scholarly journals The Bidirectional Relationship between Sleep and Immunity against Infections

2015 ◽  
Vol 2015 ◽  
pp. 1-14 ◽  
Author(s):  
Elizabeth G. Ibarra-Coronado ◽  
Ana Ma. Pantaleón-Martínez ◽  
Javier Velazquéz-Moctezuma ◽  
Oscar Prospéro-García ◽  
Mónica Méndez-Díaz ◽  
...  
Keyword(s):  
Immune Response ◽  
Sleep Deprivation ◽  
Endocrine System ◽  
Parasitic Infections ◽  
Sleep Patterns ◽  
Susceptibility To Infection ◽  
Physiological Processes ◽  
Bidirectional Relationship ◽  
Lack Of Sleep ◽  
Function Of Sleep

Sleep is considered an important modulator of the immune response. Thus, a lack of sleep can weaken immunity, increasing organism susceptibility to infection. For instance, shorter sleep durations are associated with a rise in suffering from the common cold. The function of sleep in altering immune responses must be determined to understand how sleep deprivation increases the susceptibility to viral, bacterial, and parasitic infections. There are several explanations for greater susceptibility to infections after reduced sleep, such as impaired mitogenic proliferation of lymphocytes, decreased HLA-DR expression, the upregulation of CD14+, and variations in CD4+ and CD8+ T lymphocytes, which have been observed during partial sleep deprivation. Also, steroid hormones, in addition to regulating sexual behavior, influence sleep. Thus, we hypothesize that sleep and the immune-endocrine system have a bidirectional relationship in governing various physiological processes, including immunity to infections. This review discusses the evidence on the bidirectional effects of the immune response against viral, bacterial, and parasitic infections on sleep patterns and how the lack of sleep affects the immune response against such agents. Because sleep is essential in the maintenance of homeostasis, these situations must be adapted to elicit changes in sleep patterns and other physiological parameters during the immune response to infections to which the organism is continuously exposed.

scholarly journals Analisis Faktor Gangguan Tidur pada Remaja Usia 16-18 Tahun

2019 ◽  
Author(s):  
Alya Almira Millania Prasetyo
Keyword(s):  
Sleep Deprivation ◽  
Physiological Function ◽  
Sleep Time ◽  
Sleep Patterns ◽  
Human Needs ◽  
Lack Of Sleep ◽  
The Subject ◽  
Function Of Sleep ◽  
Age Range

Sleep is one of human needs. Although the physiological function of sleep is still unknown, a person who experiences sleep deprivation often experiences a decrease in brain, physical and emotional performance which is considered more irritable. Someone who experiences lack of sleep tends to sleep more the next day. So that it can be concluded that the sleep function is as a balance restorer at the center of the neuron. In this study researchers took the subject of adolescents aged 16-18 years because the activities carried out by adolescents with that age range were considered to be quite dense and could affect their sleep time. The method used is by interviewing several teenagers about their sleep patterns. So that from this study we can know what factors influence the sleep time of adolescents ranging in age from 16-18 years

Vitamin D and sleep duration: Is there a bidirectional relationship?

2020 ◽  
Vol 41 (4) ◽  
Author(s):  
Maryam Mosavat ◽  
Aisling Smyth ◽  
Diana Arabiat ◽  
Lisa Whitehead
Keyword(s):  
Vitamin D ◽  
Sleep Duration ◽  
Vitamin D Supplementation ◽  
The Body ◽  
Bone Homeostasis ◽  
Limited Information ◽  
Physiological Processes ◽  
Vitamin D Levels ◽  
Bidirectional Relationship ◽  
Sleep Length

AbstractVitamin D contributes to numerous physiological processes within the body but primarily calcium and bone homeostasis. Emerging evidence highlights a novel role for vitamin D in maintaining and regulating optimal sleep. Sleep is a known regulator of bone health, highlighting the interconnectedness between vitamin D concentrations, sleep duration and bone metabolism. It is possible that the relationship between sleep length and vitamin D is bidirectional, with vitamin D playing a role in sleep health and conversely, sleep affecting vitamin D levels. Nevertheless, limited information on the direction of the interaction is available, and much remains to be learned concerning the complex relationship between insufficient sleep duration and vitamin D deficiency. Given the potential to implement interventions to improve sleep and vitamin D supplementation, understanding this relationship further could represent a novel way to support and improve health.

