Epidemiology of orofacial clefts in a Danish county over 35 years – Before and after implementation of a prenatal screening programme for congenital anomalies

2018 ◽  
Vol 61 (9) ◽  
pp. 489-492 ◽  
Author(s):  
Eva Berenth Paaske ◽  
Ester Garne
Keyword(s):  
Congenital Anomalies ◽  
Prenatal Screening ◽  
Screening Programme ◽  
Orofacial Clefts ◽  
Before And After

scholarly journals 819 Orofacial Clefts and Associated Congenital Anomalies: The 18 Years Experience of a Multidisciplinary Group in a Tertiary Hospital in Portugal

2010 ◽  
Vol 68 ◽  
pp. 412-412
Author(s):  
L Correia-Costa ◽  
J Miranda ◽  
V Mendonça ◽  
R Furfuro ◽  
A Bessa-Monteiro ◽  
...  
Keyword(s):  
Congenital Anomalies ◽  
Tertiary Hospital ◽  
Orofacial Clefts ◽  
Multidisciplinary Group

scholarly journals Data Quality Assessment on Congenital Anomalies in Ontario, Canada

2020 ◽  
Vol 8 ◽  
Author(s):  
Qun Miao ◽  
Aideen M. Moore ◽  
Shelley D. Dougan
Keyword(s):  
Data Quality ◽  
Congenital Anomalies ◽  
Kappa Statistics ◽  
Discharge Abstract Database ◽  
Ontario Health Insurance Plan ◽  
Orofacial Clefts ◽  
Great Vessels ◽  
Icd 10 ◽  
Future Data ◽  
Birth Records

Background: Congenital anomalies (CAs) are a major cause of infant morbidity and mortality in Canada. Reliably identifying CAs is essential for CA surveillance and research. The main objective of this study was to assess the agreement of eight sentinel anomalies including: neural tube defects (NTD), orofacial clefts, limb deficiency defects (LDD), Down syndrome (DS), tetralogy of Fallot (TOF), gastroschisis (GS), hypoplastic left heart syndrome (HLHS) and transposition of great vessels (TGA) captured in the BORN Information System (BIS) database and the Canadian Institute for Health Information (CIHI) Discharge Abstract Database (DAD).Methods: Live birth and stillbirth records between the BIS and CIHI-DAD in the fiscal years of 2012–2013 to 2015–2016 were linked using 10 digit infant Ontario Health Insurance Plan (OHIP) numbers. Percent agreement and Kappa statistics were performed to assess the reliability (agreement) of CAs identified in the linked BIS and CIHI-DAD birth records. Then, further investigations were conducted on those CA cases identified in the CIHI-DAD only.Results: Kappa coefficients of the eight selected CAs between BIS (“Confirmed” or “Suspected” cases) and CIHI-DAD were 0.96 (95% CI: 0.93–0.98) for GS; 0.81 (95% CI: 0.78–0.83) for Orofacial clefts; 0.75 (95% CI: 0.72–0.77) for DS; 0.71 (95% CI: 0.65–0.77) for TOF; 0.62 (95% CI: 0.55–0.68) for TGA; 0.59 (95% CI: 0.49–0.68) for HLHS, 0.53 (95% CI: 0.46–0.60) for NTD-all; and 0.30 (95% CI: 0.23–0.37) for LDD.Conclusions: The degree of agreement varied among sentinel CAs identified between the BIS and CIHI. The potential reasons for discrepancies include incompleteness of capturing CAs using existing picklist values, especially for certain sub-types, incomplete neonatal special care data in the BIS, and differences between clinical diagnosis in the BIS and ICD-10-CA classification in the DAD. A future data abstraction study will be conducted to investigate the potential reasons for discrepancies of CA capture between two databases. This project helps quantify the quality of CA data collection in the BIS, enhances understanding of CA prevalence in Ontario and provides direction for future data quality improvement activities.

scholarly journals Superfund Cleanups and Infant Health

2011 ◽  
Vol 101 (3) ◽  
pp. 435-441 ◽  
Author(s):  
Janet Currie ◽  
Michael Greenstone ◽  
Enrico Moretti
Keyword(s):  
Birth Outcomes ◽  
Congenital Anomalies ◽  
Infant Health ◽  
Superfund Site ◽  
Difference In Differences ◽  
Before And After ◽  
A Site

We are the first to examine the effect of Superfund cleanups on infant health rather than focusing on proximity to a site. We study singleton births to mothers residing within 5km of a Superfund site between 1989–2003 in five large states. Our “difference in differences” approach compares birth outcomes before and after a site clean-up for mothers who live within 2,000 meters of the site and those who live between 2,000–5,000 meters of a site. We find that proximity to a Superfund site before cleanup is associated with a 20 to 25% increase in the risk of congenital anomalies.

scholarly journals Incidence of Orofacial Clefts in Kumasi, Ghana

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
P. Agbenorku ◽  
M. Yore ◽  
K. A. Danso ◽  
C. Turpin
Keyword(s):  
Cleft Palate ◽  
Congenital Anomalies ◽  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Orofacial Clefts ◽  
Female Ratio ◽  
Live Births ◽  
Male Female Ratio ◽  
Cleft Lip Palate ◽  
History Of

