKK1 and FRP in breast and prostate cancer patients with bone metastases: Impact of zoledronic acid (ZA)

2007 ◽  
Vol 25 (18_suppl) ◽  
pp. 19659-19659
Author(s):  
T. Helsten ◽  
M. Corr ◽  
J. E. Mortimer
Keyword(s):  
Breast Cancer ◽  
Prostate Cancer ◽  
Bone Metastases ◽  
Cancer Patients ◽  
Post Treatment ◽  
Bone Homeostasis ◽  
Breast Cancer Patients ◽  
Bone Specific Alkaline Phosphatase ◽  
Osteoblast Activity ◽  
Breast And Prostate Cancer

19659 Background: Bone metastases produce an imbalance in osteoblast and osteoclast activity. While metastases from prostate cancer are osteoblastic, metastases from breast cancer may be osteolytic, osteoblastic or mixed. The wnt/frizzled pathway is involved in maturation of osteoblasts and in adult bone homeostasis. We explored the wnt antagonists dickkopf (DKK1) and frizzled related protein (FRP) as potential biomarkers in bone metastasis after ZA treatment. Methods: This is a pilot cohort study in bisphosphonate naive breast and prostate cancer patients with bone metastases. Cancer therapy was not specified. Patients received 2 monthly doses of ZA 4 mg IV. Pre- and post-treatment (day 60) sera were collected for measurement of FRP and DKK1, along with IL-6, calcium, creatinine and bone-specific alkaline phosphatase (BAP, a marker of osteoblast activity). Primary endpoint: mean change in FRP and DKK1; Secondary endpoints: correlation of biomarkers with each other and comparison of breast vs. prostate cancer patients. Biomarkers were measured using standard ELISA assays. Statistics: comparison of means = student t-test, correlation coefficients = Pearson. Results: Mature data from 14 patients are reported here, 9 with breast and 5 with prostate cancer. Mean age = 61 years (range 42–89). Two breast cancer patients were premenopausal. One prostate and 3 breast cancer patients received chemotherapy; all others were treated hormonally. After ZA, calcium decreased in all patients (p = 0.09). BAP decreased in all but 1 breast and 1 prostate cancer patient (mean decrease 20.0, p = 0.16). IL-6 was undetectable in most patients. FRP decreased in all but 4 patients (mean decrease 6.2, p = 0.13). There was no discernable pattern for DKK1. Pre-treatment DKK1 correlated with FRP (p = 0.01, r2 = 0.39), but there was no correlation post-treatment. Post-treatment DKK1 correlated with both serum calcium (p = 0.04, r2 = 0.49) and BAP (p = 0.005, r2 = 0.65). There was no difference between breast and prostate cancer patients. Conclusions: It is feasible to measure DKK1 and FRP in patients with malignant bone disease. Treatment with ZA has measurable effects upon these and other serum markers. Further studies with more patients are needed to evaluate their potential as biomarkers. No significant financial relationships to disclose.

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