819 Orofacial Clefts and Associated Congenital Anomalies: The 18 Years Experience of a Multidisciplinary Group in a Tertiary Hospital in Portugal

Background. In the hospital of La Princesa, the “Sepsis Code” (CSP) began in 2015, as a multidisciplinary group that provides health personnel with clinical, analytical and organizational tools, with the aim of the detection and early treatment of patients with sepsis. The objective of this study is to evaluate the impact of CSP implantation on mortality and to determine the variables associated with an increase in it. Material and methods. A retrospective analytical study of patients with CSP alert activation from 2015 to 2018 was conducted. Clinical-epidemiological variables, analytical parameters, and severity factors such as admission to critical care units (UCC) and the need for amines were collected. Statistical significance was established at p < 0.05. Results. We included 1,121 patients. The length of stay was 16 days and 32% required admission to UCC. Mortality showed a statistically significant linear downward trend from 24% in 2015 to 15% in 2018. The predictive mortality variables with statistically significant association were lactate > 2 mmol/L, creatinine > 1.6 mg/dL and the need for amines. Conclusions. The implementation of Sepsis Code decreases the mortality of patients with sepsis and septic shock. The presence of a lactate > 2 mmol/L, creatinine > 1.6 mg/dL and/or the need to administer amines in the first 24 hours, are associated with an increase in mortality in the patient with sepsis.

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Epidemiology of orofacial clefts in a Danish county over 35 years – Before and after implementation of a prenatal screening programme for congenital anomalies

European Journal of Medical Genetics ◽

10.1016/j.ejmg.2018.05.016 ◽

2018 ◽

Vol 61 (9) ◽

pp. 489-492 ◽

Cited By ~ 3

Author(s):

Eva Berenth Paaske ◽

Ester Garne

Keyword(s):

Congenital Anomalies ◽

Prenatal Screening ◽

Screening Programme ◽

Orofacial Clefts ◽

Before And After

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Data Quality Assessment on Congenital Anomalies in Ontario, Canada

Frontiers in Pediatrics ◽

10.3389/fped.2020.573090 ◽

2020 ◽

Vol 8 ◽

Author(s):

Qun Miao ◽

Aideen M. Moore ◽

Shelley D. Dougan

Keyword(s):

Data Quality ◽

Congenital Anomalies ◽

Kappa Statistics ◽

Discharge Abstract Database ◽

Ontario Health Insurance Plan ◽

Orofacial Clefts ◽

Great Vessels ◽

Icd 10 ◽

Future Data ◽

Birth Records

Background: Congenital anomalies (CAs) are a major cause of infant morbidity and mortality in Canada. Reliably identifying CAs is essential for CA surveillance and research. The main objective of this study was to assess the agreement of eight sentinel anomalies including: neural tube defects (NTD), orofacial clefts, limb deficiency defects (LDD), Down syndrome (DS), tetralogy of Fallot (TOF), gastroschisis (GS), hypoplastic left heart syndrome (HLHS) and transposition of great vessels (TGA) captured in the BORN Information System (BIS) database and the Canadian Institute for Health Information (CIHI) Discharge Abstract Database (DAD).Methods: Live birth and stillbirth records between the BIS and CIHI-DAD in the fiscal years of 2012–2013 to 2015–2016 were linked using 10 digit infant Ontario Health Insurance Plan (OHIP) numbers. Percent agreement and Kappa statistics were performed to assess the reliability (agreement) of CAs identified in the linked BIS and CIHI-DAD birth records. Then, further investigations were conducted on those CA cases identified in the CIHI-DAD only.Results: Kappa coefficients of the eight selected CAs between BIS (“Confirmed” or “Suspected” cases) and CIHI-DAD were 0.96 (95% CI: 0.93–0.98) for GS; 0.81 (95% CI: 0.78–0.83) for Orofacial clefts; 0.75 (95% CI: 0.72–0.77) for DS; 0.71 (95% CI: 0.65–0.77) for TOF; 0.62 (95% CI: 0.55–0.68) for TGA; 0.59 (95% CI: 0.49–0.68) for HLHS, 0.53 (95% CI: 0.46–0.60) for NTD-all; and 0.30 (95% CI: 0.23–0.37) for LDD.Conclusions: The degree of agreement varied among sentinel CAs identified between the BIS and CIHI. The potential reasons for discrepancies include incompleteness of capturing CAs using existing picklist values, especially for certain sub-types, incomplete neonatal special care data in the BIS, and differences between clinical diagnosis in the BIS and ICD-10-CA classification in the DAD. A future data abstraction study will be conducted to investigate the potential reasons for discrepancies of CA capture between two databases. This project helps quantify the quality of CA data collection in the BIS, enhances understanding of CA prevalence in Ontario and provides direction for future data quality improvement activities.

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P148 – 1835 Chromosomal microarrays testing in children and adolescents with autism spectrum disorder or cognitive impairment associated or not with congenital anomalies: Experience of a tertiary hospital

European Journal of Paediatric Neurology ◽

10.1016/s1090-3798(13)70327-1 ◽

2013 ◽

Vol 17 ◽

pp. S93-S94

Author(s):

R Rocha ◽

M Sampaio ◽

A Castro ◽

F Flor de Lima ◽

M Rodrigues ◽

...

