scholarly journals The Role of Paternal Age and Occurrence of Orofacial Clefts in South Indian Population

2021 ◽  
Vol 10 (31) ◽  
pp. 2465-2469
Author(s):  
Soumi Samuel ◽  
Rajendra Prasad B. ◽  
Thara Chandran ◽  
Deeyah Miriam Deepak ◽  
Shaji Thomas ◽  
...  
Keyword(s):  
Congenital Anomalies ◽  
Vital Role ◽  
Paternal Age ◽  
Control Group ◽  
South Indian Population ◽  
Age Group ◽  
Orofacial Cleft ◽  
Orofacial Clefts ◽  
South Indian

BACKGROUND The association between orofacial cleft and parental age is evident. This study focuses on paternal age playing a vital role in the birth of children with orofacial clefts. We wanted to assess the role of paternal age as a factor in the development of congenital anomalies in this study. METHODS A case control study was performed on 1000 cases and 250 controls in Mangalore. The parents were interviewed regarding their age at the time of conception. RESULTS 46.4 % of fathers of the cleft children belonged to 30 - 34 years of age group and 25 % belonged to 25 - 29 years of age group at the time of conception. In the control group, 38 % belonged to 30 - 34 years of age group and 24.8 % belonged to 25 - 29 years of age group. CONCLUSIONS Paternal age in the age group of 30 - 34 years has significant contribution in the birth of orofacial children with cleft deformities. KEY WORDS Orofacial cleft, Paternal Age, Congenital anomalies

scholarly journals Age-specific cut-off levels of anti-Müllerian hormone can be used as diagnostic markers for polycystic ovary syndrome

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Fahimeh Ramezani Tehrani ◽  
Maryam Rahmati ◽  
Fatemeh Mahboobifard ◽  
Faezeh Firouzi ◽  
Nazanin Hashemi ◽  
...  
Keyword(s):  
Bayesian Method ◽  
Polycystic Ovary ◽  
Characteristic Curve ◽  
Generalized Additive Models ◽  
Additive Models ◽  
Control Group ◽  
Age Group ◽  
Predictive Values ◽  
Pcos Group

Abstract Background The majority of available studies on the AMH thresholds were not age-specific and performed the receiver operating characteristic curve (ROC) analysis, based on variations in sensitivity and specificity rather than positive and negative predictive values (PPV and NPV, respectively), which are more clinically applicable. Moreover, all of these studies used a pre-specified age categorization to report the age-specific cut-off values of AMH. Methods A total of 803 women, including 303 PCOS patients and 500 eumenorrheic non-hirsute control women, were enrolled in the present study. The PCOS group included PCOS women, aged 20–40 years, who were referred to the Reproductive Endocrinology Research Center, Tehran, Iran. The Rotterdam consensus criteria were used for diagnosis of PCOS. The control group was selected among women, aged 20–40 years, who participated in Tehran Lipid and Glucose cohort Study (TLGS). Generalized additive models (GAMs) were used to identify the optimal cut-off points for various age categories. The cut-off levels of AMH in different age categories were estimated, using the Bayesian method. Main results and the role of chance Two optimal cut-off levels of AMH (ng/ml) were identified at the age of 27 and 35 years, based on GAMs. The cut-off levels for the prediction of PCOS in the age categories of 20–27, 27–35, and 35–40 years were 5.7 (95 % CI: 5.48–6.19), 4.55 (95 % CI: 4.52–4.64), and 3.72 (95 % CI: 3.55–3.80), respectively. Based on the Bayesian method, the PPV and NPV of these cut-off levels were as follows: PPV = 0.98 (95 % CI: 0.96–0.99) and NPV = 0.40 (95 % CI: 0.30–0.51) for the age group of 20–27 years; PPV = 0.96 (95 % CI: 0.91–0.99) and NPV = 0.82 (95 % CI: 0.78–0.86) for the age group of 27–35 years; and PPV = 0.86 (95 % CI: 0.80–0.94) and NPV = 0.96 (95 % CI: 0.93–0.98) for the age group of 35–40 years. Conclusions Application of age-specific cut-off levels of AMH, according to the GAMs and Bayesian method, could elegantly assess the value of AMH in discriminating PCOS patients in all age categories.

scholarly journals Occurrence of most common shade for crown fabrication in anteriors and posteriors in south Indian population - A retrospective study

2020 ◽  
Vol 11 (SPL4) ◽  
pp. 403-409
Author(s):  
Shree Ranjan Pandey ◽  
Subash Sharma ◽  
Sowmya K
Keyword(s):  
Retrospective Study ◽  
Indian Population ◽  
South Indian Population ◽  
Age Group ◽  
The South ◽  
Microsoft Excel ◽  
Chi Square ◽  
South Indian ◽  
Males And Females ◽  
Shade Selection

