Plant Stanol Ester as a Cholesterol-Lowering Ingredient of Benecol® Foods

2005 ◽  
Author(s):  
Pia Salo ◽  
Anu Hopia ◽  
Jari Ekblom ◽  
Ritva Lahtinen ◽  
Päivi Laakso
Keyword(s):  
Cholesterol Lowering ◽  
Plant Stanol Ester ◽  
Plant Stanol ◽  
Stanol Ester

scholarly journals Optimal Use of Plant Stanol Ester in the Management of Hypercholesterolemia

Cholesterol ◽  
2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Susanna Rosin ◽  
Ilkka Ojansivu ◽  
Aino Kopu ◽  
Malin Keto-Tokoi ◽  
Helena Gylling
Keyword(s):  
Functional Foods ◽  
Ldl Cholesterol ◽  
Daily Intake ◽  
Full Potential ◽  
Cholesterol Reduction ◽  
Cholesterol Lowering ◽  
Plant Stanol Ester ◽  
Plant Stanol ◽  
Reduce Serum Cholesterol ◽  
Stanol Ester

Plant stanol ester is a natural compound which is used as a cholesterol-lowering ingredient in functional foods and food supplements. The safety and efficacy of plant stanol ester have been confirmed in more than 70 published clinical studies and the ingredient is a well-established and widely recommended dietary measure to reduce serum cholesterol. Daily intake of 2 g plant stanols as plant stanol ester lowers LDL-cholesterol by 10%, on average. In Europe, foods with added plant stanol ester have been on the market for 20 years, and today such products are also available in many Asian and American countries. Despite the well-documented efficacy, the full potential in cholesterol reduction may not be reached if plant stanol ester is not used according to recommendations. This review therefore concentrates on the optimal use of plant stanol ester as part of dietary management of hypercholesterolemia. For optimal cholesterol lowering aiming at a lower risk of cardiovascular disease, plant stanol ester should be used daily, in sufficient amounts, with a meal and in combination with other recommended dietary changes.

Plant Stanol Ester as a Cholesterol-Lowering Ingredient of Benecol® Foods

2019 ◽  
pp. 699-730
Author(s):  
Pia Salo ◽  
Anu Hopia ◽  
Jari Ekblom ◽  
Ritva Lahtinen ◽  
Päivi Laakso
Keyword(s):  
Cholesterol Lowering ◽  
Plant Stanol Ester ◽  
Plant Stanol ◽  
Stanol Ester

scholarly journals Cereal-Based Snack Bar with Added Plant Stanol Ester (Benecol®) Consumed between Meals Lowers Serum Total and LDL Cholesterol Effectively in Mildly to Moderately Hypercholesterolemic Subjects

Cholesterol ◽  
2018 ◽  
Vol 2018 ◽  
pp. 1-9 ◽  
Author(s):  
Essi Sarkkinen ◽  
Mari Lyyra ◽  
Sakari Nieminen ◽  
Päivi Kuusisto ◽  
Ingmar Wester
Keyword(s):  
Ldl Cholesterol ◽  
Hdl Cholesterol ◽  
Double Blind ◽  
Cholesterol Lowering ◽  
Plant Stanol Ester ◽  
Parallel Design ◽  
Plant Stanol ◽  
Habitual Diet ◽  
Stanol Ester ◽  
Hypercholesterolemic Subjects

The cholesterol-lowering effect of foods with added plant sterols or stanols consumed as snacks might be compromised. The purpose of this study was to confirm the cholesterol-lowering efficacy of a specially formulated cereal-based snack bar with added plant stanol ester (1.6 g plant stanols/day) when consumed between meals twice a day. In a double-blind, placebo-controlled, 4-week parallel-design study, 71 mildly to moderately hypercholesterolemic subjects were randomized into one of two groups, stanol or placebo group. Subjects were advised to replace their ordinary snacks with test products in an isocaloric manner and otherwise keep their habitual diet unchanged. The study showed that a snack bar product with added plant stanol ester lowered LDL and non-HDL cholesterol by 8.6% and 9.2% (mean%-change), respectively, as compared to the placebo product. The change in LDL cholesterol was statistically significantly different (P=0.001) between the groups while the change in HDL cholesterol or triglycerides did not differ between the groups. In conclusion, the cereal-based snack bar with added plant stanol ester ingested without a meal reduced LDL cholesterol significantly without affecting HDL cholesterol or triglyceride concentrations in mildly hypercholesterolemic men and women. The study is registered as NCT03284918.

