Feasibility study of gallium-68 citrate PET as a bone-tropic imaging biomarker in mCRPC.

31 Background: Transferrin receptor (TFRC) expression is controlled by the PI3K and MYC signaling pathways, which are frequently dysregulated in prostate cancer (PC). Gallium-68 citrate (68Ga-citrate) is an iron biomimetic, which can be used to image PC in a TFRC dependent fashion. We performed a single-center pilot imaging study to investigate the use of 68Ga-citrate PET in patients with metastatic castration-resistant PC (mCRPC). Methods: Following written informed consent, mCRPC patients were prospectively enrolled and underwent 68Ga-citrate PET imaging. Optional metastatic tumor biopsies were undertaken at the time of imaging. Results: 34 mCRPC patients underwent 68Ga-citrate PET imaging. The median age was 67.5 years old. Median duration of castration resistance was 17.5 months; 14.7% of patients were post-docetaxel. Median serum PSA was 35.2 ng/dL. A total of 483 lesions were detected on conventional imaging (CT, 99mTc-HDP) or 68Ga-citrate PET, including 420 osseous and 63 soft tissue (nodal and visceral) lesions (Table). 67.3% of all lesions were detected on 68Ga-citrate PET, including 74.5% of all osseous lesions but only 19.0% of all soft tissue lesions (p<0.0001). Eight (1.7%) lesions were detected on 68Ga-citrate PET imaging only. Per-lesion average SUVmax (SUVmax,avg) was 6.7. Metastatic biopsies of PET avid lesions were performed in 20 patients (59%); adenocarcinoma histology was confirmed in 14 (70%) cases, treatment-emergent small cell neuroendocrine cancer (t-SCNC) in 6 (30%). There was no significant difference in SUVmax,avg between patients with adenocarcinoma or t-SCNC (SUVmax,avg 7.3 vs 7.6, respectively; Table). Serial 68Ga-citrate PET perfomed in a patient with biopsy-confirmed t-SCNC after 2 cycles of carboplatin/cabazitaxel demonstrated an early metabolic response (28.5% decrease in average SUVmax) confirmed on subsequent conventional imaging. Conclusions: 68Ga-citrate PET detects mCRPC bone metastases in patients with biopsy-proven prostatic adenocarcinoma or t-SCNC, distinguishing it from lineage dependent agents such as PSMA tracers. Detection of an early metabolic response in the bone of a treated t-SCNC patient was observed. Further prospective studies are ongoing coupling serial Ga-citrate PET with investigational agents targeting the MYC signaling pathway. Clinical trial information: NCT02391025. [Table: see text]

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Early Metabolic Response at Mid-Radiation Therapy FDG-PET Imaging Predicts Patterns of Treatment Failure in Locally Advanced Oropharyngeal Cancer

International Journal of Radiation Oncology*Biology*Physics ◽

10.1016/j.ijrobp.2018.07.942 ◽

2018 ◽

Vol 102 (3) ◽

pp. e298-e299

Author(s):

R. Liang ◽

N. Zhang ◽

J. Wu ◽

N. Sandhu ◽

E. Pollom ◽

...

Keyword(s):

Radiation Therapy ◽

Treatment Failure ◽

Pet Imaging ◽

Fdg Pet ◽

Oropharyngeal Cancer ◽

Metabolic Response ◽

Locally Advanced ◽

Early Metabolic Response

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Amino Acid PET Imaging of the Early Metabolic Response During Tumor-Treating Fields (TTFields) Therapy in Recurrent Glioblastoma

Clinical Nuclear Medicine ◽

10.1097/rlu.0000000000001942 ◽

2018 ◽

Vol 43 (3) ◽

pp. 176-179 ◽

Cited By ~ 6

Author(s):

Edit Bosnyák ◽

Geoffrey R. Barger ◽

Sharon K. Michelhaugh ◽

Natasha L. Robinette ◽

Alit Amit-Yousif ◽

...

