MRI-transrectal ultrasound cognitive fusion-targeted transperineal template-guided saturation prostate biopsies in a consecutive cohort of men.

2016 ◽  
Vol 34 (2_suppl) ◽  
pp. 43-43
Author(s):  
Haim Matzkin ◽  
Snir Dekalo ◽  
Nicola J Mabjeesh
Keyword(s):  
Prostate Cancer ◽  
Cancer Detection ◽  
Detection Rate ◽  
Prostate Volume ◽  
Transrectal Ultrasound ◽  
Cognitive Fusion ◽  
Prostate Cancer Detection ◽  
Negative Biopsy ◽  
Psa Density ◽  
Mri Study

43 Background: MRI of the prostate may improve diagnostic accuracy of prostate cancer. Different fusion approaches with transrectal ultrasound images are employed. Objective: To determine the detection rate of prostate cancer in men undergoing transperineal template-guided saturation biopsy (TTSB) with MRI-based cognitive fusion. Methods: Between the years 2010-2015, 164 consecutive men underwent a multiple-core prostate TTSB. Univariable and multivariable logistic regression analyses were used to address the relationship between clinical TTSB parameters and prostate cancer detection rate. Covariates consisted of age, prostate-specific antigen (PSA), prostate volume, PSA density, digital rectal examination findings, existence of suspicious prostate lesions on MRI, number of previous negative biopsy sets, and number of cores taken during TTSB. Results: Mean age was 65 years and mean PSA was 14 ng/ml, mean prostate volume was 63 ml. Seventy percent of patients had at least two previous negative transrectal biopsy series and another 19% had at least one negative biopsy. One-hundred and fourteen patients (70%) underwent prostate MRI prior to the biopsy. The detection rate of prostate cancer among these patients was 46% of which 69% had Gleason score ≥ 7. Men with a suspicious lesion on MRI (n=80) had a detection rate of 50%, compared to 33% in patients with negative MRI study. On multivariate analysis, the most significant independent predictive factor was PSA density (p= 0.001). Other nearly significant parameters were suspicious MRI lesion, prostate volume and suspicious digital examination. Of note, the prostate cancer detection rate among patients with no MRI study prior to TTSB was 26%. Conclusions: Utilizing MRI cognitive fusion approach increases the detection rate of clinically significant prostate cancer (Gleason score ≥ 7). In patients with existing suspicion for prostate cancer after multiple negative standard TRUS-guided biopsies, performing TTSB after taking into consideration the findings on MRI and PSA density will increase dramatically the detection rate of significant disease.

Impact of the type of ultrasound probe on prostate cancer detection rate and characterization in patients undergoing MRI-targeted prostate biopsies using cognitive fusion

2013 ◽  
Vol 32 (4) ◽  
pp. 977-983 ◽  
Author(s):  
Guillaume Ploussard ◽  
Samuel Aronson ◽  
Vincent Pelsser ◽  
Mark Levental ◽  
Maurice Anidjar ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Detection ◽  
Detection Rate ◽  
Cancer Detection Rate ◽  
Ultrasound Probe ◽  
Cognitive Fusion ◽  
Prostate Cancer Detection ◽  
Prostate Biopsies

INFLUENCE OF USING 16-GAUGE NEEDLE ON PROSTATE CANCER DETECTION RATE IN TRANSRECTAL ULTRASOUND-GUIDED PROSTATE BIOPSY

2006 ◽  
Vol 5 (2) ◽  
pp. 312
Author(s):  
G. Inal ◽  
K. Onur ◽  
M. Tas ◽  
V. Oztekin ◽  
M. Kosan ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Detection ◽  
Prostate Biopsy ◽  
Detection Rate ◽  
Transrectal Ultrasound ◽  
Cancer Detection Rate ◽  
Ultrasound Guided ◽  
Prostate Cancer Detection

Transition zone PSA density improves the prostate cancer detection rate both in PSA 4.0–10.0 and 10.1–20.0 ng/ml in Chinese men

