High-speed rail is gaining momentum worldwide in many countries in the world including the United States and especially in the state of California, Florida, and Texas currently. Focusing on the list of topics below would enable readers including professionals, policy-makers, leaders, staff, academicians, scholars, and students to explore assignments and research into innovative ideas, plans, and strategies related to high-speed rail in the U.S. The chapter presents a list of topics that includes case studies, research questions, projects, and other suggestions to stimulate further research and explore assignments into more optimal formulation and implementation of high-speed rail for the U.S. in the future.