The changing ratio of modal curvature is proposed for damage recognition, and its ability of damage localization and damage quantitative has been studied in this paper. For testing the effect of damage recognition, two research parameters, the different section rigidity and the scope of damages, are included. And changing rules of the index with structure rigidity, constraints, and structure supporting system have been studied at the same time. The numerical analysis results indicated: The relation of linear increase exists between the changing ratio of modal curvature and the extent of damage, the changing slope of the index is bigger with the increase of damage extent; The boundary condition and the structure supporting system will affect the value of index; In the view of one special structure, case study should be carried to establish the relationship between value of index and the extent of damage.
Targeting Protein-Protein Interactions in the DNA Damage Response Pathways for Cancer Chemotherapy