2013 ◽  
Vol 31 (6) ◽  
pp. 744-748 ◽  
Author(s):  
Ping Tang ◽  
Wei Du ◽  
Keji Xie ◽  
Xiangrong Deng ◽  
Jingao Fu ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Transition Zone ◽  
Cancer Detection ◽  
Detection Rate ◽  
Cancer Detection Rate ◽  
Chinese Men ◽  
Prostate Cancer Detection ◽  
Psa Density

scholarly journals Zonal adjusted PSA density improves prostate cancer detection rates compared with PSA in Taiwanese males with PSA < 20 ng/mL

2020 ◽  
Author(s):  
Tsung-Hsin Chang ◽  
Wun-Rong Lin ◽  
Wei-Kung Tsai ◽  
Pai-Kai Chiang ◽  
Marcelo Chen ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Detection ◽  
Operating Characteristic ◽  
Demographic Data ◽  
Transrectal Ultrasound ◽  
Roc Curves ◽  
Detection Rates ◽  
Prostate Cancer Detection ◽  
Psa Density ◽  
Taiwanese Men

Abstract Background: The current study aimed to compare the efficacy of transition zone PSA density (TZPSAD) with traditional PSA and PSA density (PSAD), for the diagnosis of prostate cancer (PCa) in Taiwanese males.Methods: Men with PSA between 4.0 and 20.0 ng/mL who underwent a transrectal ultrasound (TRUS) guided prostate biopsy between the studied period were retrospectively identified. The demographic data, PSAD and TZPSAD were calculated in all patients. Receiver operating characteristic (ROC) curves were used to analyze the accuracy of a positive PCa diagnosis.Results: The area under the ROC (AUC) was 0.615, 0.748 and 0.746 for PSA, PSAD and TZPSAD, respectively. The best cut-off of value for TZPSAD in predicting PCa in men with a PSA of 4.0–10.0 ng/ml was 0.367 ng/ml/ml with a sensitivity of 50% and a specificity of 77.5%. In men with a PSA of 10.1–20.0 ng/ml, the best cut-off value was 0.454 ng/ml, with a sensitivity of 74.8% and specificity of 70.9%.Conclusion: The use of TZPSAD can improve the efficiency and specificity of PSA for the diagnosis of PCa in Taiwanese men with PSA 4.0–20.0 ng/ml. TZPSAD efficiency was similar to PSAD but TZPSAD had better cancer specificity.

scholarly journals Zonal adjusted PSA density improves prostate cancer detection rates compared with PSA in Taiwanese males with PSA < 20 ng/mL

2020 ◽  
Author(s):  
Tsung-Hsin Chang ◽  
Wun-Rong Lin ◽  
Wei-Kung Tsai ◽  
Pai-Kai Chiang ◽  
Marcelo Chen ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Detection ◽  
Operating Characteristic ◽  
Demographic Data ◽  
Transrectal Ultrasound ◽  
Roc Curves ◽  
Detection Rates ◽  
Prostate Cancer Detection ◽  
Psa Density ◽  
Taiwanese Men

Abstract Background: The current study aimed to compare the efficacy of transition zone PSA density (TZPSAD) with traditional PSA and PSA density (PSAD), for the diagnosis of prostate cancer (PCa) in Taiwanese males.Methods: Men with PSA between 4.0 and 20.0 ng/mL who underwent a transrectal ultrasound (TRUS) guided prostate biopsy between the studied period were retrospectively identified. The demographic data, PSAD and TZPSAD were calculated in all patients. Receiver operating characteristic (ROC) curves were used to analyze the accuracy of a positive PCa diagnosis.Results: The area under the ROC (AUC) was 0.615, 0.748 and 0.746 for PSA, PSAD and TZPSAD, respectively. The best cut-off of value for TZPSAD in predicting PCa in men with a PSA of 4.0–10.0 ng/ml was 0.367 ng/ml/ml with a sensitivity of 50% and a specificity of 77.5%. In men with a PSA of 10.1–20.0 ng/ml, the best cut-off value was 0.454 ng/ml, with a sensitivity of 74.8% and specificity of 70.9%.Conclusion: The use of TZPSAD may improve the efficacy and specificity of PSA for the diagnosis of PCa in Taiwanese men with PSA 4.0–20.0 ng/ml. TZPSAD efficacy was similar to PSAD but TZPSAD had better specificity.

