scholarly journals PCOS Features and Steroid Profiles Among Young Adult Women with a History of Premature Adrenarche

2021 ◽  
Author(s):  
Jussi Tennilä ◽  
Jarmo Jääskeläinen ◽  
Pauliina Utriainen ◽  
Raimo Voutilainen ◽  
Merja Häkkinen ◽  
...  
Keyword(s):  
Young Adult ◽  
Ovarian Function ◽  
Polycystic Ovary ◽  
Sex Hormone Binding Globulin ◽  
Hormonal Contraceptives ◽  
Adult Women ◽  
Young Adult Women ◽  
Premature Adrenarche ◽  
Steroid Profiles ◽  
History Of

Abstract Context Premature adrenarche (PA) may increase the risk for polycystic ovary syndrome (PCOS). Objective To study features of PCOS in young adult women with a history of PA. Design and participants Thirty PA and forty-two control females were followed from prepuberty to young adulthood (median age 18.1 years). Main outcome measures Ovarian function, the use of contraceptives, and clinical and biochemical indicators of hyperandrogenism. Results We found no differences in the use of hormonal contraceptives (50 vs 50%, PA vs controls, respectively; P > .999), indication for using contraceptives (P = .193), or in the history of oligo- (17 vs 26%, P = .392) and amenorrhea (0 vs 0%, P > .999). Among women not using hormonal contraceptives, those with a history of PA had a higher prevalence of hirsutism (27 vs 0%, P = .023) but not acne (87 vs 67%, P = .252). Steroid profiles were broadly comparable between the groups, but PA women had lower sex hormone-binding globulin (SHBG) concentrations (30.1 vs 62.4 nmol/l, P < .001) resulting in higher free androgen index (3.94 vs 2.14, P < .001). The difference in SHBG levels persisted through BMI adjustment. SHBG correlated negatively with HOMA-IR (r -0.498, P = .003). Anti-Mullerian hormone concentrations were comparable between the groups (39.3 vs. 32.1 pmol/l, P = .619). Conclusions PA was not associated with evident ovarian dysfunction in young adult women. However, women with a history of PA had decreased SHBG levels and thus, increased bioavailability of circulating androgens.

Ovarian Function Following Pelvic Irradiation in Prepubertal and Pubertal Girls and Young Adult Women

2005 ◽  
Vol 181 (8) ◽  
pp. 534-539 ◽  
Author(s):  
Andreas Schuck ◽  
Victoria Hamelmann ◽  
Jürgen H. Brämswig ◽  
Stefan Könemann ◽  
Claudia Rübe ◽  
...  
Keyword(s):  
Young Adult ◽  
Ovarian Function ◽  
Adult Women ◽  
Pelvic Irradiation ◽  
Young Adult Women

scholarly journals Heightened risk of pain in young adult women with a history of childhood maltreatment

Pain ◽  
2020 ◽  
Vol 161 (1) ◽  
pp. 156-165 ◽  
Author(s):  
Sarah J. Beal ◽  
Susmita Kashikar-Zuck ◽  
Christopher King ◽  
William Black ◽  
Jaclyn Barnes ◽  
...  
Keyword(s):  
Young Adult ◽  
Childhood Maltreatment ◽  
Adult Women ◽  
Young Adult Women ◽  
History Of Childhood ◽  
History Of

scholarly journals Oral Versus Vaginal Combined Hormonal Contraceptives' Effect on Coagulation and Inflammatory Biomarkers Among Young Adult Women

2012 ◽  
Vol 18 (5) ◽  
pp. 487-494 ◽  
Author(s):  
Afshin A. Divani ◽  
Xianghua Luo ◽  
Kyle R. Brandy ◽  
Rachel M. Meyer ◽  
Marilyn S. Joseph ◽  
...  
Keyword(s):  
Young Adult ◽  
Inflammatory Biomarkers ◽  
Hormonal Contraceptives ◽  
Adult Women ◽  
Young Adult Women ◽  
Combined Hormonal Contraceptives

scholarly journals Development and Effects of College-Based Lifestyle Modification Program for Menstrual Health of Young Adult Women with Irregular Menses: A Randomized Controlled Trial

2020 ◽  
Vol 18 (1) ◽  
pp. 233
Author(s):  
Young-Joo Park ◽  
Hyunjeong Shin ◽  
Songi Jeon ◽  
Inhae Cho ◽  
Hyun Ji Park
Keyword(s):  
Young Adult ◽  
Sleep Duration ◽  
Primary Outcome ◽  
Lifestyle Modification ◽  
Controlled Trial ◽  
Sex Hormone Binding Globulin ◽  
Adult Women ◽  
Young Adult Women ◽  
Free Androgen Index ◽  
Lifestyle Modification Program

