Prenatal stress influences human fetal development and birth outcomes

2005 ◽  
pp. 29-46 ◽  
Author(s):  
Pathik Wadhwa ◽  
Ilona Federenko
Keyword(s):  
Birth Outcomes ◽  
Prenatal Stress ◽  
Fetal Development ◽  
Stress Influences ◽  
Human Fetal Development

scholarly journals Maternal prenatal stress phenotypes associate with fetal neurodevelopment and birth outcomes

2019 ◽  
Vol 116 (48) ◽  
pp. 23996-24005 ◽  
Author(s):  
Kate Walsh ◽  
Clare A. McCormack ◽  
Rachel Webster ◽  
Anita Pinto ◽  
Seonjoo Lee ◽  
...  
Keyword(s):  
Social Support ◽  
Birth Outcomes ◽  
Prenatal Stress ◽  
System Development ◽  
Caloric Intake ◽  
Nervous System Development ◽  
Stressed Group ◽  
Data Driven Approach ◽  
Stress Influences ◽  
Maternal Prenatal Stress

Maternal prenatal stress influences offspring neurodevelopment and birth outcomes including the ratio of males to females born; however, there is limited understanding of what types of stress matter, and for whom. Using a data-driven approach with 27 variables from questionnaires, ambulatory diaries, and physical assessments collected early in the singleton pregnancies of 187 women, 3 latent profiles of maternal prenatal stress emerged that were differentially associated with sex at birth, birth outcomes, and fetal neurodevelopment. Most women (66.8%) were in the healthy group (HG); 17.1% were in the psychologically stressed group (PSYG), evidencing clinically meaningful elevations in perceived stress, depression, and anxiety; and 16% were in the physically stressed group (PHSG) with relatively higher ambulatory blood pressure and increased caloric intake. The population normative male:female secondary sex ratio (105:100) was lower in the PSYG (2:3) and PHSG (4:9), and higher in the HG (23:18), consistent with research showing diminished male births in maternal stress contexts. PHSG versus HG infants were born 1.5 wk earlier (P < 0.05) with 22% compared to 5% born preterm. PHSG versus HG fetuses had decreased fetal heart rate–movement coupling (P < 0.05), which may indicate slower central nervous system development, and PSYG versus PHSG fetuses had more birth complications, consistent with previous findings among offspring of women with psychiatric illness. Social support most strongly differentiated the HG, PSYG, and PHSG groups, and higher social support was associated with increased odds of male versus female births. Stress phenotypes in pregnant women are associated with male vulnerability and poor fetal outcomes.

Prenatal stress and models explaining risk for psychopathology revisited: Generic vulnerability and divergent pathways

2018 ◽  
Vol 30 (3) ◽  
pp. 1041-1062 ◽  
Author(s):  
Anja C. Huizink ◽  
Susanne R. de Rooij
Keyword(s):  
Prenatal Stress ◽  
Fetal Development ◽  
Developmental Psychopathology ◽  
Maternal Stress ◽  
Prenatal Maternal Stress ◽  
Maternal Malnutrition ◽  
Stress Effects ◽  
Underlying Mechanisms ◽  
Stress Influences ◽  
New Evidence

AbstractThe present review revisits three hypothesized models that potentially could explain how prenatal maternal stress influences fetal development, birth outcomes, and subsequent developmental psychopathology. These models were mostly based on animal models, and new evidence for these models from human studies is evaluated. Furthermore, divergent trajectories from prenatal exposure to adversities to offspring affected outcomes are reviewed, including the comparison of studies on prenatal maternal stress with research on maternal substance use and maternal malnutrition during pregnancy. Finally, new directions in research on the mechanism underlying prenatal stress effects on human offspring is summarized. While it is concluded that there is abundant evidence for the negative associations between prenatal maternal stress and offspring behavioral, brain, and psychopathological outcomes in humans, there is no consistent evidence for specific mechanisms or specific outcomes in relation to stress exposure in utero. Rather, principles of multifinality and equifinality best describe the consequences for the offspring, suggesting a generic vulnerability and different pathways from prenatal adversities to developmental psychopathology, which complicates the search for underlying mechanisms. New and promising directions for research are provided to get a better understanding of how prenatal stress gets under the skin to affect fetal development.

