Weight management following endometrial cancer treatment: A pilot trial to evaluate the efficacy of the profile by Sanford program.

2021 ◽  
Vol 39 (15_suppl) ◽  
pp. 12056-12056
Author(s):  
Maria Bell ◽  
Valerie Reed ◽  
Jan Wernisch ◽  
Natalie Papini ◽  
Steve Herrmann

12056 Background: Excess weight and weight gain are risk factors for endometrial cancer and cancer recurrence following treatment for women with endometrial cancer. Conversely, weight loss among women with obesity has been shown to reduce endometrial cancer risk. Intensive behavioral weight management programs may be an effective method to improve health and reduce weight following treatment. Methods: Twenty-two women following endometrial cancer treatment (age = 59.4 ± 11.5; weight = 241.3 ± 46.3; BMI = 40.5 ± 7.8; time since last treatment 19 ± 17.4 months) were enrolled in a behavioral weight management program and followed for 12 months and 28 matched controls (age = 58.4 ± 11.5; weight = 246.9 ± 60.3; BMI = 41.6 ± 8.6) were assessed over 12 months. The program consists of weekly health coaching meetings to discuss nutrition, activity, and behavior change topics. The nutrition plan targets ≥4 cups of vegetables per day, a ‘lean and green’ grocery meal, complimented with meal replacement foods to provide a nutritionally complete meal plan. Cost of participant membership, coaching, and meal replacements were covered for 6 months and available to purchase for months 7-12. Results: The treatment group completed 28.3 ± 14.1 appointments throughout 12 months resulting in an average weight change of -31.2 ± 17.3 pounds (-13.3 ± 7.4%) at 6 months and -36.1 ± 27.6 pounds (-15.3 ± 11.4%) at 12 months (all p<0.001). Controls had a weight change of -3.9 ± 18.4 pounds (-2.3 ± 7.6%) at 12 months which was significantly different than the treatment group (p<0.001). BMI was significantly reduced in the treatment group at 6 months (-4.8 ± 4.5, p<0.001) and 12 months (-5.2 ± 5.9, p<0.001) and significantly different than in the control group at 12 months (-0.9 ± 3.2, p=0.007). Conclusions: This behavioral weight management program with health coaching and structured nutrition provided clinically significant weight loss that was sustained to 12 months. Future research should examine long-term enrollment in the Profile by Sanford program with reduction in endometrial cancer recurrence.[Table: see text]

2021 ◽  
Vol 11 (2) ◽  
pp. 386-394
Author(s):  
Vijaya Surampudi ◽  
Xinkai Zhou ◽  
Chi-Hong Tseng ◽  
David Heber ◽  
Zhaoping Li

Aims: The progression of prediabetes to T2DM can be delayed through diet modification and weight management. However, the intensive lifestyle program is often not covered by medical insurance. This retrospective analysis evaluates the association of a patient self-paid weight management program on an improvement of blood sugar in overweight and obese patients with impaired fasting glucose (IFG). Methods: The medical records of 4634 patients who participated in the self-pay UCLA Weight Management Program were reviewed and 2572 patients met the criteria for this retrospective analysis to examine whether this program was associated with the reversal of IFG over 3 months among 1396 patients with normal fasting glucose (NFG) and 1176 with IFG. Results: The patients with IFG lost comparable amounts of weight (10.5 ± 1.3 kg) at three months, as did the subjects with NFG (10.1 ± 1.3 kg). Fasting blood glucose in the IFG group decreased from 108.49 ± 6.4 to 101.8 ± 9.41 mg/dL (p < 0.0001) after three months. There were also significant reductions in triglycerides, and both systolic and diastolic blood pressure in both groups in association with weight loss. Conclusion: Our medically supervised self-pay multidisciplinary weight management program was associated with reduced fasting blood glucose levels in patients with IFG over three months with comparable weight loss to patients with NFG.


2014 ◽  
Vol 2014 ◽  
pp. 1-12 ◽  
Author(s):  
Christiaan G. Abildso ◽  
Olivier Schmid ◽  
Megan Byrd ◽  
Sam Zizzi ◽  
Alessandro Quartiroli ◽  
...  