Purpose: This study was conducted to develop the ‘College-based Lifestyle Modification Program’ (College-based LMP) for young adult women with irregular menstruation and examine its effects after intervention. Methods: The College-based LMP consisted of small group education, individual physical exercise counseling/training, individual diet counseling, and feedback and support. Participants were comprised of 38 females who reported less than 10 irregular menstruations in a year and were randomly assigned to the experimental and control groups. The primary outcome variables consisted of menstrual cycle index (MCI), sex hormone binding globulin (SHBG), and androgenic profile (testosterone—T, free androgen index—FAI), while the outcome variables included premenstrual symptoms (PMS), menstrual volume, body composition parameters, glycemic parameters (fasting blood sugar—FBS, insulin, HOMA-IR), sleep duration, perceived stress, and nutrient intake.. Results: There were no significant differences in primary outcome variables (MCI, SHBG, T, and FAI). In the variables, there were no significant differences except for the partial domain of PMS (symptoms of depression and anxiety) and sleep duration. Conclusions: The study was significant in that it demonstrated the importance of lifestyle, which could provide ordinary young adult women with healthy menstruation. The College-based LMP needs to be elaborated with further studies.

"It Was like a Partnership of the Two of Us Against the Cutting": Investigating the Counseling Experiences of Young Adult Women Who Self-Injure

2008 ◽  
Vol 31 (1) ◽  
pp. 76-94 ◽  
Author(s):  
Laurie Craigen ◽  
Victoria Foster
Keyword(s):  
Young Adult ◽  
Qualitative Study ◽  
Adult Women ◽  
Young Adult Women ◽  
Self Injury ◽  
History Of

Self-injury is an increasing phenomenon among young adult women. This qualitative study explored the counseling experiences of 10 young adult women with a history of self-injurious behavior. It examined the nature of the client-counselor relationship and how self-injury was treated. It also accessed the participants' thoughts and feelings about their experiences in counseling. Implications for training and treatment are set out, as are recommendations for research.

Combined Oral Contraceptive in Adolescent and Young Adult Women: Current Evidence and Future Perspectives

2019 ◽  
Vol 15 (2) ◽  
pp. 109-118 ◽  
Author(s):  
Agnese Maria Chiara Rapisarda ◽  
Roberta Brescia ◽  
Fabrizio Sapia ◽  
Gaetano Valenti ◽  
Giuseppe Sarpietro ◽  
...  
Keyword(s):  
Oral Contraceptive ◽  
Young Adult ◽  
Young Women ◽  
Adolescent And Young Adult ◽  
Current Evidence ◽  
Hormonal Contraceptives ◽  
Adult Women ◽  
Care Providers ◽  
Young Adult Women ◽  
Irregular Bleeding

Background:The use of effective contraceptive methods must be encouraged among adolescents, not only to prevent unintended pregnancies but also to promote the sexual health and well-being of these young people. In effect, hormonal contraceptives offer several benefits beyond prevention of pregnancy to every woman, in particular to adolescents (e.g., dysmenorrhea, irregular bleeding, hirsutism, acne); moreover, they can be a targeted therapy for some gynecological diseases (e.g., endometriosis, polycystic ovary syndrome), to ensure a better quality of life.Objective:The purpose of this article is to review the different formulations of COCs for adolescent and young adult women, and analyze their efficacy, safety, and benefits of specific pathological conditions.Methods:We screened published literature on PubMed/MEDLINE and Scopus, using as keywords “oral contraceptive” in adolescent and young adult women. We included only articles in English about the COCs, different regimens and formulations.Results:Our literature analysis allows us to underline the important role of COC not only as birth control method, but also as valid treatments for gynecological disorders related to hormonal fluctuations (e.g., dysmenorrhea, irregular bleeding, hirsutism, acne) and pathological diseases, such as polycystic ovarian syndrome (PCOS), endometriosis, with a preventive role for fertility preservation and pelvic inflammatory disease.Conclusion:Adequate, care and competent counseling is the key to achieve good compliance of young women with contraception. Through the “GATHER” method suggested by WHO, health care providers should first evaluate the balance between benefits and risks of hormonal treatment, create an appropriate safety profile and then recommend COC prescription in adolescent and young women.

scholarly journals 11-Oxygenated C19 Steroids Do Not Distinguish the Hyperandrogenic Phenotype of PCOS Daughters from Girls with Obesity

