Model-Based Decision Making in Early Clinical Development: Minimizing the Impact of a Blood Pressure Adverse Event

Objective: Emotional states are expressed in body and mind through subjective experience of physiological changes. In previous work, subliminal priming of anger prior to lexical decisions increased systolic blood pressure (SBP). This increase predicted the slowing of response times (RT), suggesting that baroreflex-related autonomic changes and their interoceptive (feedback) representations, influence cognition. Alexithymia is a subclinical affective dysfunction characterized by difficulty in identifying emotions. Atypical autonomic and interoceptive profiles are observed in alexithymia. Therefore, we sought to identify mechanisms through which SBP fluctuations during emotional processing might influence decision-making, including whether alexithymia contributes to this relationship. Methods Thirty-two male participants performed an affect priming paradigm and completed the Toronto Alexithymia Scale. Emotional faces were briefly presented (20ms) prior a short-term memory task. RT, accuracy and SBP were recorded on a trial-by-trial basis. Generalized mixed-effects linear models were used to evaluate the impact of emotion, physiological changes, alexithymia score, and their interactions, on performances. Results A main effect of emotion was observed on accuracy. Participants were more accurate on trials with anger primes, compared to neutral priming. Greater accuracy was related to increased SBP. An interaction between SBP and emotion was observed on RT: Increased SBP was associated with RT prolongation in the anger priming condition, yet this relationship was absent under the sadness priming. Alexithymia did not significantly moderate the above relationships. Conclusions Our data suggest that peripheral autonomic responses during affective challenges guide cognitive processes. We discuss our findings in the theoretical framework proposed by Lacey and Lacey (1970).

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Grey target decision-making model of interval grey number based on cone volume

Grey Systems Theory and Application ◽

10.1108/gs-04-2017-0010 ◽

2017 ◽

Vol 7 (2) ◽

pp. 247-258 ◽

Cited By ~ 3

Author(s):

Lizhen Wang ◽

Wuyong Qian

Keyword(s):

Decision Making ◽

Entropy Method ◽

Maximal Entropy ◽

Information Distortion ◽

Content Type ◽

Model Based ◽

Proposed Model ◽

Grey Number ◽

Decision Making Model ◽

The Impact

Purpose The purpose of this paper is to propose a grey target decision model based on cobweb area in order to overcome the effect and influence from the extreme value of the index on the decision result. However, it does not take into account the impact of the correlation between indicators on the angle of the index, and produce a certain degree decision information distortion as a result of the equal angle between the indicators. In order to solve the above problems, a novel grey decision-making model based on cone volume is proposed. Design/methodology/approach In this paper, the model uses the whitening weight function to whiten the interval grey number, and the Delphi method and the maximal entropy method are exploited to integrate the weight of the index. On the basis of this, the center of the bull’s eye, the weight and the index value are constructed as the center circle, the radius, and the high cone, respectively. The scheme is selected by the volume of the cone, the decision is made according to the order relation, and the example is utilized to prove and analyze the validity of the proposed model. Findings The results show that the proposed model can well improve the traditional grey target decision-making model from the modeling object and modeling method. Practical implications The method exposed in the paper can be used to deal with the grey target decision-making problems which characteristics are multi-indexes, and the attribute values are interval grey numbers. Originality/value The paper succeeds in overcoming the disadvantages of grey target decision making based on the target center distance and the cobweb area.

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The impact of government subsidies on private pension enterprises: a decision-making model based on their CSR levels

IEEE Access ◽

10.1109/access.2021.3136594 ◽

2021 ◽

pp. 1-1

Author(s):

Tingting Jiang ◽

Zheng He ◽

Guangming Xiang ◽

Taotao Hu

Keyword(s):

Decision Making ◽

Private Pension ◽

Government Subsidies ◽

Model Based ◽

Decision Making Model ◽

The Impact

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Model‐Based Meta‐Analysis Compares DAS28 Rheumatoid Arthritis Treatment Effects and Suggests an Expedited Trial Design for Early Clinical Development

Clinical Pharmacology & Therapeutics ◽

10.1002/cpt.2023 ◽

2020 ◽

Author(s):

Tarek A. Leil ◽

Yasong Lu ◽

Marion Bouillon‐Pichault ◽

Robert Wong ◽

Miroslawa Nowak

Keyword(s):

Rheumatoid Arthritis ◽

Trial Design ◽

Treatment Effects ◽

Meta Analysis ◽

Clinical Development ◽

Rheumatoid Arthritis Treatment ◽

Model Based ◽

Early Clinical Development

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Quota Women Are Threatening to Men

Swiss Journal of Psychology ◽

10.1024/1421-0185/a000195 ◽

2017 ◽

Vol 76 (3) ◽

pp. 107-116 ◽

Cited By ~ 4

Author(s):

Klea Faniko ◽

Till Burckhardt ◽

Oriane Sarrasin ◽

Fabio Lorenzi-Cioldi ◽

Siri Øyslebø Sørensen ◽

...

Keyword(s):

Decision Making ◽

Organizational Performance ◽

Gender Stereotypes ◽

Perceived Threat ◽

Preferential Treatment ◽

Public Sector Employees ◽

Different Types ◽

Low Levels ◽

Women In Decision Making ◽

The Impact

Abstract. Two studies carried out among Albanian public-sector employees examined the impact of different types of affirmative action policies (AAPs) on (counter)stereotypical perceptions of women in decision-making positions. Study 1 (N = 178) revealed that participants – especially women – perceived women in decision-making positions as more masculine (i.e., agentic) than feminine (i.e., communal). Study 2 (N = 239) showed that different types of AA had different effects on the attribution of gender stereotypes to AAP beneficiaries: Women benefiting from a quota policy were perceived as being more communal than agentic, while those benefiting from weak preferential treatment were perceived as being more agentic than communal. Furthermore, we examined how the belief that AAPs threaten men’s access to decision-making positions influenced the attribution of these traits to AAP beneficiaries. The results showed that men who reported high levels of perceived threat, as compared to men who reported low levels of perceived threat, attributed more communal than agentic traits to the beneficiaries of quotas. These findings suggest that AAPs may have created a backlash against its beneficiaries by emphasizing gender-stereotypical or counterstereotypical traits. Thus, the framing of AAPs, for instance, as a matter of enhancing organizational performance, in the process of policy making and implementation, may be a crucial tool to countering potential backlash.

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