Differences in the kinetics of the mineralization process in endochondral and intramembranous osteogenesis in human fetal development

2009 ◽  
Vol 3 (5) ◽  
pp. 533-539 ◽  
Author(s):  
A. Dziedzic-Goclawska ◽  
J. Emerich ◽  
W. Grzesik ◽  
W. Stachowicz ◽  
J. Michalik ◽  
...  
Keyword(s):  
Fetal Development ◽  
Mineralization Process ◽  
Kinetics Of ◽  
Human Fetal Development

scholarly journals Human Fetal Development And The Ways Of Asthabrata As An Idea In The Creation Of Sinjang Batik Tulis

2020 ◽  
Vol 1 (2) ◽  
pp. 96-106
Author(s):  
Danang Priyanto ◽  
FP Sri Wuryani
Keyword(s):  
Fetal Development ◽  
Human Life ◽  
Human Beings ◽  
The Moon ◽  
Development Stages ◽  
The Sublime ◽  
The Creation ◽  
The Universe ◽  
Human Fetal Development ◽  
Full Protection

Human beings which are wired as leaders should live based on the practice of transcendent value and total clarity on noble deeds. It functions as a guideline in living to avoid the crisis of morality that often occurs today. One of the values in this leadershipquality is the teaching of asthabrata containing the noble deeds of a leader who symbolized in the elements of the universe: the fire, the ground, the water, the air, the moon, the clouds, the sun, and the stars. The stage of human fetal development occurs from the age of one to nine months. These stages, along with the teachings of asthabrata become the base of an idea in the creation of batik art. The idea comes from the question of how to process the development stages of human fetal and ways of asthabrata as a base on creating the batik artwork which conveys sublime values about leadership. The purpose of this batik artwork creation are:incorporating the concept of human fetal development as part of human life cycle with the tradition of batik; Conveying the sublime sublime of leadership based on the asthabrata which refers to human nature as a natural born leader. The creation processcovering the method of design exploration, design process, and batik as a result of design by establishing the combination ofhuman fetal development and the asthabrata. The result shows nine sinjang batik tulis artworks, covering; Hamasesa Tan Pilih Warna (manage without seeing the color), Sukci (sacred), Hanguripi Sagung Dumadi (give strength to all life), Girise Kang Samya Miyat (be who you want to see), Sorota Hayem Angayomi (make peaceful and full protection), Jembar Tanpa Pagut(sincerity without limit), Muntir Tan Ana Pedhote (infinite rotation), Panengeraning Keblad (signpost), and Ngudi Kasampurnan(sharpening perfection). 

Anesthesia for Neonatal Myelomeningocele

2021 ◽  
pp. 209-214
Author(s):  
Anna Clebone
Keyword(s):  
Spinal Cord ◽  
Cerebrospinal Fluid ◽  
Spina Bifida ◽  
Neural Tube ◽  
Fetal Development ◽  
Vertebral Column ◽  
Bony Defect ◽  
Spinal Nerves ◽  
Spina Bifida Aperta ◽  
Human Fetal Development

Myelomeningocele, also known as spina bifida aperta (often shortened to the nonspecific name “spina bifida”) is a congenital disorder of the spine. In infants with a myelomeningocele, the neural tube has not closed, and the vertebral arches have not fused during development, leading to spinal cord and meningeal herniation through the skin. Because of the high potential for injury and infection of the exposed spinal cord, which could lead to lifetime disability, these lesions are typically repaired within 24 to 48 hours after birth. A myelomeningocele occurs before day 28 of human fetal development and is an abnormality in which the posterior neural tube closes incompletely. The outcome is a vertebral column deformity, through which the meningeal-lined sac herniates. After the bony defect is created, the hypothesized mechanism of meningeal herniation is that the pulsations of cerebrospinal fluid act progressively to balloon out the spinal cord. If the sac is filled with spinal nerves or the spinal cord, it is known as a myelomeningocele; if the sac is empty, it is called a meningocele.

scholarly journals Adverse Effects of Trichothiodystrophy DNA Repair and Transcription Gene Abnormalities on Human Fetal Development

2009 ◽  
Author(s):  
Roxana Moslehi ◽  
Caroline Signore ◽  
James Troendle ◽  
Amiran Dzutsev ◽  
James Mills
Keyword(s):  
Dna Repair ◽  
Adverse Effects ◽  
Fetal Development ◽  
Human Fetal Development
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