scholarly journals Glyceryl Monooleate/Poloxamer 407 Cubic Nanoparticles as Oral Drug Delivery Systems: I. In Vitro Evaluation and Enhanced Oral Bioavailability of the Poorly Water-Soluble Drug Simvastatin

2009 ◽  
Vol 10 (3) ◽  
Author(s):  
Jie Lai ◽  
Jianming Chen ◽  
Yi Lu ◽  
Jing Sun ◽  
Fuqiang Hu ◽  
...  
Keyword(s):  
Oral Drug Delivery ◽  
Water Soluble ◽  
Poloxamer 407 ◽  
Oral Drug ◽  
Glyceryl Monooleate ◽  
Water Soluble Drug ◽  
Poorly Water Soluble ◽  
Oral Drug Delivery Systems ◽  
Poorly Water Soluble Drug

Formulation and Evaluation of Orodispersible Tablet of poorly water Soluble Drug ‘Fenofibrate’ by Using Solubility Enhancement Technique

2021 ◽  
pp. 279-283
Author(s):  
Ali Asgar Dabeer ◽  
Dinesh Kumar Mishra ◽  
Nadeem Farooqui ◽  
Arpit Gawshinde
Keyword(s):  
Oral Drug Delivery ◽  
Release Kinetics ◽  
Water Soluble ◽  
Oral Drug ◽  
Oral Formulations ◽  
Water Soluble Drug ◽  
Weight Variation ◽  
Physicochemical Evaluation ◽  
Poorly Water Soluble ◽  
Poorly Water Soluble Drug

In the recent years scientific and technological advancements have been made in the research and development of oral drug delivery systems. The aim of this study was to formulate and evaluate of orodispersible tablets by direct compression for fenofibrate by using super fast disintegrating agents like croscarmellose sodium. The use of super disintegrant and excipient for preparation of fast disintegrating is highly effective and commercially feasible. In the present investigation poorly water soluble drug is one of the most important parameters of oral formulations sucessfully developed fenofibrate was using solvent evaporation method drug: PEG 6000 in (1:5 w/w). The formulation F7 was the optimized formula that showed satisfactory results with various physicochemical evaluation parameters like thickness, hardness, weight variation, friability, drug content, % drug release almost 79.98% within 15 min. and it was follow the maximum higuchi release kinetics that regression coefficient values ‘r2’= 0.995.

scholarly journals 3D Printing of Dapagliflozin Containing Self-Nanoemulsifying Tablets: Formulation Design and In Vitro Characterization

Pharmaceutics ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 993
Author(s):  
Mohammed S. Algahtani ◽  
Abdul Aleem Mohammed ◽  
Javed Ahmad ◽  
M. M. Abdullah ◽  
Ehab Saleh
Keyword(s):  
3D Printing ◽  
Solid Phase ◽  
Immediate Release ◽  
Water Soluble ◽  
Solid Matrix ◽  
Water Soluble Drug ◽  
Poorly Water Soluble ◽  
3D Printing Technique ◽  
Poorly Water Soluble Drug

