Lasting Complete Clinical Response of a Recurring Cutaneous Squamous Cell Carcinoma With MEK Mutation and PIK3CA Amplification Achieved by Dual Trametinib and Metformin Therapy

2022 ◽  
Author(s):  
Éva Remenár ◽  
Róbert Dóczi ◽  
Anna Dirner ◽  
Anna Sipos ◽  
Anita Perjési ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Clinical Response ◽  
Squamous Cell ◽  
Cutaneous Squamous Cell Carcinoma ◽  
Complete Clinical Response ◽  
Metformin Therapy ◽  
Pik3ca Amplification

Ten‐year outcome of curative “exclusive” chemotherapy in N0M0 squamous cell carcinoma of the larynx and pharynx with complete clinical response

Head & Neck ◽  
2019 ◽  
Vol 41 (7) ◽  
pp. 2190-2196 ◽  
Author(s):  
Ollivier Laccourreye ◽  
Grégoire Marret ◽  
François Rubin ◽  
Elizabeth Fabre ◽  
Cécile Badoual ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Clinical Response ◽  
Squamous Cell ◽  
Complete Clinical Response ◽  
Carcinoma Of The Larynx

Chemotherapy alone in laryngeal squamous cell carcinoma

2006 ◽  
Vol 121 (2) ◽  
pp. 143-148 ◽  
Author(s):  
P Bonfils ◽  
J Trotoux ◽  
V Bassot
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Clinical Response ◽  
Induction Chemotherapy ◽  
Squamous Cell ◽  
Invasive Squamous Cell Carcinoma ◽  
Complete Clinical Response ◽  
Significant Difference ◽  
Carcinoma Of The Larynx ◽  
Chemotherapy Protocol

Aims: To evaluate the results of chemotherapy alone in patients with invasive squamous cell carcinoma of the larynx who have achieved a complete clinical response after an induction chemotherapy protocol.Methods: A comparison of results in a group of complete responders managed with a chemotherapy alone protocol, matched with those of an incomplete responder group managed with conventional modalities.Results: The survival rate of the complete responder group was significantly higher than that of the incomplete responder group. No statistically significant difference was noted between the two groups in terms of local failure and nodal recurrence.Conclusion: Our results confirm the fact that chemotherapy alone is a viable option in selected patients with carcinoma of the larynx who have achieved a complete clinical response after an induction chemotherapy protocol. This therapeutic approach allows surgery and/or radiation therapy to be reserved for the management of metachronous second primary tumours.

Complete Clinical Response in Squamous Cell Carcinoma of the Rectum With Liver Metastases

2011 ◽  
Vol 29 (33) ◽  
pp. e806-e808 ◽  
Author(s):  
Salahattin M. Sanal ◽  
Oya N. Sivrikoz ◽  
Inanc Karapolat ◽  
Sedat Karademir
Keyword(s):  
Squamous Cell Carcinoma ◽  
Liver Metastases ◽  
Cell Carcinoma ◽  
Clinical Response ◽  
Squamous Cell ◽  
Complete Clinical Response ◽  
Carcinoma Of The Rectum

scholarly journals Results of conservative treatment of locally advanced larynx squamous cell carcinoma using intraarterial regional polychemotherapy

2021 ◽  
Vol 11 (1) ◽  
pp. 41-50
Author(s):  
D. A. Safarov ◽  
A. M. Mudunov ◽  
B. I. Dolgushin ◽  
A. A. Akhundov ◽  
I. A. Zaderenko ◽  
...  
Keyword(s):  
Overall Survival ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Clinical Response ◽  
Squamous Cell ◽  
Locally Advanced ◽  
Complete Clinical Response ◽  
Study Objective ◽  
Regional Administration ◽  
Larynx Squamous Cell Carcinoma

The study objective is to evaluate the results of organ-preserving treatment of locally advanced larynx squamous cell carcinoma.Materials and methods. Analysis of 28 patients with locally advanced larynx squamous cell carcinoma (stages III-IV) who underwent treatment at the N.N. Blokhin National Medical Research Center of Oncology of the Ministry of Health of Russia between 2017 and 2020 was performed. At the first stage, 2-3 courses of combined inductive polychemotherapy per the DCF scheme with 21-day interval were performed (docetaxel 60 mg/m2, cisplatin 60 mg/m2 intraarterially bolus with detoxication with sodium thiosulfate, 5-fluorouracil 1000 mg/m2/day as 96-hour infusion). The second stage included external beam radiotherapy (60-70 Gy, 2 Gy per day 5 days a week) as monotreatment if complete clinical response after chemotherapy was achieved or with regional administration of cisplatin (60 mg/m2 once per 3 weeks) if after inductive stage full clinical response wasn»t observed.Results. In 20 (71.5 %) patients, complete clinical response was observed after inductive treatment; in 7 (25 %) patients, partial response was observed. Tumor stabilization was detected in 1 (3.5 %) patient. Two-year overall survival was 95.8 ± 4.1 %, progression-free survival was 90.1 ± 6.8 %.Conclusion. The proposed strategy of organ-preserving treatment of stage III-IV larynx cancer with substitution of systemic chemotherapy with regional intraarterial chemotherapy prior to radiotherapy is highly effective from the point of view of direct anti-tumor effect and recurrence-free and overall survival.

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