scholarly journals 10-Year Experience in Performing Saturation Prostate Biopsy

2017 ◽  
Vol 57 (4) ◽  
pp. 430-437
Author(s):  
Luis Gabriel Villarraga ◽  
Jose Gustavo Ramos ◽  
José De La Hoz ◽  
Juan Guillermo Cataño Cataño
Keyword(s):  
Prostate Cancer ◽  
Regression Model ◽  
Cancer Detection ◽  
Prostate Biopsy ◽  
Detection Rate ◽  
Prostate Volume ◽  
Univariate Analysis ◽  
Cancer Detection Rate ◽  
Wilcoxon Test ◽  
Prostate Cancer Detection

Objective: Identify the prostate cancer detection rate in patients in whom underwenta saturation prostate biopsy as a rebiopsy from January 2005 to February 2015 at SanIgnacio Hospital. Materials and methods: In San Ignacio hospital were performedfrom January 2005 to February 2015, 114 saturation biopsies. The investigatorsmade a univariate analysis of the variables. The association between the variable wasevaluated based on the T-test and Wilcoxon test. P < 0.05 was considered statisticallysignificant. Finally, a regression model was performed to predict significant variablesfor prostate cancer. Results: The cancer detection rate using saturation prostate biopsywas 16.7% of which 84% were categorized as significant. A mean of 19 cores wereobtained. There were statistically significant differences between patients with prostatecancer and healthy patients in the number of previous biopsies, number of samples,prostate volume and PSA density. Conclusion: Saturation prostate biopsy in our studyhas a prostate cancer detection rate of 16.7% and 84% of them were significant in thiscohort of patients.

scholarly journals 644 Validation of The Prostate Imaging Reporting and Data System (PIRADS) Tool for Prostate Cancer Detection in A Contemporary British Cohort

2021 ◽  
Vol 108 (Supplement_2) ◽  
Author(s):  
C Desai ◽  
S A Ehsanullah ◽  
A Bhojwani ◽  
A Dhanasekaran
Keyword(s):  
Prostate Cancer ◽  
Cancer Detection ◽  
Detection Rate ◽  
Transrectal Ultrasound ◽  
District General Hospital ◽  
Data System ◽  
Clear Correlation ◽  
Detection Rates ◽  
Prostate Cancer Detection ◽  
Prostate Imaging

Abstract Introduction The European Association of Urology (EAU) recommends multiparametric MRI (mpMRI) prior to prostate biopsy for investigation of prostate cancer (CaP). Specifically, the mpMRI should be reported using the Prostate Imaging Reporting and Data System (PIRADS) tool. Our study aims to externally validate the PIRADS tool over a multi-centre district general hospital. Method Retrospective review was performed on 104 consecutive patients who underwent mpMRI and subsequent cognitive transrectal ultrasound biopsy of prostate (CTRUSB) over an 18-month period. Collected mpMRI data was correlated with Gleason grading obtained through CTRUSB histology. Results On histology findings, a total of 64.4% patients (n = 67) were found to have prostate cancer with a mean PSA density (PSAD) of 0.48. Extremes of the PIRADS scoring tool showed a clear correlation. PIRADS 2 correlated to a 0% prostate cancer detection rate (PSAD 0.16), whereas PIRADS 5 correlated to 93.1% detection rate (PSAD 0.49). However, for PIRADS 3 and 4, prostate cancer detection rates were 49.8% (PSAD 0.25) and 50.9% (PSAD 0.18) respectively. Conclusions Our study substantiates the association of lesions scored as PIRADS 5 with prostate cancer detection. CTRUSB in PIRADS 2 lesions can be safely avoided. For PIRADS 3 and 4 lesions, PSAD should be considered before performing a biopsy.

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