Chronic erythematous rash on the face

2021 ◽  
pp. 79-102
Author(s):  
Richard Ashton ◽  
Barbara Leppard
Keyword(s):  
2018 ◽  
Vol 29 (2) ◽  
pp. 64-66
Author(s):  
Mohammad Monirul Islam ◽  
Md Azizul Islam ◽  
M Kumrul Hasan ◽  
Md Abdul Latif Khan

A boy of 17 years was brought by his parents with the complaints of aggressive, violent and assaultive behavior towards parents, using abusive language, demanding money, restlessness, irritability, irrelevant talk and sleep disturbance. His urine test for cannabinoid was positive. He was diagnosed as substance use disorder and was treated with olanzapine along with psychotherapy. After few days, he developed fever followed by erythematous rash with pruritus and swelling of the face, eyelids, trunk and extremities with raised serum bilirubin, ALT and alkaline phosphatase. He was diagnosed as DRESS (Drug Reaction with Eosinophilia and Systemic Symptoms), a rare complication of olanzapine. This is a dangerous and life threatening adverse effect. Early diagnosis can reduce its morbidity and mortality.Bang J Psychiatry December 2015; 29(2): 64-66


PEDIATRICS ◽  
1958 ◽  
Vol 21 (5) ◽  
pp. 718-718

The aseptic type of meningitis has been found to be due to a variety of viruses: Poliomyelitis; Coxsackie B virus; and ECHO virus type 6. In the last few years outbreaks of aseptic meningitis associated with a rash and found to be due to ECHO virus type 9 have been reported from various parts of the world. The present report concerns an outbreak of this type in Coventry, England, in the autumn of 1956 and covers 51 cases admitted to hospital. ECHO virus type 9 was isolated from the feces of 19 out of 27 patients so examined. Eighteen of these showed fourfold or greater rises in antibody titer against ECHO virus type 9 during the course of their illness. The illness was characterized by fever of 101 to 10.3°F and the usual signs of meningitis. An erythematous rash was observed in about one-half of the patients. It always involved the face and was frequently limited to the cheeks only. It often spread to the neck, shoulders and upper trunk but was rarely generalized. Occasionally it became petechial and this, with the predominance of polymorphonuclear leukocytes in the cerebrospinal fluid, made occasional confusion with meningococcal meningitis possible. Pleocytosis did not commonly exceed 500/mm3. No complications were observed, convalescence was rapid and recovery was complete in all cases.


1993 ◽  
Vol 111 (1) ◽  
pp. 171-175 ◽  
Author(s):  
J. V. S. Pether ◽  
G. Lloyd

SummaryThe signs and symptoms exhibited by 29 patients with an acute illness in whom antibodies to hantavirus were detected are described. In the severe cases the most striking signs and symptoms were the persistence for 2 or 3 weeks of a severe sore throat with pyrexia that developed early in the illness, followed by swelling of the face, neck and extremities, with arthropathy and prolonged malaise that lasted for months. A macular erythematous rash, hepatomegaly with abnormal liver function tests, and a tendency to haemorrhage was a later feature of the severe cases. Mild cases presented with a variety of signs and symptoms that were very difficult to link together as a syndrome.


Author(s):  
Richard Ashton ◽  
Barbara Leppard
Keyword(s):  

2019 ◽  
Vol 5 (1) ◽  
Author(s):  
Rosa Paola Cerra ◽  
Alberto Castagna ◽  
Laura Greco ◽  
Rosaria Anna Galea ◽  
Maria Lucia Citraro ◽  
...  

Toxic epidermal necrolysis (TEN) or Lyell’s syndrome is a rare but serious potentially fatal autoimmune dermatologic disease. It is characterized by cutaneous damage due to apoptosis of the keratinocytes with consequent dermo-epidermal separation for a >30% extension of the body surface, associated with mucosal lesions. It is due to the activation of the immune system, often following the intake of potentially toxic drugs [antibiotics, antiepileptics, non-steroidal antinflammatory drugs (NSAIDs), allopurinol] or after infection with herpetic viruses or mycoplasma. We describe the case of an 82- year-old man starting therapy of Allopurinol for hyperuricemia. After four days the patient shows an extensive erythematous rash localized to the trunk and upper limbs. The following day the rash also involves the face, tending to the confluence and after another two days, the macules turn into de-epithelized areas because of dermo-epidermal separation and the lesions involve the oral and ocular mucosa, causing dysphagia and difficulty in speaking. He was treated with steroid and antihistamine therapy, suspending the previously undertaken therapy with antibiotic and Allopurinol.


2018 ◽  
Vol 41 ◽  
Author(s):  
Samuel G. B. Johnson

AbstractZero-sum thinking and aversion to trade pervade our society, yet fly in the face of everyday experience and the consensus of economists. Boyer & Petersen's (B&P's) evolutionary model invokes coalitional psychology to explain these puzzling intuitions. I raise several empirical challenges to this explanation, proposing two alternative mechanisms – intuitive mercantilism (assigning value to money rather than goods) and errors in perspective-taking.


1997 ◽  
Vol 161 ◽  
pp. 203-218 ◽  
Author(s):  
Tobias C. Owen

AbstractThe clear evidence of water erosion on the surface of Mars suggests an early climate much more clement than the present one. Using a model for the origin of inner planet atmospheres by icy planetesimal impact, it is possible to reconstruct the original volatile inventory on Mars, starting from the thin atmosphere we observe today. Evidence for cometary impact can be found in the present abundances and isotope ratios of gases in the atmosphere and in SNC meteorites. If we invoke impact erosion to account for the present excess of129Xe, we predict an early inventory equivalent to at least 7.5 bars of CO2. This reservoir of volatiles is adequate to produce a substantial greenhouse effect, provided there is some small addition of SO2(volcanoes) or reduced gases (cometary impact). Thus it seems likely that conditions on early Mars were suitable for the origin of life – biogenic elements and liquid water were present at favorable conditions of pressure and temperature. Whether life began on Mars remains an open question, receiving hints of a positive answer from recent work on one of the Martian meteorites. The implications for habitable zones around other stars include the need to have rocky planets with sufficient mass to preserve atmospheres in the face of intensive early bombardment.


Author(s):  
G.J.C. Carpenter

In zirconium-hydrogen alloys, rapid cooling from an elevated temperature causes precipitation of the face-centred tetragonal (fct) phase, γZrH, in the form of needles, parallel to the close-packed <1120>zr directions (1). With low hydrogen concentrations, the hydride solvus is sufficiently low that zirconium atom diffusion cannot occur. For example, with 6 μg/g hydrogen, the solvus temperature is approximately 370 K (2), at which only the hydrogen diffuses readily. Shears are therefore necessary to produce the crystallographic transformation from hexagonal close-packed (hep) zirconium to fct hydride.The simplest mechanism for the transformation is the passage of Shockley partial dislocations having Burgers vectors (b) of the type 1/3<0110> on every second (0001)Zr plane. If the partial dislocations are in the form of loops with the same b, the crosssection of a hydride precipitate will be as shown in fig.1. A consequence of this type of transformation is that a cumulative shear, S, is produced that leads to a strain field in the surrounding zirconium matrix, as illustrated in fig.2a.


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