The 3D printing techniques have been explored extensively in recent years for pharmaceutical manufacturing and drug delivery applications. The current investigation aims to explore 3D printing for the design and development of a nanomedicine-based oral solid dosage form of a poorly water-soluble drug. A self-nanoemulsifying tablet formulation of dapagliflozin propanediol monohydrate was developed utilizing the semisolid pressure-assisted microsyringe (PAM) extrusion-based 3D printing technique. The developed formulation system consists of two major components (liquid and solid phase), which include oils (caproyl 90, octanoic acid) and co-surfactant (PEG 400) as liquid phase while surfactant (poloxamer 188) and solid matrix (PEG 6000) as solid-phase excipients that ultimately self-nanoemulsify as a drug encapsulated nanoemulsion system on contact with aqueous phase/gastrointestinal fluid. The droplet size distribution of the generated nanoemulsion from a self-nanoemulsifying 3D printed tablet was observed to be 104.7 ± 3.36 nm with polydispersity index 0.063 ± 0.024. The FT-IR analysis of the printed tablet revealed that no drug-excipients interactions were observed. The DSC and X-RD analysis of the printed tablet revealed that the loaded drug is molecularly dispersed in the crystal lattice of the tablet solid matrix and remains solubilized in the liquid phase of the printed tablet. SEM image of the drug-loaded self-nanoemulsifying tablets revealed that dapagliflozin propanediol monohydrate was completely encapsulated in the solid matrix of the printed tablet, which was further confirmed by SEM-EDS analysis. The in vitro dissolution profile of dapagliflozin-loaded self-nanoemulsifying tablet revealed an immediate-release drug profile for all three sizes (8 mm, 10 mm, and 12 mm) tablets, exhibiting >75.0% drug release within 20 min. Thus, this study has emphasized the capability of the PAM-based 3D printing technique to print a self-nanoemulsifying tablet dosage form with an immediate-release drug profile for poorly water-soluble drug.

In Vitro-In Vivo Correlation for Solid Dispersion of a Poorly Water-Soluble Drug Efonidipine Hydrochloride

2020 ◽  
Vol 21 (5) ◽  
Author(s):  
Xu Cheng ◽  
Jianlong Gao ◽  
Jiaqi Li ◽  
Gang Cheng ◽  
Meijuan Zou ◽  
...  
Keyword(s):  
Solid Dispersion ◽  
Water Soluble ◽  
Water Soluble Drug ◽  
Poorly Water Soluble ◽  
Poorly Water Soluble Drug

Design, Optimization and Evaluation of Repaglinide Self-Nanoemulsifying Drug Delivery for Enhanced Solubility

2017 ◽  
Vol 10 (6) ◽  
pp. 3920-3928
Author(s):  
Mahalaxmi K ◽  
Sailu Ch
Keyword(s):  
Drug Delivery ◽  
Water Soluble ◽  
In Vitro Dissolution ◽  
Antidiabetic Drug ◽  
Water Soluble Drug ◽  
Enhanced Solubility ◽  
Poorly Water Soluble ◽  
Capmul Mcm ◽  
Poorly Water Soluble Drug

The aim of study was to develop self-nanoemulsifying systems of poorly water-soluble drug repaglinide, which is an antidiabetic drug in the class of medications known as meglitinides. Solubility of repaglinide in oily phases and surfactants was determined to identify components of self-nanoemulsifying drug delivery system (SNEDDS). Surfactants and oil was selected based on solubility studies were further screened for their efficiency in formulation. Acrysol K 150, Kolliphor EL and Capmul MCM were selected as oil, surfactant and co-surfactant respectively. Formulation F8 was found to be optimized formulation on the basis of in vitro dissolution studies, particle size and zeta potential. The optimized formulation was then subjected to stability studies and was found to be stable after 6 months. Thus, SNEDDS were found to be influential in improving the release performance of repaglinide, indicating their potential to improve the solubility and oral bioavailability of repaglinide.  

scholarly journals In vitro evaluation of sustained released matrix tablets containing ibuprofen: a model poorly water-soluble drug

2016 ◽  
Vol 52 (4) ◽  
pp. 751-759 ◽  
Author(s):  
Wendy Leticia Guerra-Ponce ◽  
Sandra Leticia Gracia-Vásquez ◽  
Patricia González-Barranco ◽  
Ivonne Antonieta Camacho-Mora ◽  
Yolanda Araceli Gracia-Vásquez ◽  
...  
Keyword(s):  
Water Soluble ◽  
Matrix Tablets ◽  
In Vitro Evaluation ◽  
Water Soluble Drug ◽  
Poorly Water Soluble ◽  
Poorly Water Soluble Drug

scholarly journals Novel Application of Mixed Solvency Concept to Develop and Formulate Dry Powder Injection for Reconstitution of a Poorly Water Soluble Drug, Amlodipine Besylate and their Evaluations