Keyword(s):

Amino Acid ◽

Pet Imaging ◽

Metabolic Response ◽

Recurrent Glioblastoma ◽

Tumor Treating Fields ◽

Amino Acid Pet ◽

Early Metabolic Response

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Early Metabolic Response as a Predictor of Treatment Outcome in Patients With Metastatic Soft Tissue Sarcomas

Anticancer Research ◽

10.21873/anticanres.13243 ◽

2019 ◽

Vol 39 (3) ◽

pp. 1309-1316 ◽

Cited By ~ 5

Author(s):

MYRELLA VLENTERIE ◽

WIM JG OYEN ◽

NEELTJE STEEGHS ◽

INGRID M.E. DESAR ◽

REMY B. VERHEIJEN ◽

...

Keyword(s):

Treatment Outcome ◽

Soft Tissue ◽

Metabolic Response ◽

Soft Tissue Sarcomas ◽

Early Metabolic Response

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Early metabolic response as predictor for treatment outcome of pazopanib in patients with metastatic soft tissue sarcomas (the PREDICT study).

Journal of Clinical Oncology ◽

10.1200/jco.2018.36.15_suppl.11555 ◽

2018 ◽

Vol 36 (15_suppl) ◽

pp. 11555-11555 ◽

Cited By ~ 2

Author(s):

Winette T.A. Van Der Graaf ◽

Myrella Vlenterie ◽

Neeltje Steeghs ◽

Ingrid Desar ◽

Remy B Verheijen ◽

...

Keyword(s):

Treatment Outcome ◽

Soft Tissue ◽

Metabolic Response ◽

Soft Tissue Sarcomas ◽

Predict Study ◽

Early Metabolic Response

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Early metabolic response to continuous daily dosing of sunitinib in soft tissue sarcomas (STS) other than GIST using FDG- PET

Journal of Clinical Oncology ◽

10.1200/jco.2008.26.15_suppl.10529 ◽

2008 ◽

Vol 26 (15_suppl) ◽

pp. 10529-10529 ◽

Cited By ~ 1

Author(s):

A. D. Van den Abbeele ◽

J. T. Yap ◽

I. Rastarhuyeva ◽

T. Akhurst ◽

M. L. Keohan ◽

...

Keyword(s):

Soft Tissue ◽

Fdg Pet ◽

Metabolic Response ◽

Soft Tissue Sarcomas ◽

Early Metabolic Response

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Usefulness of positron emission tomography for differentiating gliomas according to the 2016 World Health Organization classification of tumors of the central nervous system

Journal of Neurosurgery ◽

10.3171/2019.5.jns19780 ◽

2020 ◽

Vol 133 (4) ◽

pp. 1010-1019 ◽

Cited By ~ 4

Author(s):

Hiroaki Takei ◽

Jun Shinoda ◽

Soko Ikuta ◽

Takashi Maruyama ◽

Yoshihiro Muragaki ◽

...

Keyword(s):

