Self-Efficacy as a Target Population Segmentation Strategy in a Diet and Cancer Risk Reduction Campaign

Prophylactic mastectomy is an aggressive strategy for breast cancer risk reduction. The indications and efficiency of this procedures are not yet clearly defined. Randomized, prospective studies, comparing different surgical procedures with other modalities of breast cancer risk reduction are lacking. The report evaluates the existing controversy, based on Medline search in the following sequence: risk factors, possibilities of risk reduction, effectiveness of risk reduction, technical considerations and recommendations. Patient selection is difficult and needs an interdisciplinary approach. The women have to be well informed about all treatment alternatives and various reconstructive procedures. An appropriate risk reduction strategy should be selected individually for each patient. Up to now, there exist only recommendations from different institutions but no definitive guidelines.

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Faculty Opinions recommendation of Use of endocrine therapy for breast cancer risk reduction: ASCO clinical practice guideline update.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.736545182.793567952 ◽

2019 ◽

Author(s):

Eva Chalas

Keyword(s):

Breast Cancer ◽

Clinical Practice ◽

Breast Cancer Risk ◽

Cancer Risk ◽

Risk Reduction ◽

Endocrine Therapy ◽

Clinical Practice Guideline ◽

Practice Guideline ◽

Breast Cancer Risk Reduction ◽

Cancer Risk Reduction

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Metabolic Surgery and Cancer Risk: An Opportunity for Mechanistic Research

Cancers ◽

10.3390/cancers13133183 ◽

2021 ◽

Vol 13 (13) ◽

pp. 3183

Author(s):

Edward R. Sauter ◽

Brandy Heckman-Stoddard

Keyword(s):

Weight Loss ◽

Cancer Risk ◽

Risk Reduction ◽

Dramatic Improvement ◽

Role Of Government ◽

Sustained Weight Loss ◽

Historical Role ◽

Cancer Risk Reduction

Metabolic (bariatric) surgery (MBS) is recommended for individuals with a BMI > 40 kg/m2 or those with a BMI 35–40 kg/m2 who have one or more obesity related comorbidities. MBS leads to greater initial and sustained weight loss than nonsurgical weight loss approaches. MBS provides dramatic improvement in metabolic function, associated with a reduction in type 2 diabetes mellitus and cardiovascular risk. While the number of MBS procedures performed in the U.S. and worldwide continues to increase, they are still only performed on one percent of the affected population. MBS also appears to reduce the risk of certain obesity related cancers, although which cancers are favorably impacted vary by study, who benefits most is uncertain, and the mechanism(s) driving this risk reduction are mostly speculative. The goal of this manuscript is to highlight 1) emerging evidence that MBS influences cancer risk, and that the potential benefit appears to vary based on cancer, gender, surgical procedure, and likely other variables; 2) the role of the NIH in MBS research in T2DM and CV risk for many years, and more recently in cancer; and 3) the opportunity for research to understand the mechanism(s) by which MBS influences cancer. There is evidence that women benefit more from MBS than men, that MBS may actually increase the risk of colorectal cancer in both women and men, and there is speculation that the benefit in cancer risk reduction may vary according to which MBS procedure an individual undergoes. Herein, we review what is currently known, the historical role of government, especially the National Institutes of Health (NIH), in driving this research, and provide suggestions that we believe could lead to a better understanding of whether and how MBS impacts cancer risk, which cancers are impacted either favorably or unfavorably, the role of the NIH and other research agencies, and key questions to address that will help us to move the science forward.

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