scholarly journals Maternal High-Fat Diet Disturbs Uteroplacental Hemodynamics and Increases the Frequency of Stillbirth in a Nonhuman Primate Model of Excess Nutrition

Endocrinology ◽  
2011 ◽  
Vol 152 (6) ◽  
pp. 2456-2464 ◽  
Author(s):  
Antonio E. Frias ◽  
Terry K. Morgan ◽  
Anne E. Evans ◽  
Juha Rasanen ◽  
Karen Y. Oh ◽  
...  
Keyword(s):  
Nonhuman Primate ◽  
High Fat Diet ◽  
High Fat ◽  
Nonhuman Primate Model ◽  
Primate Model

Maternal High-Fat Diet Persistently Alters Bone Marrow Immune Cell Proportions and Function in a Nonhuman Primate Model

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 222-OR
Author(s):  
MICHAEL J. NASH ◽  
TAYLOR K. SODERBORG ◽  
RACHEL C. JANSSEN ◽  
ERIC M. PIETRAS ◽  
JACOB E. FRIEDMAN
Keyword(s):  
Bone Marrow ◽  
Nonhuman Primate ◽  
High Fat Diet ◽  
Immune Cell ◽  
High Fat ◽  
Nonhuman Primate Model ◽  
Primate Model ◽  
And Function

Maternal High-Fat Diet Disturbs Uteroplacental Hemodynamics and Increases the Frequency of Stillbirth in a Nonhuman Primate Model of Excess Nutrition

2011 ◽  
Vol 66 (10) ◽  
pp. 605-606
Author(s):  
Antonio E. Frias ◽  
Terry K. Morgan ◽  
Anne E. Evans ◽  
Juha Rasanen ◽  
Karen Y. Oh ◽  
...  
Keyword(s):  
Nonhuman Primate ◽  
High Fat Diet ◽  
High Fat ◽  
Nonhuman Primate Model ◽  
Primate Model

scholarly journals Maternal High-Fat Diet Modulates the Fetal Thyroid Axis and Thyroid Gene Expression in a Nonhuman Primate Model

2012 ◽  
Vol 26 (12) ◽  
pp. 2071-2080 ◽  
Author(s):  
Melissa A. Suter ◽  
Haleh Sangi-Haghpeykar ◽  
Lori Showalter ◽  
Cynthia Shope ◽  
Min Hu ◽  
...  
Keyword(s):  
Gene Expression ◽  
Nonhuman Primate ◽  
High Fat Diet ◽  
High Fat ◽  
Nonhuman Primate Model ◽  
Primate Model ◽  
Fetal Thyroid ◽  
Thyroid Axis

scholarly journals Maternal high-fat diet reversal improves placental hemodynamics in a nonhuman primate model of diet-induced obesity

2018 ◽  
Vol 43 (4) ◽  
pp. 906-916 ◽  
Author(s):  
Jennifer A. Salati ◽  
Victoria H. J. Roberts ◽  
Matthias C. Schabel ◽  
Jamie O. Lo ◽  
Christopher D. Kroenke ◽  
...  
Keyword(s):  
Nonhuman Primate ◽  
High Fat Diet ◽  
High Fat ◽  
Nonhuman Primate Model ◽  
Primate Model ◽  
Diet Induced Obesity

scholarly journals Maternal and postnatal high-fat diet consumption programs energy balance and hypothalamic melanocortin signaling in nonhuman primate offspring

2017 ◽  
Vol 313 (2) ◽  
pp. R169-R179 ◽  
Author(s):  
Elinor L. Sullivan ◽  
Heidi M. Rivera ◽  
Cadence A. True ◽  
Juliana G. Franco ◽  
Karalee Baquero ◽  
...  
Keyword(s):  
Body Weight ◽  
Energy Balance ◽  
Nonhuman Primate ◽  
High Fat Diet ◽  
Control Diet ◽  
High Fat ◽  
Melanocortin System ◽  
Juvenile Period ◽  
Primate Model ◽  
Related Peptide