Positron Emission Tomography ◽

Pet Imaging ◽

Who Classification ◽

Standardized Uptake Value ◽

Emission Tomography ◽

World Health ◽

Pet Tracers ◽

Positron Emission ◽

Significant Difference ◽

The Mean

OBJECTIVEPositron emission tomography (PET) is important in the noninvasive diagnostic imaging of gliomas. There are many PET studies on glioma diagnosis based on the 2007 WHO classification; however, there are no studies on glioma diagnosis using the new classification (the 2016 WHO classification). Here, the authors investigated the relationship between uptake of 11C-methionine (MET), 11C-choline (CHO), and 18F-fluorodeoxyglucose (FDG) on PET imaging and isocitrate dehydrogenase (IDH) status (wild-type [IDH-wt] or mutant [IDH-mut]) in astrocytic and oligodendroglial tumors according to the 2016 WHO classification.METHODSIn total, 105 patients with newly diagnosed cerebral gliomas (6 diffuse astrocytomas [DAs] with IDH-wt, 6 DAs with IDH-mut, 7 anaplastic astrocytomas [AAs] with IDH-wt, 24 AAs with IDH-mut, 26 glioblastomas [GBMs] with IDH-wt, 5 GBMs with IDH-mut, 19 oligodendrogliomas [ODs], and 12 anaplastic oligodendrogliomas [AOs]) were included. All OD and AO patients had both IDH-mut and 1p/19q codeletion. The maximum standardized uptake value (SUV) of the tumor/mean SUV of normal cortex (T/N) ratios for MET, CHO, and FDG were calculated, and the mean T/N ratios of DA, AA, and GBM with IDH-wt and IDH-mut were compared. The diagnostic accuracy for distinguishing gliomas with IDH-wt from those with IDH-mut was assessed using receiver operating characteristic (ROC) curve analysis of the mean T/N ratios for the 3 PET tracers.RESULTSThere were significant differences in the mean T/N ratios for all 3 PET tracers between the IDH-wt and IDH-mut groups of all histological classifications (p < 0.001). Among the 27 gliomas with mean T/N ratios higher than the cutoff values for all 3 PET tracers, 23 (85.2%) were classified into the IDH-wt group using ROC analysis. In DA, there were no significant differences in the T/N ratios for MET, CHO, and FDG between the IDH-wt and IDH-mut groups. In AA, the mean T/N ratios of all 3 PET tracers in the IDH-wt group were significantly higher than those in the IDH-mut group (p < 0.01). In GBM, the mean T/N ratio in the IDH-wt group was significantly higher than that in the IDH-mut group for both MET (p = 0.034) and CHO (p = 0.01). However, there was no significant difference in the ratio for FDG.CONCLUSIONSPET imaging using MET, CHO, and FDG was suggested to be informative for preoperatively differentiating gliomas according to the 2016 WHO classification, particularly for differentiating IDH-wt and IDH-mut tumors.

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Fixation stability and implant-associated complications in periacetabular osteotomy: a comparison of screw and K-wire fixation

Archives of Orthopaedic and Trauma Surgery ◽

10.1007/s00402-021-04112-7 ◽

2021 ◽

Author(s):

Vincent Justus Leopold ◽

Juana Conrad ◽

Robert Karl Zahn ◽

Christian Hipfl ◽

Carsten Perka ◽

...

Keyword(s):

Soft Tissue ◽

Screw Fixation ◽

Periacetabular Osteotomy ◽

Implant Migration ◽

Major Complications ◽

Significant Difference ◽

Duration Of Surgery ◽

Wire Fixation ◽

Fixation Stability ◽

Screw Group

Abstract Aims The aim of this study was to compare the fixation stability and complications in patients undergoing periacetabular osteotomy (PAO) with either K-wire or screw fixation. Patients and methods We performed a retrospective study to analyze a consecutive series of patients who underwent PAO with either screw or K-wire fixation. Patients who were treated for acetabular retroversion or had previous surgery on the ipsilateral hip joint were excluded. 172 patients (191 hips: 99 K-wire/92 screw fixation) were included. The mean age at the time of PAO was 29.3 years (16–48) in the K-wire group and 27.3 (15–45) in the screw group and 83.9% were female. Clinical parameters including duration of surgery, minor complications (soft tissue irritation and implant migration) and major complications (implant failure and non-union) were evaluated. Radiological parameters including LCE, TA and FHEI were measured preoperatively, postoperatively and at 3-months follow-up. Results Duration of surgery was significantly reduced in the K-wire group with 88.2 min (53–202) compared to the screw group with 119.7 min (50–261) (p < 0.001). Soft tissue irritation occurred significantly more often in the K-wire group (72/99) than in the screw group (36/92) (p < 0.001). No group showed significantly more implant migration than the other. No major complications were observed in either group. Postoperative LCE, TA and FHEI were improved significantly in both groups for all parameters (p = < 0.0001). There was no significant difference for initial or final correction for the respective parameters between the two groups. Furthermore, no significant difference in loss of correction was observed between the two groups for the respective parameters. Conclusion K-wire fixation is a viable and safe option for fragment fixation in PAO with similar stability and complication rates as screw fixation. An advantage of the method is the significantly reduced operative time. A disadvantage is the significantly higher rate of implant-associated soft tissue irritation, necessitating implant removal. Level of evidence III, retrospective trial.

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Soft tissue masses: distribution of entities and rate of malignancy in small lesions

BMC Cancer ◽

10.1186/s12885-020-07769-2 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Felix G. Gassert ◽

Florian T. Gassert ◽

Katja Specht ◽

Carolin Knebel ◽

Ulrich Lenze ◽

...

