Expression of some molecular and biological markers in tissue of squamous cell carcinoma of the vulva.

2016 ◽  
Vol 34 (15_suppl) ◽  
pp. e17034-e17034
Author(s):  
Evgeniya M. Nepomnyashchaya ◽  
Oleg Ivanovich Kit ◽  
Galina Andreevna Nerodo ◽  
Inna Arnoldovna Novikova ◽  
Victoria A. Ivanova ◽  
...  
Lung Cancer ◽  
1997 ◽  
Vol 18 ◽  
pp. 172
Author(s):  
F.D.C. Bernardi ◽  
L. Antonângelo ◽  
R. Beyruti ◽  
T.Y. Takagaki ◽  
P.H.N. Saldiva ◽  
...  

2013 ◽  
Vol 5 (3) ◽  
pp. 141-145 ◽  
Author(s):  
Wioletta Ratajczak-Wrona ◽  
Ewa Jablonska ◽  
Bozena Antonowicz ◽  
Dorota Dziemianczyk ◽  
Stanislawa Zyta Grabowska

Author(s):  
JOSÉ RICARDO SOUSA COSTA ◽  
SABRINA MOURE ◽  
EMERSON FERREIRA HONÓRIO ◽  
MILENE CASTILHOS OLIVEIRA ◽  
SIMONE MÁRCIA DOS SANTOS MACHADO ◽  
...  

2010 ◽  
Vol 124 (6) ◽  
pp. 650-658 ◽  
Author(s):  
P Silva ◽  
N J Slevin ◽  
P Sloan ◽  
H Valentine ◽  
D Ryder ◽  
...  

AbstractObjective:Management of patients with head and neck squamous cell carcinoma is often based on clinical parameters, with little appreciation of the underlying tumour biology. Single biological marker studies fail to acknowledge the complexity of these tumours. Our aim was to define a profile of biological markers associated with outcome.Design:This retrospective study involved consecutive patients with oropharyngeal squamous cell carcinoma treated with primary radiotherapy between 1996 and 2001. Pre-treatment biopsies were used to study the immunohistochemical expression of nine biological markers. Markers were chosen to reflect biologically relevant pathways.Results:Following analysis of nine markers, a profile of two markers was derived (carbonic anhydrase 9 and major vault protein), the co-expression of which conferred a significantly poor probability of locoregional control. The prognostic effect of these biomarkers in combination was greater than their effect individually.Conclusion:Biomarker profiles can be established which highlight large differences in locoregional control. Identifying tumours that express both carbonic anhydrase 9 and major vault protein may facilitate patient selection for more aggressive treatment.


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