Background. Cleft lip and cleft palate are among the most common orofacial congenital anomalies. This study is to establish Orofacial Clefts Database for Kumasi, Ghana, with a view to extend it to other cities in future to obtain a national orofacial anomaly database. Methods. A descriptive prospective survey was carried out at eleven selected health facilities in Kumasi. Results. The total number of live births recorded was 27,449. Orofacial anomalies recorded were 36, giving an incidence of 1.31/1000 live births or 1 in 763 live births. The mean maternal age of cleft lip/palate babies was 29.85 years (range 18–40 years). The male : female ratio for the orofacial anomalies babies was 1.3 : 1; the male : female ratio was 0.5 : 1 in the cleft lip group, 1.3 : 1 in the cleft lip and palate group, and 4 : 1 in the cleft palate group. The majority of clefts were unilateral (69.4%, n=25), with females (n=14) outnumbering males (n=11). A family history of cleft was recorded with five babies (13.9%). Associated congenital anomalies were recorded in seven (19.4%) cleft lips and/or palates. Conclusion. The incidence of 1 in 763 live births found in this study indicates that cleft lip/palate is a common congenital anomaly in Kumasi.

scholarly journals The Role of Paternal Age and Occurrence of Orofacial Clefts in South Indian Population

2021 ◽  
Vol 10 (31) ◽  
pp. 2465-2469
Author(s):  
Soumi Samuel ◽  
Rajendra Prasad B. ◽  
Thara Chandran ◽  
Deeyah Miriam Deepak ◽  
Shaji Thomas ◽  
...  
Keyword(s):  
Congenital Anomalies ◽  
Vital Role ◽  
Paternal Age ◽  
Control Group ◽  
South Indian Population ◽  
Age Group ◽  
Orofacial Cleft ◽  
Orofacial Clefts ◽  
South Indian

BACKGROUND The association between orofacial cleft and parental age is evident. This study focuses on paternal age playing a vital role in the birth of children with orofacial clefts. We wanted to assess the role of paternal age as a factor in the development of congenital anomalies in this study. METHODS A case control study was performed on 1000 cases and 250 controls in Mangalore. The parents were interviewed regarding their age at the time of conception. RESULTS 46.4 % of fathers of the cleft children belonged to 30 - 34 years of age group and 25 % belonged to 25 - 29 years of age group at the time of conception. In the control group, 38 % belonged to 30 - 34 years of age group and 24.8 % belonged to 25 - 29 years of age group. CONCLUSIONS Paternal age in the age group of 30 - 34 years has significant contribution in the birth of orofacial children with cleft deformities. KEY WORDS Orofacial cleft, Paternal Age, Congenital anomalies

PRODUCTION OF CONGENITAL ANOMALIES IN MAMMALS BY MATERNAL DIETARY DEFICIENCIES

PEDIATRICS ◽  
1957 ◽  
Vol 19 (4) ◽  
pp. 764-776
Author(s):  
Marjorie M. Nelson
Keyword(s):  
Congenital Anomalies ◽  
Critical Period ◽  
Genetic Factors ◽  
Marked Contrast ◽  
Teratogenic Effects ◽  
Vitamin Deficiencies ◽  
Before And After ◽  
Systems Studies ◽  
In Pregnancy ◽  
Dietary Deficiency

Multiple or single congenital anomalies may be produced experimentally by certain maternal dietary deficiencies. The similarity of the anomalies resulting from all acute dietary deficiencies and other acute teratogenic procedures is striking. When the dietary deficiency is controlled by the use of anti-metabolites, it can easily be demonstrated that the teratogenic effects vary with the time of instituting the deficiency and with its duration or severity. It can also be demonstrated that the period of sensitivity to the teratogenic dietary deficiencies is usually limited to the critical period of differentiation and organogenesis, as it is in irradiation. However, fetal vitamin deficiencies similar to those observed in the adult can probably be produced by the deficiency later in pregnancy. The severe fetal damage is in marked contrast to the relatively slight effects on the maternal organism. Presumably, although this point has not been proven, the effect of the deficiency is directly on the fetus and indicates that certain vitamins play a highly significant role in embryonic differentiation and organogenesis. We already have considerable knowledge concerning the biochemical reactions with which the B vitamins are concerned in adult tissues. It is possible that, by use of these specific vitamin deficiencies as tools, we may succeed in identifying certain key reactions in embryonic differentiation and organogenesis and thus advance our knowledge of chemical embryology. The teratogenic dietary deficiencies can provide abundant material for the pathologist to study the early stages of specific anomalies. For the physiologist, studies of anomalous conditions before and after birth are possible for some organs and systems. Studies of the interrelations of nutritional and genetic factors should lead to increasing knowledge concerning individual susceptibility to such teratogenic conditions and the application of these findings to man. The briefness of the period necessary to affect fetal development and the irreversibility of fetal damage by dietary supplementation later in pregnancy must be emphasized.

Sign in / Sign up

Export Citation Format

Share Document