Long-term treatment with a glucagon-like peptide-1 receptor agonist reduces ethanol intake in male and female rats

ABSTRACT The influence on the I. C. S. H.-content of the pituitary gland and the blood serum of long-term treatment of gonadectomized male and female rats with several low doses of oestradiol benzoate was investigated. It was found that only in females treatment with 0.1 and 0.2 μg of oestradiol benzoate daily results in an increase of the pituitary I. C. S. H.-content, whereas in the serum content a (non-significant) decrease was observed. In male rats the pituitary I. C. S. H.-content was not influenced by treatment with these doses, but the serum content decreased. Higher doses of oestradiol (0.5 and 2.0 μg daily) caused, both in males and in females, a decrease of the I. C. S. H.-content in the hypophysis as well as in the serum. It is assumed that oestrogen, if chronically administered, exerts two different actions on pituitary I. C. S. H.: it depresses the production of I. C. S. H. and inhibits the release. In females, these two effects have different threshold levels, that for the release being the lower one. In males the threshold for the inhibition of production has to be lower.

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INFLUENCE OF GONADAL HORMONES ON THE ACTION OF CALCITONIN IN THE RAT

Acta Endocrinologica ◽

10.1530/acta.0.0680585 ◽

1971 ◽

Vol 68 (3) ◽

pp. 585-596 ◽

Cited By ~ 3

Author(s):

O. Helmer Serensen ◽

Inge Hindberg

Keyword(s):

Serum Calcium ◽

Thyroid Tissue ◽

Gonadal Hormones ◽

Term Treatment ◽

Female Rats ◽

Short Term ◽

Oestrogen Treatment ◽

Male And Female Rats ◽

Long Term Treatment

ABSTRACT The influence of short-term and long-term treatment with gonadal hormones on the response to calcitonin was investigated in the rat. Oestrogen-treatment, short-term as well as long-term, resulted in a reduced responsiveness to calcitonin. Long-term treatment with androgens enhanced the hypocalcaemic effect of calcitonin in castrated rats of either sex, but reduced the effect in intact animals. No sex differences could be registered in the sensitivity to calcitonin, when intact animals were compared according to age, while marked differences were observed, when the animals were compared according to weight. There was a linear decrease in the response to calcitonin with increasing age in rats of both sexes. An intraperitoneal calcium load was followed by an acute rise in the serum calcium levels. The adult animals counteracted the hypercalcaemia more slowly than the young ones. Significant differences also occurred between male and female rats, the rise in the serum calcium concentration being much more pronounced in the latter group. The hypocalcaemic activity of thyroid tissue from rats of both sexes and of various ages showed considerable variations, but no differences correlated to age or sex.

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Long-Term Treatment of Glucagon-Like Peptide-1 Analog Exendin-4 Ameliorates Diabetic Nephropathy through Improving Metabolic Anomalies in db/db Mice

Journal of the American Society of Nephrology ◽

10.1681/asn.2006070778 ◽

2007 ◽

Vol 18 (4) ◽

pp. 1227-1238 ◽

Cited By ~ 140

Author(s):

Cheol Whee Park ◽

Hyeong Wook Kim ◽

Seung Hyun Ko ◽

Ji Hee Lim ◽

Gyeong Ryul Ryu ◽

...

Keyword(s):

Diabetic Nephropathy ◽

Term Treatment ◽

Long Term Treatment ◽

Glucagon Like Peptide ◽

Glucagon Like Peptide 1

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Effects of short-term and long-term androgen treatment on the diaphragm in male and female rats

Journal of Applied Physiology ◽

10.1152/jappl.1993.75.3.1140 ◽

1993 ◽

Vol 75 (3) ◽

pp. 1140-1149 ◽

Cited By ~ 19

Author(s):

D. J. Prezant ◽

D. E. Valentine ◽

E. I. Gentry ◽

B. Richner ◽

J. Cahill ◽

...

Keyword(s):

Fatigue Resistance ◽

Fiber Type ◽

Female Rats ◽

Short Term ◽

Male And Female ◽

Testosterone Treatment ◽

Male And Female Rats ◽

Long Term Treatment ◽

Significant Difference

The effects of short-term (2.5 wk) and long-term (10 wk) testosterone propionate (2.5 mg/day; 5 days/wk) treatment on diaphragm contractility, fatigue resistance, and fiber type proportions were studied in male and female rats. Contractility and fatigue resistance indexes were measured in an in vitro diaphragm costal strip preparation by direct stimulation at 37 degrees C. The fatigue paradigm consisted of 30 trains/min at 5 Hz (50% duty cycle) for 10 min. Fatigue resistance indexes were calculated as postfatigue divided by baseline forces. In females but not males, testosterone treatment produced significant increases in body weight, costal diaphragm weight, and contractility and significant decreases in fatigue resistance indexes. The interaction between testosterone treatment and the duration of treatment was significant, with the increase in contractility (females) being significant after short-term but not long-term treatment. No significant difference in fiber type proportions or areas was observed, regardless of treatment duration or the preexperimental, basal circulating level of androgen.

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