Spherical Agglomerates of Lactose Reduce Segregation in Powder Blends and Improve Uniformity of Tablet Content at High Drug Loads

2021 ◽  
Vol 23 (1) ◽  
Author(s):  
Dejan Lamešić ◽  
Blaž Grilc ◽  
Robert Roškar ◽  
Selina Kolokytha ◽  
Jürgen Hofmann ◽  
...  
Keyword(s):  
High Drug ◽  
Powder Blends ◽  
Spherical Agglomerates

scholarly journals Improved properties of fine active pharmaceutical ingredient powder blends and tablets at high drug loading via dry particle coating

2018 ◽  
Vol 543 (1-2) ◽  
pp. 288-299 ◽  
Author(s):  
Kuriakose Kunnath ◽  
Zhonghui Huang ◽  
Liang Chen ◽  
Kai Zheng ◽  
Rajesh Davé
Keyword(s):  
Drug Loading ◽  
Active Pharmaceutical Ingredient ◽  
High Drug ◽  
Particle Coating ◽  
Powder Blends ◽  
Dry Particle Coating ◽  
High Drug Loading

Investigating the influence of aromatic moieties on the formulation of hydrophobic natural products and drugs in poly(2-oxazoline) based amphiphiles

2018 ◽  
Author(s):  
Robert Luxenhofer ◽  
Michael M Lübtow ◽  
Lukas Hahn ◽  
Thomas Lorson ◽  
Rainer Schobert
Keyword(s):  
Natural Products ◽  
Small Molecules ◽  
Water Solubility ◽  
Drug Loading ◽  
High Drug ◽  
Long Term Stability ◽  
Aromatic Content ◽  
Important Interaction ◽  
Amorphous Structures ◽  
High Drug Loading

Many natural compounds with interesting biomedical properties share one physicochemical property, namely a low water solubility. Polymer micelles are, among others, a popular means to solubilize hydrophobic compounds. The specific molecular interactions between the polymers and the hydrophobic drugs are diverse and recently it has been discussed that macromolecular engineering can be used to optimize drug loaded micelles. Specifically, π-π stacking between small molecules and polymers has been discussed as an important interaction that can be employed to increase drug loading and formulation stability. Here, we test this hypothesis using four different polymer amphiphiles with varying aromatic content and various natural products that also contain different relative amounts of aromatic moieties. While in the case of paclitaxel, having the lowest relative content of aromatic moieties, the drug loading decreases with increasing relative aromatic amount in the polymer, the drug loading of curcumin, having a much higher relative aromatic content, is increased. Interestingly, the loading using schizandrin A, a dibenzo[a,c]cyclooctadiene lignan with intermediate relative aromatic content is not influenced significantly by the aromatic content of the polymers employed. The very high drug loading, long term stability, the ability to form stable highly loaded binary coformulations in different drug combinations, small sized formulations and amorphous structures in all cases, corroborate earlier reports that poly(2-oxazoline) based micelles exhibit an extraordinarily high drug loading and are promising candidates for further biomedical applications. The presented results underline that the interaction between the polymers and the incorporated small molecules are complex and must be investigated in every specific case.<br>

Design of dual-responsive nanocarries with high drug loading capacity based on hollow mesoporous organosilica nanoparticles

2019 ◽  
Vol 233 ◽  
pp. 230-235 ◽  
Author(s):  
Li-li Lu ◽  
Wen-ya Xiong ◽  
Jun-bin Ma ◽  
Tian-fang Gao ◽  
Si-yuan Peng ◽  
...  
Keyword(s):  
Drug Loading ◽  
Loading Capacity ◽  
High Drug ◽  
Dual Responsive ◽  
Mesoporous Organosilica ◽  
High Drug Loading

Cellulose nanocrystals reinforced highly stretchable thermal-sensitive hydrogel with ultra-high drug loading

2021 ◽  
Vol 266 ◽  
pp. 118122
Author(s):  
Tianxing Chen ◽  
Yuan Yang ◽  
Hui Peng ◽  
Andrew K. Whittaker ◽  
Yao Li ◽  
...  
Keyword(s):  
Cellulose Nanocrystals ◽  
Drug Loading ◽  
High Drug ◽  
Highly Stretchable ◽  
High Drug Loading

scholarly journals Unveiling the Interaction Potential Surface between Drug-Entrapped Polymeric Micelles Clarifying the High Drug Nanocarrier Efficiency

Nano Letters ◽  
2021 ◽  
Vol 21 (3) ◽  
pp. 1303-1310
Author(s):  
Takeshi Morita ◽  
Sayaka Mukaide ◽  
Ziqiao Chen ◽  
Kenjirou Higashi ◽  
Hiroshi Imamura ◽  
...  
Keyword(s):  
Interaction Potential ◽  
Potential Surface ◽  
Polymeric Micelles ◽  
High Drug
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