Effect of in vivo administration of recombinant acidic fibroblast growth factor on thyroid function in the rat: induction of colloid goiter

Endocrinology ◽  
1992 ◽  
Vol 131 (2) ◽  
pp. 729-735 ◽  
Author(s):  
W. J. De Vito
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Thyroid Function ◽  
Fibroblast Growth ◽  
Acidic Fibroblast Growth Factor ◽  
In Vivo Administration

Acidic Fibroblast Growth Factor Enhances Peripheral Nerve Regeneration in Vivo

1989 ◽  
Vol 83 (6) ◽  
pp. 1020-1021 ◽  
Author(s):  
Peter G. Cordeiro ◽  
Brooke R. Seckel ◽  
Stuart A. Lipton ◽  
Patricia A. DʼAmore ◽  
John Wagner ◽  
...  
Keyword(s):  
Growth Factor ◽  
Peripheral Nerve ◽  
Nerve Regeneration ◽  
Fibroblast Growth Factor ◽  
Peripheral Nerve Regeneration ◽  
Fibroblast Growth ◽  
Acidic Fibroblast Growth Factor

Acidic fibroblast growth factor modulates gene expression in the rat thyroid in vivo

1992 ◽  
Vol 50 (4) ◽  
pp. 392-399 ◽  
Author(s):  
Jean-Pierre Chanoine ◽  
Lewis E. Braverman ◽  
William J. DeVito ◽  
Gary S. Stein ◽  
Victoria Shalhoub ◽  
...  
Keyword(s):  
Gene Expression ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Fibroblast Growth ◽  
Acidic Fibroblast Growth Factor ◽  
Rat Thyroid

In vivo activities of acidic fibroblast growth factor-Pseudomonas exotoxin fusion proteins

1994 ◽  
Vol 5 (1) ◽  
pp. 77-83 ◽  
Author(s):  
Clay B. Siegall ◽  
Susan L. Gawlak ◽  
Dana F. Chace ◽  
June R. Merwin ◽  
Ira Pastan
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Fusion Proteins ◽  
Fibroblast Growth ◽  
Acidic Fibroblast Growth Factor ◽  
Pseudomonas Exotoxin

In vitro lens transdifferentiation of Xenopus laevis outer cornea induced by Fibroblast Growth Factor (FGF)

Development ◽  
1997 ◽  
Vol 124 (2) ◽  
pp. 421-428
Author(s):  
L. Bosco ◽  
G. Venturini ◽  
D. Willems
Keyword(s):  
Growth Factor ◽  
Xenopus Laevis ◽  
Fibroblast Growth Factor ◽  
Specific Inhibitor ◽  
Bovine Brain ◽  
Fibroblast Growth ◽  
Acidic Fibroblast Growth Factor ◽  
Lens Fibers

It has been shown that lens regeneration from outer cornea of larval Xenopus laevis is dependent on neural retina both in vivo and in tissue culture. The isolated outer cornea cultured in the presence of bovine brain-derived acidic Fibroblast Growth Factor (aFGF) is able to reprogram the differentiation into lens fibers, although this transdifferentiative process is not coupled with the formation of a normally organized lens. The capacity of aFGF to promote lens differentiation from cornea is not linked to its mitogenic activity. The cultured corneal cells can transdifferentiate into lens fibers in the presence of aFGF when DNA replication and cell proliferation are prevented by addition of aphidicolin, a specific inhibitor of DNA polymerase in eukaryotes, to the culture medium.

Capillary endothelial cells secrete a heparin-binding mitogen for pericytes

1992 ◽  
Vol 103 (2) ◽  
pp. 453-461
Author(s):  
J.C. Swinscoe ◽  
E.C. Carlson
Keyword(s):  
Endothelial Cells ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Fibroblast Growth ◽  
Heparin Binding ◽  
Acidic Fibroblast Growth Factor ◽  
Phenotypic Characteristics ◽  
Retinal Microvasculature ◽  
Capillary Endothelial Cells

The cells of the retinal microvasculature consist predominantly of mesodermally derived pericytes and endothelial cells, and the regulatory factors which govern their co-ordinated growth and define their phenotypic characteristics in vivo may be regarded as key elements of the angiogenic process. An investigation of these cells in co-culture experiments has led to the identification of a potent mitogen for pericytes in medium conditioned by retinal endothelial cells (EC-FBS). EC-FBS activity was shown to be non-dialyzable, and stable to both heat and acid treatment. EC-FBS was inactivated by passage over a heparin-Agarose column. The column-bound activity could be eluted as a single peak at approximately 1.0 M NaCl. Stimulation of pericyte growth was also achieved with platelet-derived growth factor (PDGF), acidic fibroblast growth factor (aFGF) and basic fibroblast growth factor (bFGF) and could be blocked by using the appropriate antiserum (anti-PDGF or anti-aFGF). Neither antisera, however, blocked the activity of EC-FBS. The EC-FBS mitogen markedly altered the phenotypic behavior of pericytes compared with PDGF and the FGFs; yet, unlike them, it failed to stimulate the growth of smooth muscle cells (SMC) and Balb/c 3T3 cells.

In Vivo Angiogenesis Induced by Recombinant Adenovirus Vectors Coding Either for Secreted or Nonsecreted Forms of Acidic Fibroblast Growth Factor

1995 ◽  
Vol 6 (11) ◽  
pp. 1457-1465 ◽  
Author(s):  
Judith Mühlhauser ◽  
Roberto Pili ◽  
Marsha J. Merrill ◽  
Hiroyuki Maeda ◽  
Antonino Passaniti ◽  
...  
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Recombinant Adenovirus ◽  
Fibroblast Growth ◽  
Acidic Fibroblast Growth Factor ◽  
Adenovirus Vectors
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