scholarly journals A Practical Solution for Dyspareunia in Breast Cancer Survivors: A Randomized Controlled Trial

2015 ◽  
Vol 33 (30) ◽  
pp. 3394-3400 ◽  
Author(s):  
Martha F. Goetsch ◽  
Jeong Y. Lim ◽  
Aaron B. Caughey
Keyword(s):  
Breast Cancer ◽  
Sexual Function ◽  
Cancer Survivors ◽  
Breast Cancer Survivors ◽  
Rank Test ◽  
Median Score ◽  
Open Label ◽  
Randomized Controlled ◽  
Sexual Distress ◽  
Distress Scale

Purpose Dyspareunia is common in breast cancer survivors because of low estrogen. This study explored whether dyspareunia is introital pain, preventable with analgesic liquid. Patients and Methods In a randomized, controlled, double-blind trial, estrogen-deficient breast cancer survivors with severe penetrative dyspareunia applied either saline or 4% aqueous lidocaine to the vulvar vestibule for 3 minutes before vaginal penetration. After a 1-month blinded trial of patient-assessed twice-per-week tampon insertion or intercourse, all patients received lidocaine for 2 months in an open-label trial. The primary outcome was patient-related assessment of penetration pain on a scale of zero to 10. Secondary outcomes were sexual distress (Female Sexual Distress Scale), sexual function (Sexual Function Questionnaire), and resumption of intercourse. Comparisons were made with the Mann-Whitney U and Wilcoxon signed rank test with significance set at P < .05. Results In all, 46 patients, screened to exclude those with pelvic muscle and organ pain, uniformly had clinical evidence of severe vulvovaginal atrophy, dyspareunia (median pain score, 8 of 10; interquartile range [IQR], 7 to 9), increased sexual distress scores (median, 30.5; IQR, 23 to 37; abnormal, > 11), and abnormal sexual function. Users of lidocaine reported less pain during intercourse in the blinded phase (median score of 1.0 compared with saline score of 5.3; P = .007). After open-label lidocaine use, 37 (90%) of 41 reported comfortable penetration. Sexual distress decreased (median score, 14; IQR, 3 to 20; P < .001), and sexual function improved in all but one domain. Of 20 prior abstainers from intercourse who completed the study, 17 (85%) had resumed comfortable penetrative intimacy. No partners reported penile numbness. Conclusion Breast cancer survivors with menopausal dyspareunia can have comfortable intercourse after applying liquid lidocaine compresses to the vulvar vestibule before penetration.

scholarly journals Perilla Oil and Bifidobacterium for Alleviating Fear of Cancer Recurrence in Breast Cancer Survivors: Study Protocol for a Three-Arm Phase II Randomized Controlled Study (POB Study)

2021 ◽  
Vol 4 (3) ◽  
pp. 46
Author(s):  
Yohei Sasaki ◽  
Mina Honyashiki ◽  
Takayuki Kinoshita ◽  
Akira Matsui ◽  
Ayako Nakashoji ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Survivors ◽  
Phase Ii ◽  
Study Protocol ◽  
Breast Cancer Survivors ◽  
Cancer Recurrence ◽  
Fear Of Cancer Recurrence ◽  
Randomized Controlled ◽  
Perilla Oil ◽  
Fear Of Cancer

The fear of cancer recurrence (FCR) is the most common and most severe unmet need among cancer survivors. Safe treatments for the FCR that are easily disseminated are greatly needed. Our primary aim is a preliminary evaluation of the efficacy and effect size of perilla oil, which is rich in omega-3 fatty acids, and Bifidobacterium, a probiotic, on FCR in breast cancer survivors after the completion of chemotherapy. This study has been planned as an exploratory clinical study (phase II) and will be conducted as a three-arm, 12-week parallel group, masked-rater randomized controlled trial. Fifteen participants will be randomized with 1:1:1 allocation to receive Bifidobacterium plus perilla oil, Bifidobacterium alone, or no intervention (control). Interventions will end within 12 weeks after the random allocation of each participant. The participants will be outpatients with invasive breast cancer aged 20 years or older whose chemotherapy was completed at least 6 months before registration; hormone therapy may be ongoing. The primary outcome will be severity of FCR at 12 weeks assessed by masked raters using the 4-item Concerns about Recurrence Scale concerning overall fear of recurrence. The study protocol for the current study is registered in the Japan Registry of Clinical Trials (jRCTs031200029).

scholarly journals Impact of an Educational Program on Sexual Issues among Cervical Cancer Survivors' Women in Northern Upper Egypt

2021 ◽  
Vol 5 (1) ◽  
pp. 01-15
Author(s):  
Hanan Elzeblawy Hassan ◽  
Ragaa Mohammed ◽  
Soad Ramadan ◽  
Hagar Masaud
Keyword(s):  
Cervical Cancer ◽  
Sexual Dysfunction ◽  
Sexual Function ◽  
Cancer Survivors ◽  
Educational Program ◽  
Gynecological Cancer ◽  
Upper Egypt ◽  
Sexual Distress ◽  
Distress Scale ◽  
The Impact

Background: Sexuality is an important part of normal human functioning. Gynecological cancer and its treatments can affect one or more phases of the sexual response cycle, through alterations of sexual function. Sexual dysfunction is one of the most distressful symptoms among cervical cancer survivors. Sexual distress is a broad term encompassing any sexual discomfort and dysfunction. Sexual difficulties following cervical cancer can be stressful for couples as it can feel like a core part of the relationship has disappeared. Aim: The study is conducted to evaluate the impact of an educational program on sexual issues (sexual dysfunction & sexual distress) among cervical cancer survivors' women in Northern Upper Egypt. Methods; Design: A quasi-experimental design. Setting: out-patient clinic in the oncology unit at Beni-Suef University Hospital. Subjects: A purposive sample of 70 women. Tools: structured interviewing questionnaire sheet, female sexual function index, and female sexual distress scale. Results: The results of the study revealed regression of all items of women’s sexual distress scores, and progression of all items of women’s sexual items post-program compared to pre-one. Conclusion: The teaching program was very effective in improving sexuality among cervical cancer survivors' women. Recommendations: Disseminate the educational booklet at health centers and oncology outpatients. Integrate psychologist, psychosexual specialist, and social worker in treatment and counseling program for women with cervical cancer in the early stage of their treatment.

scholarly journals Mindfulness meditation for younger breast cancer survivors: A randomized controlled trial

Cancer ◽  
2014 ◽  
Vol 121 (8) ◽  
pp. 1231-1240 ◽  
Author(s):  
Julienne E. Bower ◽  
Alexandra D. Crosswell ◽  
Annette L. Stanton ◽  
Catherine M. Crespi ◽  
Diana Winston ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Randomized Controlled Trial ◽  
Cancer Survivors ◽  
Breast Cancer Survivors ◽  
Mindfulness Meditation ◽  
Controlled Trial ◽  
Randomized Controlled

Patient-reported sexual function of breast cancer survivors with genitourinary syndrome of menopause after fractional CO2 laser therapy

Menopause ◽  
2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Allison M. Quick ◽  
Filadelfiya Zvinovski ◽  
Catherine Hudson ◽  
Andrew Hundley ◽  
Cynthia Evans ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Sexual Function ◽  
Cancer Survivors ◽  
Laser Therapy ◽  
Co2 Laser ◽  
Breast Cancer Survivors ◽  
Genitourinary Syndrome Of Menopause ◽  
Fractional Co2 Laser ◽  
Patient Reported ◽  
Genitourinary Syndrome
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