2020 ◽  
Vol 105 (11) ◽  
Author(s):  
Laura C Torchen ◽  
Ryan Sisk ◽  
Richard S Legro ◽  
Adina F Turcu ◽  
Richard J Auchus ◽  
...  
Keyword(s):  
Polycystic Ovary ◽  
Medical Center ◽  
Academic Medical Center ◽  
Tanner Stage ◽  
Sex Hormone Binding Globulin ◽  
Ovary Syndrome ◽  
Lean Control ◽  
Academic Medical ◽  
Steroid Profiles ◽  
History Of

Abstract Context Hyperandrogenemia (HA) is a consistent reproductive phenotype in women with polycystic ovary syndrome (PCOS) and their relatives. Increased testosterone levels are present in premenarchal daughters of affected women (PCOS-d). Obese girls (OB-g) without a family history of PCOS also have peripubertal HA. The sources and significance of HA in these groups remains unknown. Objective 11-oxygenated 19-carbon (C19) steroids are adrenally derived androgens that are elevated in hyperandrogenic disorders, including PCOS. We performed this study to test the hypothesis that peripheral serum 11-oxygenated steroids would differ in PCOS-d compared with OB-g suggesting distinct etiologies of HA in affected girls. Design, Setting, and Participants We compared peripheral serum 11-oxygenated steroid levels in 21 PCOS-d, 29 OB-g, and 17 lean control girls (LC) of comparable age at an academic medical center. Results Body mass index (BMI) differed by design (P < 0.001). 11β-hydroxyandrostenedione, 11-ketoandrostenedione, and 11β-hydroxytestosterone levels did not differ between the groups. Compared with LC, PCOS-d and OB-g had similar elevations in 11-ketotestosterone (11KT) (analysis of variance [ANOVA] P = 0.03; PCOS-d vs LC, P = 0.04; OB-g vs LC, P = 0.05; PCOS-d vs OB-g, P = 0.97). In multivariate regression, 11KT levels were associated with DHEAS (P = 0.008), but not with BMI z score, breast Tanner stage, testosterone, anti-Müllerian hormone or sex hormone–binding globulin levels. Conclusions Circulating 11KT levels were similarly elevated in peripubertal PCOS-d and OB-g, suggesting an adrenal component of HA in both groups. We found that 11-oxygenated 19-carbon steroid profiles did not identify subtypes of HA girls.

Unfavorable Hormonal and Psychologic Profile in Adult Women with a History of Premature Adrenarche and Pubarche, Compared to Women with Polycystic Ovary Syndrome

2020 ◽  
Vol 52 (03) ◽  
pp. 179-185 ◽  
Author(s):  
Sarantis Livadas ◽  
Christina Bothou ◽  
Christina Kanaka-Gantenbein ◽  
Dimitrios Chiotis ◽  
Nicholas Angelopoulos ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Resistance Index ◽  
Pubic Hair ◽  
Adult Women ◽  
Ovary Syndrome ◽  
Eating Disorder Symptoms ◽  
Premature Adrenarche ◽  
Increased Risk ◽  
History Of

AbstractIf circulating adrenal androgens levels rise before the age of 8 years in girls, this phenomenon is termed premature adrenarche (PA), while the concomitant appearance of pubic hair is called premature pubarche (PP). Girls with PA-PP display an unfavorable hormonal profile compared to their normal peers and have an increased risk of developing polycystic ovary syndrome (PCOS) features peripubertally. However, the sequelae of premature adrenarche remains unclear. We assessed metabolic, hormonal, psychologic profiles, and ovarian morphology in 21 women of mean age (±SD) 21.3±3.3 years, BMI: 23.6±4.4 kg/m2 with PA-PP, 45 women with PCOS and 26 controls, matched for age and BMI. PA-PP women displayed a favorable lipid profile compared to PCOS and controls. Insulin resistance index (HOMA-IR), however, were similar in PA-PP and PCOS women (2.09±1.42, 2.08±0.83) and higher than controls (1.13±0.49, p <0.05). Circulating androstenedione levels did not differ between PA-PP and PCOS women (0.11±0.05 vs. 0.12±0.03), but was higher than that of controls (0.02±0.0 nmol/l, p <0,05). Ovarian volume was increased in PA-PP and PCOS (11.14±3.3 vs. 10.99±4.61) compared to controls (6.74±1.83 cm3). PA-PP women had a higher score of state/trait anxiety and depressive and eating disorder symptoms than controls, with a pattern that matched that of PCOS women. Only 14% of the PA-PP group fulfilled the Rotterdam PCOS criteria. Some women with a history of PA-PP displayed hormonal and psychologic profile similar to PCOS, and accordingly a regular monitoring of these girls during adulthood is advised.

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