scholarly journals Twelve-Month Estrogen Levels in Premenopausal Women With Hormone Receptor–Positive Breast Cancer Receiving Adjuvant Triptorelin Plus Exemestane or Tamoxifen in the Suppression of Ovarian Function Trial (SOFT): The SOFT-EST Substudy

2016 ◽  
Vol 34 (14) ◽  
pp. 1584-1593 ◽  
Author(s):  
Meritxell Bellet ◽  
Kathryn P. Gray ◽  
Prudence A. Francis ◽  
István Láng ◽  
Eva Ciruelos ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Luteinizing Hormone ◽  
Ovarian Function ◽  
Follicle Stimulating Hormone ◽  
Premenopausal Women ◽  
First Year ◽  
Prior Chemotherapy ◽  
Time Points ◽  
Time Point ◽  
Stimulating Hormone

Purpose To describe estradiol (E2), estrone (E1), and estrone sulfate (E1S) levels during the first year of monthly triptorelin plus exemestane or tamoxifen and to assess possible suboptimal suppression while receiving exemestane plus triptorelin. Patients and Methods Premenopausal patients with early breast cancer on the Suppression of Ovarian Function Trial who selected triptorelin as the ovarian suppression method and were randomly assigned to exemestane plus triptorelin or tamoxifen plus triptorelin were enrolled until the target population of 120 patients was reached. Blood sampling time points were 0, 3, 6, 12, 18, 24, 36, and 48 months. Serum estrogens were measured with a highly sensitive and specific assay. This preplanned 12-month analysis evaluated E2, E1, E1S, follicle-stimulating hormone, and luteinizing hormone levels in all patients and the proportion of patients with E2 levels greater than 2.72 pg/mL at any time point during treatment with exemestane plus triptorelin. Results One hundred sixteen patients (exemestane, n = 86; tamoxifen, n = 30; median age, 44 years; median E2, 51 pg/mL; 55% prior chemotherapy) started triptorelin and had one or more samples drawn. With exemestane plus triptorelin, median reductions from baseline E2, E1, and E1S levels were consistently ≥ 95%, resulting in significantly lower levels than with tamoxifen plus triptorelin at all time points. Among patients on exemestane plus triptorelin, 25%, 24%, and 17% had an E2 level greater than 2.72 pg/mL at 3, 6, and 12 months, respectively. Baseline factors related to on-treatment E2 level greater than 2.72 pg/mL were no prior chemotherapy (P = .06), higher body mass index (P = .05), and lower follicle-stimulating hormone and luteinizing hormone (each P < .01). Conclusion During the first year, most patients on exemestane plus triptorelin had E2 levels below the defined threshold of 2.72 pg/mL, consistent with levels reported in postmenopausal patients on aromatase inhibitors, but at each time point, at least 17% of patients had levels greater than the threshold.

Laparoscopic Ovarian Transposition Before Pelvic Irradiation: A Saudi Tertiary Center Experience

2010 ◽  
Vol 20 (6) ◽  
pp. 1082-1086 ◽  
Author(s):  
Ismail A. Al-Badawi ◽  
Murad Al-Aker ◽  
Jamal AlSubhi ◽  
Hany Salem ◽  
Alaa Abduljabbar ◽  
...  
Keyword(s):  
Ovarian Function ◽  
Medical Center ◽  
Gynecologic Oncology ◽  
Follicle Stimulating Hormone ◽  
Premenopausal Women ◽  
Pelvic Irradiation ◽  
Ovarian Transposition ◽  
Tertiary Center ◽  
Stimulating Hormone

Objective:To report the authors' experience with laparoscopic ovarian transposition and ovarian function preservation in women who require pelvic irradiation as part of their cancer therapy.Design:Cohort study.Setting:The gynecologic oncology service in a referral tertiary/quaternary medical center in Saudi Arabia.Patients:Twenty-three premenopausal patients treated with radiotherapy for a pelvic malignancy.Interventions:Laparoscopic ovarian transposition to paracolic gutters with uterine conservation.Main Outcome Measures:Preservation of ovarian function assessed by patients' symptoms and serum follicle-stimulating hormone level.Results:Bilateral laparoscopic ovarian transposition was performed in 23 patients: 15 with cervical cancer, 4 with rectal cancer, 3 with Ewing sarcoma, and 1 with Hodgkin lymphoma. No immediate intraoperative or postoperative complications were observed. Three patients were lost to follow-up. Ovarian preservation was achieved in 13 (65%) of 20 patients. Seven patients with low follicle-stimulating hormone levels had regular uterine bleeding at follow-up.Conclusions:Laparoscopic ovarian transposition is a safe and effective procedure for preserving ovarian function. This procedure should be considered in all premenopausal women who need to undergo pelvic irradiation as part of their cancer treatment.

