Effects of RNA and Protein Synthesis Inhibitors on Preinduced Levels of Rat Uterine Glucose–6–Phosphate Dehydrogenase

Endocrinology ◽  
1972 ◽  
Vol 91 (2) ◽  
pp. 491-498 ◽  
Author(s):  
BRUCE C. MOULTON ◽  
KENNETH L. BARKER
Keyword(s):  
Protein Synthesis ◽  
Protein Synthesis Inhibitors ◽  
Rna And Protein Synthesis ◽  
Glucose 6 Phosphate Dehydrogenase

scholarly journals Induction of N-acetylglucosamine kinase in yeast

1974 ◽  
Vol 141 (2) ◽  
pp. 593-595 ◽  
Author(s):  
A. Bhattacharya ◽  
M. Puri ◽  
A. Datta
Keyword(s):  
Protein Synthesis ◽  
Enzyme Activity ◽  
Candida Albicans ◽  
Enzyme Synthesis ◽  
Transcriptional Level ◽  
Protein Synthesis Inhibitors ◽  
Rna And Protein Synthesis ◽  
New Protein

The presence of N-acetylglucosamine is essential for the induced synthesis of N-acetylglucosamine kinase in Candida albicans. The enzyme synthesis stops and its concentration in the cells declines rapidly as soon as N-acetylglucosamine is removed from the medium. Experiments with RNA- and protein-synthesis inhibitors indicate that the appearance of new enzyme activity is dependent on concomitant new protein synthesis and the inducer operates at a transcriptional level.

Metabolic requirements for interactions between nuclear and cytoplasmic membranes in the repair of damaged Amoeba nuclei

1976 ◽  
Vol 21 (2) ◽  
pp. 291-302
Author(s):  
C.J. Flickinger
Keyword(s):  
Endoplasmic Reticulum ◽  
Protein Synthesis ◽  
Membrane Fusion ◽  
Energy Production ◽  
Rna Synthesis ◽  
Metabolic Inhibitors ◽  
Protein Synthesis Inhibitors ◽  
Nuclear Membranes ◽  
Cytoplasmic Membranes ◽  
Rna And Protein Synthesis

Amoeba nuclear envelopes were damaged using microsurgery, and metabolic requirements for the steps in their repair were studied, and my placing the cells in a solution containing one of several metabolic inhibitors. The first step in repair, the association of pieces of endoplasmic reticulum with holes in the nuclear membranes, appears to be a passive process since it was not affected by inhibitors of energy production, RNA synthesis, or protein synthesis. In contrast, fusion of pieces of endoplasmic reticulum with the nuclear membranes at the margins of the holes was blocked by KCN and dinitrophenol, indicating that membrane fusion requires energy derived from respiration, but RNA and protein synthesis inhibitors did not prevent fusion of pieces of endoplasmic reticulum with the nuclear membranes. The subsequent completion of repair and restoration of intact nuclear membranes was almost completely blocked by inhibitors of respiration, and it was reduced in the presence of actinomycin and emetine, suggesting that in addition to a requirement for energy, some later steps in the repair of the nuclear membranes require RNA and protein synthesis.

Ultrastructural investigation of the effect of DNA, RNA, and protein synthesis inhibitors on ribosome crystallization

1973 ◽  
Vol 44 (3-4) ◽  
pp. 265-278 ◽  
Author(s):  
Nadir M. Maraldi ◽  
Graziella Biagini ◽  
Paolo Simoni ◽  
Marcello Barbieri ◽  
Marina Marini ◽  
...  
Keyword(s):  
Protein Synthesis ◽  
Protein Synthesis Inhibitors ◽  
Ultrastructural Investigation ◽  
Rna And Protein Synthesis

Influence of aortic coarctation on myocardial glucose-6-phosphate dehydrogenase

1969 ◽  
Vol 47 (4) ◽  
pp. 388-391 ◽  
Author(s):  
J. R. E. Valadares ◽  
R. L. Singhal ◽  
M. R. Parulekar ◽  
Margaret Beznak
Keyword(s):  
Protein Synthesis ◽  
Enzyme Activity ◽  
Cardiac Hypertrophy ◽  
Aortic Coarctation ◽  
Significant Inhibition ◽  
Rna And Protein Synthesis ◽  
Wet Weight ◽  
Glucose 6 Phosphate Dehydrogenase

Alterations in the activity of myocardial glucose-6-phosphate dehydrogenase were studied in rats with experimentally produced cardiac hypertrophy. Six days after aortic coarctation, enzyme activity was increased to more than 200% of the control values when expressed either per gram wet weight or per organ. Administration of cycloheximide resulted in a significant inhibition of the increase in cardiac glucose-6-phosphate dehydrogenase noted after constriction. It is conceivable that the augmentation in the activity of this enzyme may be related to the increases in RNA and protein synthesis observed during development of cardiac hypertrophy.

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