Sleep Deprivation And The Immune Response To Pathogenic And Non-Pathogenic Antigens

2019 ◽  
pp. 127-134
Author(s):  
Richard Brown ◽  
Gerald Pang ◽  
Alan J. Husband ◽  
Maurice G. King ◽  
Diane F. Bull
Keyword(s):  
Immune Response ◽  
Sleep Deprivation

scholarly journals The Bidirectional Relationship between Sleep and Immunity against Infections

2015 ◽  
Vol 2015 ◽  
pp. 1-14 ◽  
Author(s):  
Elizabeth G. Ibarra-Coronado ◽  
Ana Ma. Pantaleón-Martínez ◽  
Javier Velazquéz-Moctezuma ◽  
Oscar Prospéro-García ◽  
Mónica Méndez-Díaz ◽  
...  
Keyword(s):  
Immune Response ◽  
Sleep Deprivation ◽  
Endocrine System ◽  
Parasitic Infections ◽  
Sleep Patterns ◽  
Susceptibility To Infection ◽  
Physiological Processes ◽  
Bidirectional Relationship ◽  
Lack Of Sleep ◽  
Function Of Sleep

Sleep is considered an important modulator of the immune response. Thus, a lack of sleep can weaken immunity, increasing organism susceptibility to infection. For instance, shorter sleep durations are associated with a rise in suffering from the common cold. The function of sleep in altering immune responses must be determined to understand how sleep deprivation increases the susceptibility to viral, bacterial, and parasitic infections. There are several explanations for greater susceptibility to infections after reduced sleep, such as impaired mitogenic proliferation of lymphocytes, decreased HLA-DR expression, the upregulation of CD14+, and variations in CD4+ and CD8+ T lymphocytes, which have been observed during partial sleep deprivation. Also, steroid hormones, in addition to regulating sexual behavior, influence sleep. Thus, we hypothesize that sleep and the immune-endocrine system have a bidirectional relationship in governing various physiological processes, including immunity to infections. This review discusses the evidence on the bidirectional effects of the immune response against viral, bacterial, and parasitic infections on sleep patterns and how the lack of sleep affects the immune response against such agents. Because sleep is essential in the maintenance of homeostasis, these situations must be adapted to elicit changes in sleep patterns and other physiological parameters during the immune response to infections to which the organism is continuously exposed.

Selective REM Sleep Deprivation and Its Impact on the Immune Response

2007 ◽  
pp. 167-174
Author(s):  
Javier Velazquez Moctezuma ◽  
José Ángel Rojas Zamorano ◽  
Enrique Esqueda León ◽  
Andrés Quintanar Stephano ◽  
Anabel Jiménez Anguiano
Keyword(s):  
Immune Response ◽  
Sleep Deprivation ◽  
Rem Sleep ◽  
Rem Sleep Deprivation

scholarly journals Sleep deprivation impairs calcium signaling in mouse splenocytes and leads to a decreased immune response

2012 ◽  
Vol 1820 (12) ◽  
pp. 1997-2006 ◽  
Author(s):  
Lisandro Lungato ◽  
Marcos L. Gazarini ◽  
Edgar J. Paredes-Gamero ◽  
Ivarne l.S. Tersariol ◽  
Sergio Tufik ◽  
...  
Keyword(s):  
Immune Response ◽  
Sleep Deprivation ◽  
Calcium Signaling ◽  
Mouse Splenocytes

Effect of extended sleep deprivation on tumor growth in rats

1996 ◽  
Vol 271 (5) ◽  
pp. R1460-R1464 ◽  
Author(s):  
B. M. Bergmann ◽  
A. Rechtschaffen ◽  
M. A. Gilliland ◽  
J. Quintans
Keyword(s):  
Immune Response ◽  
Body Weight ◽  
Tumor Growth ◽  
Sleep Deprivation ◽  
Host Defense ◽  
Tumor Size ◽  
Sleep Time ◽  
In Vivo Model ◽  
Catabolic State

To assess the effect of chronic sleep deprivation on host defense, we observed growth and regression of a subdermal allogenic carcinoma (Walker 256 rat tumor) in rats undergoing 10 days of total sleep deprivation (TSD rats), yoked stimulus control (TSC) rats that were partially sleep deprived, and home cage control (HCC) rats. Tumor size was measured daily. Integrated tumor size was smaller in TSD rats than in both TSC (P = 0.04) and HCC rats (P = 0.0003). Thus host defense against these tumors (as defined by reduction in tumor size) was improved by sleep deprivation. This improvement could be a nonspecific effect, e.g., tumor growth can be inhibited by a catabolic state (dietary restriction). TSD and TSC rats lost body weight, indicating a catabolic state. However, tumor size was not predicted by body weight change, but was predicted by change in sleep time (P = 0.02). Host defense enhancement could alternatively result from enhanced immune response. Early tumor size (5 days) was similar in the three groups, but peaked sooner in TSD rats than in both TSC (P = 0.05) and HCC rats (P = 0.01), leading to large differences in size later. Immune-suppressed rats also showed little difference from HCC rats in early growth but large differences later. Thus host defense in an in vivo model that manifests a systemic immune response can be enhanced by sleep deprivation with timing, which is consistent with an enhancement of the immune response.