REPTILIAN OVARIAN STEROIDOGENESIS AND THE INFLUENCE OF MAMMALIAN GONADOTROPHINS (FOLLICLE-STIMULATING HORMONE AND LUTEINIZING HORMONE) IN VITRO

1974 ◽  
Vol 62 (2) ◽  
pp. 267-275 ◽  
Author(s):  
S. W. C. CHAN ◽  
I. P. CALLARD
Keyword(s):  
Luteinizing Hormone ◽  
Ovarian Function ◽  
Cholesterol Metabolism ◽  
Ovarian Tissue ◽  
Follicle Stimulating Hormone ◽  
Sampling Period ◽  
Steroid Synthesis ◽  
Stimulating Hormone

SUMMARY The synthesis of steroids from [7α-3H]cholesterol, [7α-3H]pregnenolone and [7α-3H]progesterone by lizard and turtle ovarian tissues in vitro was studied. Progesterone, 17α-hydroxyprogesterone, dehydroepiandrosterone, androstenedione, testosterone, oestrone and oestradiol were identified as products. In the turtle (Pseudemys), conversion of pregnenolone to progesterone was efficient, but transformation of progesterone to other steroids was relatively slow as indicated by the accumulation of progesterone over the incubation period. In Dipsosaurus, accumulation of radioactivity was greatest in testosterone, the quantities of which continued to increase at each sampling period. The rate of utilization of pregnenolone as a substrate was similar for the two species studied and the quantities of oestrone and oestradiol formed were lower in Pseudemys. The use of progesterone as precursor by Dipsosaurus ovarian tissue revealed a similar pattern of Δ4-steroid metabolism to that obtained with pregnenolone as precursor. The effects of addition of purified follicle-stimulating hormone (FSH) and luteinizing hormone (LH) on the metabolism of [14C]cholesterol in vitro was studied using Pseudemys follicular tissue. The pattern of cholesterol metabolism was similar to that for pregnenolone in this species. The synthesis of pregnenolone, progesterone, dehydroepiandrosterone and androstenedione in vitro was significantly enhanced in the presence of LH. Follicle-stimulating hormone had no effect on steroid synthesis except for a decrease of androstenedione formation. The stimulatory effect of LH on steroidogenesis in vitro is discussed in relation to the literature suggesting that mammalian FSH, but not LH, stimulates all phases of reptilian ovarian function when injected in vivo.

Hormonal Study in Patients Developing Amenorrhea during Adjuvant Chemotherapy for Breast Cancer

1979 ◽  
Vol 65 (1) ◽  
pp. 93-97 ◽  
Author(s):  
Camilla Recchione ◽  
Anna Rossi
Keyword(s):  
Breast Cancer ◽  
Adjuvant Chemotherapy ◽  
Luteinizing Hormone ◽  
Premenopausal Women ◽  
Thyroid Stimulating Hormone ◽  
Operable Breast Cancer ◽  
Blood Levels ◽  
Stimulating Hormone

The sera of 15 premenopausal women with operable breast cancer and who had developed amenorrhea during adjuvant chemotherapy with cyclophosphamide+methotrexate+ fluorouracil were analyzed for the following hormones: 17-beta-estradiol, luteinizing hormone, thyroid stimulating hormone and prolactin. The blood levels did not differ significantly from those found in patients operated on for breast cancer and in spontaneous menopause (controls). These results suggest that the amenorrhea induced by CMF chemotherapy is of ovarian origin.

scholarly journals Effect of 3 Months Exercise on Ovarian Reserve and Ovulatory Status of Premenopausal Students of Nnamdi Azikiwe University, Nnewi Campus

2022 ◽  
Vol 12 (1) ◽  
pp. 78-86
Author(s):  
Njoku CM ◽  
Meludu SC ◽  
Dioka CE
Keyword(s):  
Luteinizing Hormone ◽  
Ovarian Reserve ◽  
Follicle Stimulating Hormone ◽  
Premenopausal Women ◽  
Exercise Group ◽  
Enzyme Linked Immunosorbent Assay ◽  
Control Group ◽  
Vigorous Exercise ◽  
Vigorous Intensity ◽  
Stimulating Hormone

There is a traditional believe that if premenopausal women engage in prolonged physical exercise, they are likely to have infertility. This study assessed the effect of prolonged moderate – vigorous exercise on ovarian reserve and ovulatory status in premenopausal students of Nnamdi Azikiwe University, Nnewi Campus. The objectives were to determine the effect of moderate – vigorous intensity exercise on Anti-Mullerian hormone (AMH), day 3 Follicle stimulating hormone (FSH), Luteinizing Hormone (LH), day 3 Estrogen, day 21 Estrogen, and day 21 Progesterone levels in premenopausal women. This was a prospective comparative study involving 80 participants aged between 19 and 25 years, randomly selected and assigned to exercise group and control group. The exercise group comprised 40 participants who engaged in moderate – vigorous intensity exercise using elliptical bike for 30 minutes, five days a week for 3 months; however, 30 individuals completed the exercise. The control group comprised of 40 individuals that did not do exercise but 30 individuals completed the study. Blood (8ml) was collected from each of the participants at baseline, 1 month, 2 months, and 3 months. AMH, FSH, LH, Estrogen and Progesterone levels were analyzed using enzyme- linked Immunosorbent assay (ELISA) method. Results were regarded as significant at p˂ 0.05. In the exercise group, the serum level of day 3 FSH, LH, Estrogen were significantly lower from 7.27±0.77 mIU/ml, 7.00±0.77 mIU/ml, 36.33±5.13 pg/ml respectively at baseline to 5.62±0.48 mIU/ml, 5.36±0.80 mIU/ml, 21.36±4.34 pg/ml respectively after 3 months of exercise while there was significantly higher levels of AMH and day 21 progesterone after 3 months of exercise compared with the baseline and respective control (p<0.05). Prolonged Moderate-to-vigorous exercise may enhance fertility and well-being of premenopausal women. Key words: Anti-Mullerian hormone (AMH), day 3 Follicle stimulating hormone (FSH), Luteinizing Hormone (LH), day 3 Estrogen, day 21 Estrogen, day 21 Progesterone, moderate – vigorous exercise, ovarian reserve, ovulatory status, premenopausal women.

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