Shade selection is a very important part of the treatment as it dictates the final outcomes of treatment and patient satisfaction. The most prevalent shade used in dentistry is A2/B2 shade for crown fabrication. This study was conducted on the south Indian population of the Saveetha dental college university where out of 617 patients were analysed so that the shade choices used in crown fabrication is assessed. This university based study involved the collection of data from the database from which cases of crown fabrication shade were selected and cross verified. All the data was compiled and tabulated in Microsoft Excel and exported to IBM SPSS 20. Data was represented through frequency distribution tables and Chi square tests. The highest frequency of shade used for crown fabrication amongst the South Indian population was A2 in males and females, the second most commonly used shade was A1 in females and A3 in males. Within the limitation of this study, it was found that the most common shade for crown fabrication used in the south Indian population was A2 shade, followed by A3 shade in males and A1 shade in females. The least commonly used shade was A4. The maximum cases which had a requirement of crown fabrication with esthetically pleasing shade were under the age group of 21 - 30 yrs.

scholarly journals Association between ALDH2 Variant and Alcohol Dependence in South Indian Population.

2021 ◽  
Author(s):  
A Umamageswari ◽  
C Adithan ◽  
Aarthi Manoharan ◽  
Iyanar Kannan
Keyword(s):  
Logistic Regression ◽  
Regression Analysis ◽  
Environmental Factors ◽  
Alcohol Dependence ◽  
Logistic Regression Analysis ◽  
Multiple Logistic Regression Analysis ◽  
Multivariate Logistic Regression Analysis ◽  
Control Group ◽  
South Indian Population ◽  
South Indian

Abstract Background: Alcohol dependence (AD) poses a serious medical problem and significant public health issue contributing to morbidity and mortality throughout the world. The aim of the study is to test the association of rs698 (ADH1C) and rs671(ALDH2) with the risk of alcohol dependence and to further assess the influence of environmental factors on altering the genetic susceptibility to alcoholism in south Indian Tamilian population.Methods& Results: A total of 150 alcohol dependent cases aged between 18- and 65-years fulfilling DSM-V criteria were recruited from de addiction center. Subjects in control group (n=150) had history of alcohol intake with AUDIT score less than 8. The alleles were genotyped using TaqMan SNP genotyping assays by quantitative PCR. Association with alcohol dependence was evaluated with various genetic models using chi-square test. Multiple logistic regression analysis was performed to explore the effect of covariates. The dominant (OR=0.5811,95% CI: 0.372-0.9224, p<0.01) and allelic genetic model (OR=0.6228,95% CI: 0.4328-0.9009, p<0.01) of ALDH2, rs671 between cases and controls showed a significant association of the genetic variant with AD. Multivariate logistic regression analysis revealed education level, family history, marital status were significantly associated with AD but there was no association between rs671 genotypes in the presence of these co-variates.Conclusions: Genetic factors play an important role in alcohol dependence. Combined analysis of functional genetic variants and environmental factors is warranted in future studies.

Do Orofacial Clefts Impair Breastfeeding and Increase the Prevalence of Anemia?

2021 ◽  
pp. 105566562110543
Author(s):  
Aluísio Eustáquio de Freitas Miranda-Filho ◽  
Heloisa de Sousa Gomes ◽  
Roberta Bessa Veloso Silva ◽  
Nelson Pereira Marques ◽  
Hercílio Martelli ◽  
...  
Keyword(s):  
Statistical Analysis ◽  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
The Other ◽  
Deficiency Anemia ◽  
Control Group ◽  
Orofacial Cleft ◽  
Orofacial Clefts ◽  
History Of ◽  
Prevalence Of Anemia

Objective This study aimed to correlate the prevalence of iron deficiency anemia and breastfeeding with orofacial clefts in children. Design Data on the participant profile, presence and type of the cleft lip and/or palate (CL/P), and records on anemia and breastfeeding were collected from patients’ charts, and submitted to statistical analysis by χ2 test ( p < .05; software SPSS 23.0). Results Two-hundred and ten files were divided according to: CL/P presence (cleft group;    n = 132) or absence (control group;    n = 78). Group CL/P was subdivided according to the type of cleft: CL/P-I (cleft lip;    n = 35); CL/P-II (cleft lip and palate;    n = 45); CL/P-III (cleft palate;    n = 43); and CL/P-IV (rare orofacial clefts;    n = 9). Group CL/P had significantly more records on anemia ( p = .016) and fewer records on breastfeeding (P<.01) than controls. More records on anemia occurred in CL/P-II ( p = .004) and CL/P-IV ( p = .006) than the control group. The comparison among the orofacial cleft types regarding the anemia records showed no statistically significant differences ( p = .123). Group CL/P-I had more records on breastfeeding than the other cleft types ( p < .01). Conclusions Thus, it is suggested that the breastfeeding process is more complex, and the history of anemia is more frequent, in children with cleft lip and palate or rare orofacial clefts than in children without clefts.