scholarly journals Macromolecule biosynthesis: a key function of sleep

2007 ◽  
Vol 31 (3) ◽  
pp. 441-457 ◽  
Author(s):  
Miroslaw Mackiewicz ◽  
Keith R. Shockley ◽  
Micah A. Romer ◽  
Raymond J. Galante ◽  
John E. Zimmerman ◽  
...  
Keyword(s):  
Gene Expression ◽  
Cerebral Cortex ◽  
Sleep Deprivation ◽  
Expression Patterns ◽  
State Level ◽  
Altered Expression ◽  
Mouse Cerebral Cortex ◽  
Genes Encoding ◽  
Function Of Sleep ◽  
Cellular Components

The function(s) of sleep remains a major unanswered question in biology. We assessed changes in gene expression in the mouse cerebral cortex and hypothalamus following different durations of sleep and periods of sleep deprivation. There were significant differences in gene expression between behavioral states; we identified 3,988 genes in the cerebral cortex and 823 genes in the hypothalamus with altered expression patterns between sleep and sleep deprivation. Changes in the steady-state level of transcripts for various genes are remarkably common during sleep, as 2,090 genes in the cerebral cortex and 409 genes in the hypothalamus were defined as sleep specific and changed (increased or decreased) their expression during sleep. The largest categories of overrepresented genes increasing expression with sleep were those involved in biosynthesis and transport. In both the cerebral cortex and hypothalamus, during sleep there was upregulation of multiple genes encoding various enzymes involved in cholesterol synthesis, as well as proteins for lipid transport. There was also upregulation during sleep of genes involved in synthesis of proteins, heme, and maintenance of vesicle pools, as well as antioxidant enzymes and genes encoding proteins of energy-regulating pathways. We postulate that during sleep there is a rebuilding of multiple key cellular components in preparation for subsequent wakefulness.

scholarly journals Heavy metal intoxication compromises the host cytokine response in Ascaris Suum model infection

2016 ◽  
Vol 53 (1) ◽  
pp. 14-23 ◽  
Author(s):  
E. Dvorožňáková ◽  
M. Dvorožňáková ◽  
J. Šoltys
Keyword(s):  
Heavy Metal ◽  
Immune Response ◽  
Ascaris Suum ◽  
Cytokine Response ◽  
Parasitic Infections ◽  
Tnf Α ◽  
Ifn Γ ◽  
High Level ◽  
Larval Burden ◽  
Heavy Metal Intoxication

SummaryLead (Pb), Cadmium (Cd) and Mercury (Hg) are recognized for their deleterious effect on the environment and immunity where subsequently compromised immune response affects the susceptibility to the potential parasitic infections. This study examined the host cytokine response after heavy metal intoxication (Pb, Cd, and Hg) and subsequent Ascaris suum infection in BALB/c mice. Pb modulated murine immune response towards the Th2 type of response (delineated by IL-5 and IL-10 cytokine production) what was also dominant for the outcome of A. suum infection. Chronic intoxication with Pb caused a more intensive development of the parasite infection. Cd stimulated the Th1 immune response what was associated with increase in IFN-γ production and reduction of larvae present in the liver of intoxicated mice. The larval burden was also low in mice intoxicated with Hg. This was probably not related to the biased Th1/Th2 type of immune response, but rather to the bad host conditions caused by mercury toxicity and high level of pro-cachectic cytokine TNF-α.