Intentional weight loss among overweight and obese adults (body mass index ≥ 25 kg/m2) is associated with numerous health benefits, but weight loss maintenance (WLM) following participation in weight management programming has proven to be elusive. Many individuals attempting to lose weight join formal programs, especially women, but these programs vary widely in focus, as do postprogram weight regain results. We surveyed 2,106 former participants in a community-based, insurance-sponsored weight management program in the United States to identify the pre, during, and post-intervention behavioral and psychosocial factors that lead to successful WLM. Of 835 survey respondents (39.6% response rate), 450 met criteria for inclusion in this study. Logistic regression analyses suggest that interventionists should assess and discuss weight loss and behavior change perceptions early in a program. However, in developing maintenance plans later in a program, attention should shift to behaviors, such as weekly weighing, limiting snacking in the evening, limiting portion sizes, and being physically active every day.


Obesity Facts ◽  
2017 ◽  
Vol 10 (2) ◽  
pp. 76-84 ◽  
Author(s):  
Renate Kruschitz ◽  
Sandra Wallner-Liebmann ◽  
Harald Lothaller ◽  
Maria Luger ◽  
Bernhard Ludvik

2020 ◽  
Vol 185 (5-6) ◽  
pp. e586-e591
Author(s):  
Paulo R Shiroma ◽  
Tina Velasquez ◽  
Timothy J Usset ◽  
John H Wilhelm ◽  
Paul Thuras ◽  
...  

Abstract Introduction Obesity is prevalent among users of Veteran’s Health Administration services, where it is comorbid with depression, post-traumatic stress disorder, type 2 diabetes, cardiovascular disease, colon, and breast cancer. Among obese subjects, severe obesity represents a subpopulation with the highest risk of depression. We investigate the antidepressant effect of a local VA weight management program (Managing Overweight Veterans Everywhere – MOVE) among depressed veterans with severe obesity. Material and Methods In a 10-week prospective pilot study, 14 clinically depressed veterans with severe obesity were recruited from: (1) the 2-week residential based intense MOVE program (IMP) (N = 7) and (2) the 10-week educational module of self-management MOVE program (SMP) (N = 7). Subjects had a Beck Depression Inventory, 2nd edition (BDI-II) score &gt; 12 and BMI &gt; 40 or BMI &gt; 35 with associated to comorbid conditions. Concurrent treatment for depression such as medications or psychotherapy was excluded. The primary efficacy endpoint was the change in BDI-II score form baseline to week 10. Analysis consisted of linear mixed model with baseline BDI-II score as a covariate, and level of MOVE intervention (IMP vs. SMP), time, and time by treatment interaction as fixed effects, and random patient effect. Pearson’s correlation examined the relationships between clinical and demographic variables and change in severity of depression by BDI-II scores. Secondary outcomes include weight loss and energy expenditure. Results The sample was composed by 14 subjects (IMP = 7; SMP = 7) mostly unemployed (N = 9), married (N = 10), mid-aged (mean = 58.2, SD = 8.4), Caucasian (N = 13), male (N = 12), with recurrent depression (N = 11), and a mean overall duration of current depressive episode of 13.5 months (SD = 10.2). Out of 14 participants; seven had a family history of mood disorder, two had previous psychiatric hospitalization, three had a previous suicidal attempt, and eight had a history of substance use disorder. There was a significant decrease in severity of depression among all 14 (F3,36.77 = 5.28; P &lt; 0.01); antidepressant effect favored the IMP compared to SMP at day 12 (F1,15.10 = 9.37, P = 0.01) and week 6 (F2,27.34 = 4.26, P = 0.03), but effect fell short of significance at week 10. The change in severity of depression measured by BDI-II score significantly correlated with total weight loss (r = −0.60; P = 0.04) and daily energy expenditure at 12 days (r = −0.67; P = 0.01), week 6 (r = −0.59; P = 0.03), and week 10 (r = −0.71; P = 0.01). Conclusions Depressed veterans with severe obesity improved their depressive symptoms by participating in the MOVE program. Veterans in the IMP had greater but short-term antidepressant effect as compared to educational intervention for obesity. Future studies with larger sample size may elucidate the underlying mechanisms of weight reduction to improve depression and, more importantly, sustain response among veterans with severe obesity.


2014 ◽  
Vol 46 ◽  
pp. 644
Author(s):  
Matthew Browning ◽  
Cory Lail ◽  
Sarah Malone ◽  
Melanie Bean ◽  
Edmond Wickham ◽  
...  

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