Humoral and cellular immune response to a crude exo-antigen and purified keratinase of Microsporum canis in experimentally infected guinea pigs

1999 ◽  
Vol 37 (2) ◽  
pp. 123-129 ◽  
Author(s):  
B. R. Mignon ◽  
T. Leclipteux ◽  
CH. Focant ◽  
A. J. Nikkels ◽  
G. E. PIErard ◽  
...  
Keyword(s):  
Immune Response ◽  
Cellular Immune Response ◽  
Guinea Pigs ◽  
Microsporum Canis ◽  
Cellular Immune

Abstract #418: Effect of Testosterone (T) Replacement with a T-Gel or a New Oral T Formulation (Rextoro) on Selected Biomarkers of Endothelial Injury and Immune Response to Lipids

2015 ◽  
Vol 21 ◽  
pp. 93
Author(s):  
Merrell Magelli ◽  
Ronald Swerdloff ◽  
John Amory ◽  
Gregory Flippo ◽  
Wael Salameh ◽  
...  
Keyword(s):  
Immune Response ◽  
Endothelial Injury

Author response for "Diabetes alters immune response patterns to acute melioidosis in humans"

2019 ◽  
Author(s):  
Barbara Kronsteiner ◽  
Panjaporn Chaichana ◽  
Manutsanun Sumonwiriya ◽  
Kemajitra Jenjaroen ◽  
Fazle Rabbi Chowdhury ◽  
...  
Keyword(s):  
Immune Response ◽  
Author Response ◽  
Response Patterns

The humoral and cellular immune response of sheep against Borna disease virus in endemic and non-endemic areas

2004 ◽  
Vol 146 (4) ◽  
pp. 159-172 ◽  
Author(s):  
D. Müller-Doblies ◽  
S. Baumann ◽  
P. Grob ◽  
A. Hülsmeier ◽  
U. Müller-Doblies ◽  
...  
Keyword(s):  
Immune Response ◽  
Disease Virus ◽  
Cellular Immune Response ◽  
Borna Disease Virus ◽  
Endemic Areas ◽  
Cellular Immune ◽  
Borna Disease

Caffeine and Placebo Expectation

2007 ◽  
Vol 21 (2) ◽  
pp. 91-99 ◽  
Author(s):  
Yunfeng Sun ◽  
Yinling Zhang ◽  
Ning He ◽  
Xufeng Liu ◽  
Danmin Miao
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Sleep Deprivation ◽  
Cognitive Performance ◽  
Cognitive Functions ◽  
Cardiovascular Regulation ◽  
Double Blind ◽  
Positive Effects ◽  
Pressure Tests ◽  
Healthy Males

Abstract. Caffeine placebo expectation seems to improve vigilance and cognitive performance. This study investigated the effect of caffeine and placebo expectation on vigilance and cognitive performance during 28 h sleep deprivation. Ten healthy males volunteered to take part in the double-blind, cross-over study, which required participants to complete five treatment periods of 28 h separated by 1-week wash-out intervals. The treatments were no substance (Control); caffeine 200 mg at 00:00 (C200); placebo 200 mg at 00:00 (P200); twice caffeine 200 mg at 00:00 and 04:00 (C200-C200); caffeine 200 mg at 00:00 and placebo 200 mg at 04:00 (C200-P200). Participants were told that all capsules were caffeine and given information about the effects of caffeine to increase expectation. Vigilance was assessed by a three-letter cancellation test, cognitive functions by the continuous addition test and Stroop test, and cardiovascular regulation by heart rate and blood pressure. Tests were performed bihourly from 00:00 to 10:00 of the second day. Results indicated that C200-P200 and C200-C200 were more alert (p < .05) than Control and P200. Their cognitive functions were higher (p < .05) than Control and P200. Also, C200-P200 scored higher than C200 in the letter cancellation task (p < .05). No test showed any significant differences between C200-P200 and C200-C200. The results demonstrated that the combination of caffeine 200 mg and placebo 200 mg expectation exerted prolonged positive effects on vigilance and cognitive performance.

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