Keyword(s):

Soft Tissue ◽

Benign Lesion ◽

Maximum Diameter ◽

Histopathological Diagnosis ◽

Tumor Diameter ◽

Mr Images ◽

Tissue Mass ◽

Malignancy Rate ◽

Significant Difference ◽

Soft Tissue Masses

Abstract Background Small soft tissue masses are often falsely assumed to be benign and resected with failure to achieve tumor-free margins. Therefore, this study retrospectively investigated the distribution of histopathologic diagnosis to be encountered in small soft tissue tumors (≤ 5 cm) in a large series of a tertiary referral center. Methods Patients with a soft tissue mass (STM) with a maximum diameter of 5 cm presenting at our institution over a period of 10 years, who had undergone preoperative Magnetic resonance imaging and consequent biopsy or/and surgical resection, were included in this study. A final histopathological diagnosis was available in all cases. The maximum tumor diameter was determined on MR images by one radiologist. Moreover, tumor localization (head/neck, trunk, upper extremity, lower extremity, hand, foot) and depth (superficial / deep to fascia) were assessed. Results In total, histopathologic results and MR images of 1753 patients were reviewed. Eight hundred seventy patients (49.63%) showed a STM ≤ 5 cm and were therefore included in this study (46.79 +/− 18.08 years, 464 women). Mean maximum diameter of the assessed STMs was 2.88 cm. Of 870 analyzed lesions ≤ 5 cm, 170 (19.54%) were classified as superficial and 700 (80.46%) as deep. The malignancy rate of all lesions ≤ 5 cm was at 22.41% (superficial: 23.53% / deep: 22.14%). The malignancy rate dropped to 16.49% (20.79% / 15.32%) when assessing lesions ≤ 3 cm (p = 0.007) and to 15.0% (18.18% / 13.79%) when assessing lesions ≤ 2 cm (p = 0.006). Overall, lipoma was the most common benign lesion of superficial STMs (29.41%) and tenosynovial giant cell tumor was the most common benign lesion of deep STMs (23.29%). Undifferentiated pleomorphic sarcoma was the most common malignant diagnosis among both, superficial (5.29%) and deep (3.57%) STMs. Conclusions The rate of malignancy decreased significantly with tumor size in both, superficial and deep STMs. The distribution of entities was different between superficial and deep STMs, yet there was no significant difference found in the malignancy rate.

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Does soft tissue mobilization assist static stretching to improve hamstring flexibility? A randomized controlled trial

Journal of Complementary and Integrative Medicine ◽

10.1515/jcim-2019-0288 ◽

2020 ◽

Vol 0 (0) ◽

Cited By ~ 1

Author(s):

Shibili Nuhmani

Keyword(s):

Soft Tissue ◽

Controlled Trial ◽

Knee Extension ◽

Repeated Measure ◽

Control Group ◽

Static Stretching ◽

Significant Difference ◽

Hamstring Flexibility ◽

Soft Tissue Mobilization ◽

Experimental Group

AbstractObjectivesObjective of the study is to investigate whether Soft tissue mobilization (STM) can assist with static stretching to improve hamstring flexibly.MethodsThe design of the study was repeated measure design. The study was conducted at the physical therapy laboratory of Jamia Hamdard University, New Delhi. Participants included 78 healthy males with hamstring tightness, randomly assigned to either the control group (static stretching) or the experimental group (STM and static stretching). The experimental group received five sets of four different STM techniques, followed by two sets of 30-s static stretches 3 days per week over the course of 12 weeks. The control group received 5 min of sham ultrasound with an inactive probe prior to static stretching. Active knee extension test (AKE) was the outcome measure.ResultsBoth groups showed significant improvement in AKE compared with the baseline measurements. With ingroup analysis showed a significant difference in AKE across all measured time periods (weeks 4, 8, and 12) with pre-test in both groups (p<0.05). No significant difference in AKE improvement was found between groups (p>0.05).ConclusionThe results of this study show that STM prior to static stretching does not significantly improve hamstring flexibility among healthy individuals. Although this study cannot be generalized, the results may be useful for evidence-based practice in the management of hamstring tightness.

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