Topographic Analysis of the α-Subunit of Human Follicle-Stimulating Hormone using Site-Specific Antipeptide Antisera*

Endocrinology ◽  
1990 ◽  
Vol 127 (2) ◽  
pp. 573-579 ◽  
Author(s):  
RUSSELL S. WEINER ◽  
THOMAS T. ANDERSEN ◽  
JAMES A. DIAS
Keyword(s):  
Follicle Stimulating Hormone ◽  
Topographic Analysis ◽  
Α Subunit ◽  
Site Specific ◽  
Stimulating Hormone

scholarly journals Total Synthesis of the α-Subunit of Human Glycoprotein Hormones: Toward Fully Synthetic Homogeneous Human Follicle-Stimulating Hormone

2012 ◽  
Vol 134 (7) ◽  
pp. 3532-3541 ◽  
Author(s):  
Baptiste Aussedat ◽  
Bernhard Fasching ◽  
Eric Johnston ◽  
Neeraj Sane ◽  
Pavel Nagorny ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Follicle Stimulating Hormone ◽  
Glycoprotein Hormones ◽  
Α Subunit ◽  
Stimulating Hormone

scholarly journals Molecular regulation of follicle-stimulating hormone synthesis, secretion and action

2018 ◽  
Vol 60 (3) ◽  
pp. R131-R155 ◽  
Author(s):  
Nandana Das ◽  
T Rajendra Kumar
Keyword(s):  
Molecular Mechanisms ◽  
Follicle Stimulating Hormone ◽  
Thyroid Stimulating Hormone ◽  
Α Subunit ◽  
Physiological Regulation ◽  
Hormone Synthesis ◽  
The Common ◽  
Blocking Antibodies ◽  
Recombinant Human Fsh ◽  
Stimulating Hormone

Follicle-stimulating hormone (FSH) plays fundamental roles in male and female fertility. FSH is a heterodimeric glycoprotein expressed by gonadotrophs in the anterior pituitary. The hormone-specific FSHβ-subunit is non-covalently associated with the common α-subunit that is also present in the luteinizing hormone (LH), another gonadotrophic hormone secreted by gonadotrophs and thyroid-stimulating hormone (TSH) secreted by thyrotrophs. Several decades of research led to the purification, structural characterization and physiological regulation of FSH in a variety of species including humans. With the advent of molecular tools, availability of immortalized gonadotroph cell lines and genetically modified mouse models, our knowledge on molecular mechanisms of FSH regulation has tremendously expanded. Several key players that regulate FSH synthesis, sorting, secretion and action in gonads and extragonadal tissues have been identified in a physiological setting. Novel post-transcriptional and post-translational regulatory mechanisms have also been identified that provide additional layers of regulation mediating FSH homeostasis. Recombinant human FSH analogs hold promise for a variety of clinical applications, whereas blocking antibodies against FSH may prove efficacious for preventing age-dependent bone loss and adiposity. It is anticipated that several exciting new discoveries uncovering all aspects of FSH biology will soon be forthcoming.

FSH in therapy: physiological basis, new preparations and clinical use

1995 ◽  
Vol 4 (3) ◽  
pp. 163-177 ◽  
Author(s):  
Manuela Simoni ◽  
Eberhard Nieschlag
Keyword(s):  
Follicle Stimulating Hormone ◽  
Thyroid Stimulating Hormone ◽  
Clinical Use ◽  
Β Subunit ◽  
Glycoprotein Hormone ◽  
Physiological Basis ◽  
Α Subunit ◽  
And Function ◽  
Polypeptide Chains ◽  
Stimulating Hormone

Follicle stimulating hormone (FSH) is a glycoprotein hormone secreted by the pituitary gland that, together with luteinizing hormone (LH), controls development, maturation and function of the gonad. Like the related hormones, LH, thyroid stimulating hormone (TSH) and human chorionic gonadotropin (hCG), FSH consists of two polypeptide chains, α and β, bearing carbohydrate moietiesN-linked to asparagine (Asn) residues. The α subunit is common to all members of the glycoprotein hormone family, whereas the β subunit, although structurally very similar, differs in each hormone and confers specificity of action.

hCG production and activity during pregnancy

2001 ◽  
Vol 12 (3) ◽  
pp. 191-208 ◽  
Author(s):  
H S Randeva ◽  
A Jackson ◽  
E Karteris ◽  
E W Hillhouse
Keyword(s):  
Luteinizing Hormone ◽  
Chorionic Gonadotropin ◽  
Essential Role ◽  
Follicle Stimulating Hormone ◽  
Thyroid Stimulating Hormone ◽  
Β Subunit ◽  
Glycoprotein Hormone ◽  
Α Subunit ◽  
Hormone Specificity ◽  
Stimulating Hormone

Human chorionic gonadotropin (hCG) has an essential role in early pregnancy. It is a member of the glycoprotein hormone family also comprising the pituitary derived follicle stimulating hormone (FSH), luteinizing hormone (LH) and thyroid stimulating hormone (TSH). Each hormone consists of a non-covalently bound α and β subunit. Within a species the α subunit is identical and hormone specificity is determined by the unique β subunit.

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