Do patients with low-risk (T1-2 [<3 cm] N0, HR+) breast cancer and anti-hormone treatment need adjuvant radiation therapy? A meta-analysis of randomized trials.

2016 ◽  
Vol 34 (15_suppl) ◽  
pp. e12075-e12075
Author(s):  
Christiane Matuschek ◽  
Edwin Boelke ◽  
Kai Kammers ◽  
Wilfried Budach
Keyword(s):  
Breast Cancer ◽  
Radiation Therapy ◽  
Randomized Trials ◽  
Meta Analysis ◽  
Hormone Treatment ◽  
Low Risk ◽  
Adjuvant Radiation ◽  
Treatment Need ◽  
Adjuvant Radiation Therapy

scholarly journals Adjuvant radiation therapy of regional lymph nodes in breast cancer - a meta-analysis of randomized trials- an update

2015 ◽  
Vol 10 (1) ◽  
Author(s):  
Wilfried Budach ◽  
Edwin Bölke ◽  
Kai Kammers ◽  
Peter Arne Gerber ◽  
Carolin Nestle-Krämling ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Radiation Therapy ◽  
Lymph Nodes ◽  
Randomized Trials ◽  
Meta Analysis ◽  
Adjuvant Radiation ◽  
Regional Lymph Nodes ◽  
Adjuvant Radiation Therapy

Fatigue in patients with adjuvant radiation therapy for breast cancer: long-term follow-up

2004 ◽  
Vol 130 (6) ◽  
pp. 327-333 ◽  
Author(s):  
Hans Geinitz ◽  
Frank B. Zimmermann ◽  
Reinhard Thamm ◽  
Monika Keller ◽  
Raymonde Busch ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Radiation Therapy ◽  
Adjuvant Radiation ◽  
Adjuvant Radiation Therapy ◽  
Long Term Follow Up

Adjuvant radiation therapy in young breast cancer patients: current state of the art and evidence-based algorithm

The Breast ◽  
2018 ◽  
Vol 41 ◽  
pp. S15
Author(s):  
Icro Meattini ◽  
Matteo Lambertini ◽  
Isacco Desideri ◽  
Alex De Caluwé ◽  
Orit Kaidar-Person ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Radiation Therapy ◽  
Cancer Patients ◽  
State Of The Art ◽  
Adjuvant Radiation ◽  
Evidence Based ◽  
Breast Cancer Patients ◽  
Adjuvant Radiation Therapy ◽  
Current State ◽  
Young Breast Cancer

Does Locoregional Radiation Therapy Improve Survival in Breast Cancer? A Meta-Analysis

2000 ◽  
Vol 18 (6) ◽  
pp. 1220-1229 ◽  
Author(s):  
Timothy J. Whelan ◽  
Jim Julian ◽  
Jim Wright ◽  
Alejandro R. Jadad ◽  
Mark L. Levine
Keyword(s):  
Breast Cancer ◽  
Radiation Therapy ◽  
Systemic Therapy ◽  
Odds Ratio ◽  
Randomized Trials ◽  
Meta Analysis ◽  
Radical Mastectomy ◽  
Node Positive ◽  
Meta Analyses ◽  
Positive Breast Cancer

PURPOSE: Recent randomized trials in women with node-positive breast cancer who received systemic treatment report that locoregional radiation therapy improves survival. Previous trials failed to detect a difference in survival that results from its use. A systematic review of randomized trials that examine the effectiveness of locoregional radiation therapy in patients treated by definitive surgery and adjuvant systemic therapy was conducted. METHODS: Randomized trials published between 1967 and 1999 were identified through MEDLINE database, CancerLit database, and reference lists of relevant articles. Relevant data was abstracted. The results of randomized trials were pooled using meta-analyses to estimate the effect of treatment on any recurrence, locoregional recurrence, and mortality. RESULTS: Eighteen trials that involved a total of 6,367 patients were identified. Most trials included both pre- and postmenopausal women with node-positive breast cancer treated with modified radical mastectomy. The type of systemic therapy received, sites irradiated, techniques used, and doses of radiation delivered varied between trials. Data on toxicity were infrequently reported. Radiation was shown to reduce the risk of any recurrence (odds ratio, 0.69; 95% confidence interval [CI], 0.58 to 0.83), local recurrence (odds ratio, 0.25; 95% CI, 0.19 to 0.34), and mortality (odds ratio, 0.83; 95% CI, 0.74 to 0.94). CONCLUSION: Locoregional radiation after surgery in patients treated with systemic therapy reduced mortality. Several questions remain on how these results should be translated into current-day clinical practice.

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