Manipulation of the immune response in parasitic infections

Parasitology ◽  
1984 ◽  
Vol 88 (4) ◽  
pp. 665-675
Author(s):  
J.G. Howard
Keyword(s):  
Immune Response ◽  
Inbred Mouse ◽  
Lymphocyte Subset ◽  
Mouse Strains ◽  
Parasitic Infections ◽  
Research Experience ◽  
Relevant Research ◽  
Fresh Insight ◽  
Insight Into

The following brief survey considers various manoeuvres which can be applied to manipulate the immune response to parasitic infectionsin vivo. The examples quoted largely concern malaria, babesiosis, schistosomiasis and leishmaniasis, predominantly in inbred mouse strains. Since my own relevant research experience has been restricted to leishmaniasis, this will receive undue emphasis, although it does illustrate particularly well points I wish to stress. The types of intervention described do not all provide the precision of interpretation with which they are sometimes credited. Thus, effects of immunosuppression or T-cell depletion alone can usually only implicate the specific immune response (in its broad sense) in shaping the natural history and outcome of an infection or in underlying the effect of prophylactic immunization. Nevertheless, more precise delineation of lymphocyte subset involvement can be obtained by cell replacement studies in some of these models or by exclusion of antibody. The outcomes of these approaches have been (or are) predictable in most cases. More fascinating, however, are the various instances which will be stressed where totally unpredicted and contrary observations have been made which led (or may lead) to fresh insight into the disease. These serendipitous findings illustrate at the same time the value of applying the manoeuvres, even though they imply that the logical immunologist cannot yet always outsmart the parasite by design.

Sleep Deprivation And The Immune Response To Pathogenic And Non-Pathogenic Antigens

2019 ◽  
pp. 127-134
Author(s):  
Richard Brown ◽  
Gerald Pang ◽  
Alan J. Husband ◽  
Maurice G. King ◽  
Diane F. Bull
Keyword(s):  
Immune Response ◽  
Sleep Deprivation

Endocrine autoimmunity

2011 ◽  
pp. 34-44 ◽  
Author(s):  
Matthew J. Simmonds ◽  
Stephen C. L. Gough
Keyword(s):  
Immune Response ◽  
Type 1 Diabetes ◽  
Immune System ◽  
Endocrine System ◽  
Graves Disease ◽  
Self Tolerance ◽  
Autoimmune Attack ◽  
Endocrine Organs

Dysfunction within the endocrine system can lead to a variety of diseases with autoimmune attack against individual components being some of the most common. Endocrine autoimmunity encompasses a spectrum of disorders including, e.g., common disorders such as type 1 diabetes, Graves’ disease, Hashimoto’s thyroiditis, and rarer disorders including Addison’s disease and the autoimmune polyendocrine syndromes type 1 (APS 1) and type 2 (APS 2) (see Table 1.6.1). Autoimmune attack within each of these diseases although aimed at different endocrine organs is caused by a breakdown in the immune system’s ability to distinguish between self and nonself antigens, leading to an immune response targeted at self tissues. Investigating the mechanisms behind this breakdown is vital to understand what has gone wrong and to determine the pathways against which therapeutics can be targeted. Before discussing how self-tolerance fails, we first have to understand how the immune system achieves self-tolerance.

Analysis of Sleep Deprivation Effect to Driving Performance Using ReactionTest Simulation

2015 ◽  
Vol 72 (4) ◽  
Author(s):  
Ika Nurlaili Isnainiyah ◽  
Febriliyan Samopa ◽  
Hatma Suryotrisongko ◽  
Edwin Riksakomara
Keyword(s):  
Sleep Deprivation ◽  
Traffic Accidents ◽  
Driving Simulator ◽  
Driving Performance ◽  
Deprivation Condition ◽  
Falling Asleep ◽  
Sleep Condition ◽  
Lack Of Sleep ◽  
The Difference ◽  
Social Habits

Sleep deprivation condition might lead to falling asleep through inappropriate situations, such as driving. Driving in a state of fatigue or drowsy from lack of sleep will be far worse than driving after alcohol consumption. Hence, the authors develop a driving simulator using Java to modify the control and rules of OpenDS application in order to simulate and calculate the automatic ReactionTest for 25 respondents simulating in both normal conditions and sleepy conditions when driving. Through this study, the authors obtained that the difference of driving performance in terms of reaction rate when driving the car in sleep deprivation condition and the normal condition, is equal to 1.08 seconds. The results also shown that the risk of loss of control that can occur to the driver of the car in units of meters (m), is equal to 0.3024 x the car’s speed. This study aims to reduce the number of traffic accidents caused by sleep deprivation that occur in society by giving a recommendation to the driver that forced to drive in lack of sleep condition. In top of that, the authors propose to create an understanding for changing the social habits of driving toward a better way.  

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