scholarly journals Low-Fat Nondairy Minidrink Containing Plant Stanol Ester Effectively Reduces LDL Cholesterol in Subjects with Mild to Moderate Hypercholesterolemia as Part of a Western Diet

Cholesterol ◽  
2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
Maarit Hallikainen ◽  
Johan Olsson ◽  
Helena Gylling
Keyword(s):  
Intervention Group ◽  
Hdl Cholesterol ◽  
Western Diet ◽  
Control Group ◽  
Low Fat ◽  
Cholesterol Lowering ◽  
Plant Stanol Ester ◽  
Plant Stanols ◽  
Plant Stanol ◽  
Stanol Ester

The cholesterol-lowering efficacy of plant stanol ester (STAEST) added to fat- or milk-based products is well documented. However, their efficacy when added to nondairy liquid drinks is less certain. Therefore, we have investigated the cholesterol-lowering efficacy of STAEST added to a soymilk-based minidrink in the hypercholesterolemic subjects. In a randomized, double-blind, placebo-controlled parallel study, the intervention group (n=27) consumed 2.7 g/d of plant stanols as the ester in soymilk-based minidrink (65 mL/d) with the control group (n=29) receiving the same drink without added plant stanols once a day with a meal for 4 weeks. Serum total, LDL, and non-HDL cholesterol concentrations were reduced by 8.0, 11.1, and 10.2% compared with controls (P<0.05 for all). Serum plant sterol concentrations and their ratios to cholesterol declined by 12–25% from baseline in the STAEST group while the ratio of campesterol to cholesterol was increased by 10% in the controls (P<0.05 for all). Serum precursors of cholesterol remained unchanged in both groups. In conclusion, STAEST-containing soymilk-based low-fat minidrink consumed once a day with a meal lowered LDL and non-HDL cholesterol concentrations without evoking any side effects in subjects consuming normal Western diet. The clinical trial registration number is NCT01716390.

scholarly journals Cholesterol lowering efficacy of plant stanol ester in a new type of product matrix, a chewable dietary supplement

2017 ◽  
Vol 30 ◽  
pp. 119-124 ◽  
Author(s):  
Kirsi Laitinen ◽  
Helena Gylling ◽  
Leena Kaipiainen ◽  
Markku J. Nissinen ◽  
Piia Simonen
Keyword(s):  
Dietary Supplement ◽  
Cholesterol Lowering ◽  
Plant Stanol Ester ◽  
Product Matrix ◽  
Plant Stanol ◽  
New Type ◽  
Stanol Ester

scholarly journals Cholesterol Lowering Effect of Plant Stanol Ester Yoghurt Drinks with Added Camelina Oil

Cholesterol ◽  
2016 ◽  
Vol 2016 ◽  
pp. 1-12 ◽  
Author(s):  
Pia Salo ◽  
Päivi Kuusisto
Keyword(s):  
Ldl Cholesterol ◽  
Double Blind ◽  
Cholesterol Lowering ◽  
Plant Stanol Ester ◽  
Camelina Oil ◽  
Plant Stanols ◽  
Lowering Effect ◽  
Plant Stanol ◽  
Stanol Ester ◽  
Cholesterol Lowering Effect

The aim of this study was to investigate the effects of yoghurt minidrinks containing two doses of plant stanol ester either with or without added camelina oil on the serum cholesterol levels in moderately hypercholesterolemic subjects. In this randomised, double-blind, parallel group study, 143 subjects consumed a 65 mL minidrink together with a meal daily for four weeks. The minidrink contained 1.6 or 2.0 grams of plant stanols with or without 2 grams of alpha-linolenic acid-rich camelina oil. The placebo minidrink did not contain plant stanols or camelina oil. All plant stanol treated groups showed statistically significant total, LDL, and non-HDL cholesterol lowering relative to baseline and relative to placebo. Compared to placebo, LDL cholesterol was lowered by 9.4% (p<0.01) and 8.1% (p<0.01) with 1.6 g and 2 g plant stanols, respectively. With addition of Camelina oil, 1.6 g plant stanols resulted in 11.0% (p<0.01) and 2 g plant stanols in 8.4% (p<0.01) reduction in LDL cholesterol compared to placebo. In conclusion, yoghurt minidrinks with plant stanol ester reduced serum LDL cholesterol significantly and addition of a small amount of camelina oil did not significantly enhance the cholesterol lowering effect. This trial was registered with ClinicalTrials.gov NCT02628990.

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