Keyword(s):

Autism Spectrum Disorder ◽

Cognitive Impairment ◽

Children And Adolescents ◽

Congenital Anomalies ◽

Tertiary Hospital ◽

Autism Spectrum ◽

Spectrum Disorder ◽

Adolescents With Autism ◽

Chromosomal Microarrays

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Incidence of Orofacial Clefts in Kumasi, Ghana

ISRN Plastic Surgery ◽

10.5402/2013/280903 ◽

2013 ◽

Vol 2013 ◽

pp. 1-6 ◽

Cited By ~ 1

Author(s):

P. Agbenorku ◽

M. Yore ◽

K. A. Danso ◽

C. Turpin

Keyword(s):

Cleft Palate ◽

Congenital Anomalies ◽

Cleft Lip ◽

Cleft Lip And Palate ◽

Orofacial Clefts ◽

Female Ratio ◽

Live Births ◽

Male Female Ratio ◽

Cleft Lip Palate ◽

History Of

Background. Cleft lip and cleft palate are among the most common orofacial congenital anomalies. This study is to establish Orofacial Clefts Database for Kumasi, Ghana, with a view to extend it to other cities in future to obtain a national orofacial anomaly database. Methods. A descriptive prospective survey was carried out at eleven selected health facilities in Kumasi. Results. The total number of live births recorded was 27,449. Orofacial anomalies recorded were 36, giving an incidence of 1.31/1000 live births or 1 in 763 live births. The mean maternal age of cleft lip/palate babies was 29.85 years (range 18–40 years). The male : female ratio for the orofacial anomalies babies was 1.3 : 1; the male : female ratio was 0.5 : 1 in the cleft lip group, 1.3 : 1 in the cleft lip and palate group, and 4 : 1 in the cleft palate group. The majority of clefts were unilateral (69.4%, n=25), with females (n=14) outnumbering males (n=11). A family history of cleft was recorded with five babies (13.9%). Associated congenital anomalies were recorded in seven (19.4%) cleft lips and/or palates. Conclusion. The incidence of 1 in 763 live births found in this study indicates that cleft lip/palate is a common congenital anomaly in Kumasi.

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The Role of Paternal Age and Occurrence of Orofacial Clefts in South Indian Population

Journal of Evolution of Medical and Dental Sciences ◽

10.14260/jemds/2021/504 ◽

2021 ◽

Vol 10 (31) ◽

pp. 2465-2469

Author(s):

Soumi Samuel ◽

Rajendra Prasad B. ◽

Thara Chandran ◽

Deeyah Miriam Deepak ◽

Shaji Thomas ◽

...

Keyword(s):

Congenital Anomalies ◽

Vital Role ◽

Paternal Age ◽

Control Group ◽

South Indian Population ◽

Age Group ◽

Orofacial Cleft ◽

Orofacial Clefts ◽

South Indian

BACKGROUND The association between orofacial cleft and parental age is evident. This study focuses on paternal age playing a vital role in the birth of children with orofacial clefts. We wanted to assess the role of paternal age as a factor in the development of congenital anomalies in this study. METHODS A case control study was performed on 1000 cases and 250 controls in Mangalore. The parents were interviewed regarding their age at the time of conception. RESULTS 46.4 % of fathers of the cleft children belonged to 30 - 34 years of age group and 25 % belonged to 25 - 29 years of age group at the time of conception. In the control group, 38 % belonged to 30 - 34 years of age group and 24.8 % belonged to 25 - 29 years of age group. CONCLUSIONS Paternal age in the age group of 30 - 34 years has significant contribution in the birth of orofacial children with cleft deformities. KEY WORDS Orofacial cleft, Paternal Age, Congenital anomalies

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Stability of Orofacial Clefting Rate in Alberta, 1980–2011

The Cleft Palate-Craniofacial Journal ◽

10.1597/13-340 ◽

2014 ◽

Vol 51 (6) ◽

pp. 113-121 ◽

Cited By ~ 4

Author(s):

R. Brian Lowry ◽

Barbara Sibbald ◽

Tanya Bedard

Keyword(s):

Folic Acid ◽

Cleft Palate ◽

Congenital Anomalies ◽

Cleft Lip ◽

Folic Acid Supplementation ◽

Multiple Sources ◽

Orofacial Clefts ◽

Folic Acid Fortification ◽

Orofacial Clefting ◽

The Impact

Objective To determine the prevalence and trends of orofacial clefts in Alberta (Canada) over a 33-year period (1980 through 2011) and to determine whether the trends differ for subcategories of orofacial clefts for the period from 1997 through 2011. Design A prevalence study based on the Alberta Congenital Anomalies Surveillance System, which has multiple sources of ascertainment, capability of verification, and an upper age limit of 1 year. Inclusion All live born and stillborn babies and fetal deaths less than 20 weeks' gestation (including terminations of pregnancy) born in Alberta of mothers who reside in Alberta. Results and Conclusions Rates for cleft lip with or without cleft palate and cleft palate only have been very stable over the 33-year period (1980 through 2011). These rates include all clefts (isolated, syndromes, recognizable conditions, chromosomal and multiple congenital anomalies). Ascertainment of fetal deaths less than 20 weeks' gestation began in 1997. There are trends for the 1997 through 2011 cohort with a marginally significant increase for cleft lip with or without cleft palate in the isolated category and a significant decrease for cleft palate, mainly in the associated groups. The impact of folic acid fortification and/or multivitamins/folic acid supplementation reports in the literature have shown no consensus with respect to a change in the prevalence of orofacial clefts. It is unclear whether folic acid fortification has had any impact in Alberta.

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