Design Fixation and Its Mitigation: A Study on the Role of Expertise

2013 ◽  
Vol 135 (5) ◽  
Author(s):  
Vimal K. Viswanathan ◽  
Julie S. Linsey
Keyword(s):  
Engineering Design ◽  
Design Problem ◽  
Solution Space ◽  
Idea Generation ◽  
Vital Role ◽  
Control Group ◽  
Design Fixation ◽  
Novice Designers ◽  
Novel Products

Engineering idea generation plays a vital role in the development of novel products. Prior studies have shown that designers fixate to the features of example solutions and replicate these features in their ideas. This type of fixation acts as a major hindrance in idea generation, as it restricts the solution space where designers search for their ideas. Building upon the study by Linsey et al. [2010, “A Study of Design Fixation, Its Mitigation and Perception in Engineering Design Faculty,” ASME Trans. J. Mech. Des., 132, 041003], this study hypothesizes that designers fixate to example features and this fixation can be mitigated using certain defixation materials including alternate representations of the design problem. To investigate this, the experiment conducted by Linsey et al. [2010] with engineering design faculty is replicated with novice designers. Participants generate ideas for a design problem in three groups: one group working with a fixating example, a second group working with the same example along with alternate representations of the design problem and a control group. The obtained results show that both the novice designers and design faculty fixate to the same extent, whereas the defixation materials have differential effect on the two groups. This result indicates that design researchers need to be very careful in developing methods and guidelines that are formulated and tested with studies on novice designers. The effectiveness of such measures may vary with the level of expertise of the designer.

scholarly journals Role of cytohormonal study in normal pregnancy and in threatened abortion

2018 ◽  
Vol 7 (5) ◽  
pp. 1735
Author(s):  
Shailesh B. Patil ◽  
Milind B. Patil
Keyword(s):  
Normal Pregnancy ◽  
Fetal Outcome ◽  
Control Group ◽  
Vaginal Smear ◽  
Age Group ◽  
Number Of Patients ◽  
Significant Difference ◽  
Parity Number ◽  
Threatened Abortion

Background: It is certain from clinical experience of many that one or more hemorrhages in early pregnancy can still end up in good fetal outcome. So, our study deals with comparison of cytohormonal study in pregnancy and threatened abortion. The study was conducted with the aim of utilizing colpocytogram as a tool in assessing and treating cases of threatened abortion and comparing them with normal pregnant women.Methods: Patients attending antenatal care unit on outdoor basis and labelled as normal pregnancy cases were considered as control group. The patients of threatened abortion were studied when they were admitted in Gynecology department for indoor treatment. Patients were studied taking into consideration their age, parity, number of abortions, complaints (P/V bleeding, pain in abdomen), gestational age, per abdomen and per vaginal findings and also USG findings and vaginal smear pattern.Results: Maximum number of patients was present in the age group of 21-25 years in both the groups. While only 13.33% had normal smear pattern in threatened abortion group. 86.67% patients in threatened abortion group showed abnormal smear pattern. There is statistically significant difference was found (p<0.05). There is statistically significant was found (P<0.01) and indicates good effects of the drug on the vaginal epithelium.Conclusions: The cytohormonal study acts as a simple, reliable, good, noninvasive method for evaluation of hormonal pattern in normal pregnancy and threatened abortion. 

A Study on the Role of Expertise in Design Fixation and its Mitigation

2012 ◽  
Author(s):  
Vimal Viswanathan ◽  
Julie Linsey
Keyword(s):  
Design Problem ◽  
Solution Space ◽  
Idea Generation ◽  
Vital Role ◽  
Control Group ◽  
Design Fixation ◽  
Novice Designers ◽  
Novel Products

Engineering idea generation plays a vital role in the development of novel products. Prior studies have shown that designers fixate to the features of example solutions and replicate these features in their ideas. This is a major hindrance in idea generation as it restricts the solution space where designers search for their ideas. This study hypothesizes that though expert designers fixate to example features, they still can outperform novices in terms of quantity of ideas as they have a larger set of knowledge acquired through their experience. To investigate this, the experimental by Linsey et al. is replicated for novice designers. Novices generate ideas for a design problem in three groups: one group working with a fixating example, a second group working with the same example along with alternate representations for the design problem and a control group only presented with the problem and no additional materials. The obtained results support the hypothesis. Both novice and expert designers are fixated to the example features, but the expert designers generated more nonredundant ideas. The alternate representations of the design problem help experts in mitigating their fixation, whereas in novices, these have no effect.

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