scholarly journals Synergistic activation of p53-dependent transcription by two cooperating damage recognition pathways

Oncogene ◽  
2000 ◽  
Vol 19 (34) ◽  
pp. 3829-3839 ◽  
Author(s):  
Jeremy P Blaydes ◽  
Ashley L Craig ◽  
Maura Wallace ◽  
H Mei-Ling Ball ◽  
Nicola J Traynor ◽  
...  
Keyword(s):  
Damage Recognition ◽  
Synergistic Activation

scholarly journals Targeting Protein-Protein Interactions in the DNA Damage Response Pathways for Cancer Chemotherapy

2021 ◽  
Author(s):  
Kerry Silva McPherson ◽  
Dmitry Korzhnev
Keyword(s):  
Dna Damage ◽  
Dna Damage Response ◽  
Protein Interactions ◽  
Cell Cycle Progression ◽  
Protein Protein Interactions ◽  
Cycle Progression ◽  
Damage Recognition ◽  
Damage Response ◽  
Cellular Dna ◽  
Dna Damage Recognition

Cellular DNA damage response (DDR) is an extensive signaling network that orchestrates DNA damage recognition, repair and avoidance, cell cycle progression and cell death. DDR alternation is a hallmark of...

scholarly journals Synergistic activation of the type I adenylyl cyclase by Ca2+ and Gs-coupled receptors in vivo.

1994 ◽  
Vol 269 (41) ◽  
pp. 25400-25405
Author(s):  
G A Wayman ◽  
S Impey ◽  
Z Wu ◽  
W Kindsvogel ◽  
L Prichard ◽  
...  
Keyword(s):  
Adenylyl Cyclase ◽  
Type I ◽  
Synergistic Activation

Damage Quantitative Investigation of Beam Structure Based on Changing Ratio of Modal Curvature

2011 ◽  
Vol 255-260 ◽  
pp. 654-658
Author(s):  
Ji Ping Ge
Keyword(s):  
Linear Increase ◽  
Beam Structure ◽  
Quantitative Investigation ◽  
Supporting System ◽  
Damage Recognition ◽  
Modal Curvature ◽  
Damage Extent ◽  
Extent Of Damage ◽  
The Relationship

The changing ratio of modal curvature is proposed for damage recognition, and its ability of damage localization and damage quantitative has been studied in this paper. For testing the effect of damage recognition, two research parameters, the different section rigidity and the scope of damages, are included. And changing rules of the index with structure rigidity, constraints, and structure supporting system have been studied at the same time. The numerical analysis results indicated: The relation of linear increase exists between the changing ratio of modal curvature and the extent of damage, the changing slope of the index is bigger with the increase of damage extent; The boundary condition and the structure supporting system will affect the value of index; In the view of one special structure, case study should be carried to establish the relationship between value of index and the extent of damage.

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