Maternal high-fat-diet (HFD) consumption during pregnancy decreased fetal body weight and impacted development of hypothalamic melanocortin neural circuitry in nonhuman primate offspring. We investigated whether these impairments during gestation persisted in juvenile offspring and examined the interaction between maternal and early postnatal HFD consumption. Adult dams consumed either a control diet (CTR; 15% calories from fat) or a high-saturated-fat diet (HFD; 37% calories from fat) during pregnancy. Offspring were weaned onto a CTR or HFD at ~8 mo of age. Offspring from HFD-fed dams displayed early catch-up growth and elevated body weight at 6 and 13 mo of age. Maternal and postnatal HFD exposure reduced the amount of agouti-related peptide fibers in the paraventricular nucleus of the hypothalamus. Postnatal HFD consumption also decreased the amount of agouti-related peptide fibers in the arcuate nucleus of the hypothalamus. Postnatal HFD was associated with decreased food intake and increased activity. These results support and extend our previous findings of maternal diet effects on fetal development and reveal, for the first time in a nonhuman primate model, that maternal HFD-induced disturbances in offspring body weight regulation extended past gestation into the juvenile period. Maternal HFD consumption increases the risk for offspring developing obesity, with the developmental timing of HFD exposure differentially impacting the melanocortin system and energy balance regulation. The present findings provide translational insight into human clinical populations, suggesting that profound health consequences may await individuals later in life following intrauterine and postnatal HFD exposure.

scholarly journals Reperfusion plus Selective Intra-arterial Cooling (SI-AC) Improve Recovery in a Nonhuman Primate Model of Stroke

2020 ◽  
Author(s):  
Di Wu ◽  
Yongjuan Fu ◽  
Longfei Wu ◽  
Mitchell Huber ◽  
Jian Chen ◽  
...  
Keyword(s):  
Nonhuman Primate ◽  
Nonhuman Primate Model ◽  
Primate Model

Robotic Assessment of Upper Limb Function in a Nonhuman Primate Model of Chronic Stroke

2021 ◽  
Author(s):  
Yining Chen ◽  
Meredith C. Poole ◽  
Shelby V. Olesovsky ◽  
Allen A. Champagne ◽  
Kathleen A. Harrison ◽  
...  
Keyword(s):  
Upper Limb ◽  
Nonhuman Primate ◽  
Chronic Stroke ◽  
Nonhuman Primate Model ◽  
Limb Function ◽  
Primate Model ◽  
Upper Limb Function

scholarly journals Transcriptomic phases of periodontitis lesions using the nonhuman primate model

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Jeffrey L. Ebersole ◽  
Radhakrishnan Nagarajan ◽  
Sreenatha Kirakodu ◽  
Octavio A. Gonzalez
Keyword(s):  
Gene Expression ◽  
Nonhuman Primate ◽  
Gingival Crevicular Fluid ◽  
Inflammatory Responses ◽  
Expression Profiles ◽  
Lesion Detection ◽  
Gingival Tissue ◽  
Specific Gene ◽  
Nonhuman Primate Model ◽  
Primate Model

AbstractWe used a nonhuman primate model of ligature-induced periodontitis to identify patterns of gingival transcriptomic after changes demarcating phases of periodontitis lesions (initiation, progression, resolution). A total of 18 adult Macaca mulatta (12–22 years) had ligatures placed (premolar, 1st molar teeth) in all 4 quadrants. Gingival tissue samples were obtained (baseline, 2 weeks, 1 and 3 months during periodontitis and at 5 months resolution). Gene expression was analyzed by microarray [Rhesus Gene 1.0 ST Array (Affymetrix)]. Compared to baseline, a large array of genes were significantly altered at initiation (n = 6049), early progression (n = 4893), and late progression (n = 5078) of disease, with the preponderance being up-regulated. Additionally, 1918 genes were altered in expression with disease resolution, skewed towards down-regulation. Assessment of the genes demonstrated specific profiles of epithelial, bone/connective tissue, apoptosis/autophagy, metabolism, regulatory, immune, and inflammatory responses that were related to health, stages of disease, and tissues with resolved lesions. Unique transcriptomic profiles occured during the kinetics of the periodontitis lesion exacerbation and remission. We delineated phase specific gene expression profiles of the disease lesion. Detection of these gene products in gingival crevicular fluid samples from human disease may contribute to a better understanding of the biological dynamics of the disease to improve patient management.

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