2021 ◽  
Vol 11 (4-S) ◽  
pp. 101-108
Author(s):  
Yashi Thakur ◽  
R.K. Maheshwari
Keyword(s):  
Water Soluble ◽  
Oral Dosage ◽  
Poloxamer 407 ◽  
Powder Injection ◽  
Amlodipine Besylate ◽  
Dry Powder ◽  
Synergistic Enhancement ◽  
Water Soluble Drug ◽  
Poorly Water Soluble ◽  
Poorly Water Soluble Drug

In the recent generation of pharmaceutical research, it has been observed that many newly designed and discovered drug products have less water solubility. Thus, leading to difficulties in several developmental, manufacturing and administrative processes. Furthermore, the clinical trials of these drugs have witnessed a great failure due to their poor pharmacokinetics. The lineup of our research work was promotion of mixed solvency concept by formulating the dry powder injection for reconstitution of poorly water-soluble drug amlodipine besylate by decreasing the solubilisers concentration in small proportion for expected synergistic enhancement of drug solubility in water. Solubilisers used are sodium benzoate, sodium caprylate, PVPK-25, sodium citrate, niacinamide, poloxamer 407, sodium acetate, L-arginine, benzoic acid, β-cyclodextrin and lysine hydrochloride to developed the dry powder injection for reconstitution of amlodipine besylate. The reconstitution time of amlodipine besylate injections were found 58 sec, 36 sec and 1 min 10 sec in selected blends. This drug is slightly soluble in water, and it comes in various forms, including tablets and other oral dosage forms. However, no amlodipine besylate dry powder injection or ready-made injections are currently available in the market. Dry powder injection for reconstitution of amlodipine besylate was formulated successfully and mixed solvency concept has been successfully employed. Keywords: Mixed solvency concept, Amlodipine besylate, Dry powder injection for reconstitution, Solubilisers, Solubility.

scholarly journals FORMULATION AND EVALUATION OF MUCOADHESIVE CLOTRIMAZOLE VAGINAL TABLET USING LIQUISOLID TECHNOLOGY

2019 ◽  
Vol 9 (4-A) ◽  
pp. 477-485
Author(s):  
Dr. Monica Rao ◽  
Abhishek Zope
Keyword(s):  
Ex Vivo ◽  
Water Soluble ◽  
Vaginal Candidiasis ◽  
Drug Formulations ◽  
Effective Technique ◽  
Water Soluble Drug ◽  
Dissolution Properties ◽  
Poorly Water Soluble ◽  
Poorly Water Soluble Drug

Liquisolid technology is very effective technique for improving the solubility and dissolution properties of poorly water soluble drug formulations like Clotrimazole. Clotrimazole is a BCS Class II, antifungal drug used for treatment for Vaginal Candidiasis.  In this liquisolid technique the drug soluble in non volatile solvents and then it converted into free flowing, non adherent powder, which can be compressed into tablet. Here N-methyle-2-pyrrolidone and propylene glycol is used in the ratio of 1:1 as a solvent. Neusilin US2 and Aerosil 200 used as Coating and Carrier material respectively. For mucoadhesion on vaginal wall Sodium carboxymethyle cellulose used as a mucoadhesive agent. Mucoadhesive tablets were prepared using direct compression technique. Magnesium Stearate used as a glidant. Mucoadhesive liquisolid tablets were evaluated as precompression evalutions and post compression evaluations. Future tablets were evaluated as In vitro and Ex vivo evaluations. The optimized batch showed that In vitro release in simulated vaginal fluid pH 4.5 in 6 hr was 99%. Ex vivo diffusion studies of optimized batch showed 80% of drug diffusion in 6 hr. Mucoadhesive strength showed high mucoadhesion of optimized batch that is 36 gm. From this study it was concluded that liquisolid technology is an effective technique to improve solubility and dissolution properties of poorly water soluble drug formulations like Clotrimazole.

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