Physiological relevance of tumor necrosis factor in mediating macrophage-Leydig cell interactions.

Endocrinology ◽  
1994 ◽  
Vol 134 (1) ◽  
pp. 63-69 ◽  
Author(s):  
C Moore ◽  
J C Hutson
Keyword(s):  
Tumor Necrosis Factor ◽  
Leydig Cell ◽  
Tumor Necrosis ◽  
Cell Interactions ◽  
Physiological Relevance ◽  
Necrosis Factor

scholarly journals Tumor Necrosis Factor-α Inhibits Leydig Cell Steroidogenesis through a Decrease in Steroidogenic Acute Regulatory Protein Expression1

Endocrinology ◽  
1998 ◽  
Vol 139 (6) ◽  
pp. 2863-2868 ◽  
Author(s):  
Claire Mauduit ◽  
Françoise Gasnier ◽  
Catherine Rey ◽  
Marie-Agnès Chauvin ◽  
Douglas M. Stocco ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Leydig Cell ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Regulatory Protein ◽  
Steroidogenic Acute Regulatory Protein ◽  
Steroidogenic Acute Regulatory ◽  
Factor Α ◽  
Necrosis Factor

scholarly journals Postanoxic T Lymphocyte–Endothelial Cell Interactions Induce Tumor Necrosis Factor-α Production and Neutrophil Adhesion

2000 ◽  
Vol 86 (12) ◽  
pp. 1237-1244 ◽  
Author(s):  
Satoshi Kokura ◽  
Robert E. Wolf ◽  
Toshikazu Yoshikawa ◽  
D. Neil Granger ◽  
Tak Yee Aw
Keyword(s):  
Endothelial Cell ◽  
Tumor Necrosis Factor ◽  
T Lymphocyte ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Cell Interactions ◽  
Neutrophil Adhesion ◽  
Factor Α ◽  
Necrosis Factor

scholarly journals Macrophage-T Cell Interactions Mediate Neuropathic Pain through the Glucocorticoid-induced Tumor Necrosis Factor Ligand System

2015 ◽  
Vol 290 (20) ◽  
pp. 12603-12613 ◽  
Author(s):  
Yuka Kobayashi ◽  
Norikazu Kiguchi ◽  
Yohji Fukazawa ◽  
Fumihiro Saika ◽  
Takehiko Maeda ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
T Cell ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Cell Interactions ◽  
Ligand System ◽  
Tumor Necrosis Factor Ligand ◽  
Necrosis Factor

Monocyte-endothelial cell interactions in vitro, with reference to the influence of interleukin-1 and tumor necrosis factor

1993 ◽  
Vol 79 (1) ◽  
pp. 17-26 ◽  
Author(s):  
Jianglin Fan ◽  
Tatsuro Shimokama ◽  
Seiji Haraoka ◽  
Osamu Tokunaga ◽  
Teruo Watanabe
Keyword(s):  
Endothelial Cell ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Interleukin 1 ◽  
Cell Interactions ◽  
Necrosis Factor

scholarly journals Therapeutic approaches for tumor necrosis factor inhibition

2011 ◽  
Vol 47 (3) ◽  
pp. 427-446 ◽  
Author(s):  
Maria Letícia de Castro Barbosa ◽  
Milla Machado Fumian ◽  
Ana Luísa Palhares de Miranda ◽  
Eliezer J. Barreiro ◽  
Lídia Moreira Lima
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Therapeutic Approaches ◽  
Biological Targets ◽  
Administration Routes ◽  
New Therapeutic Approaches ◽  
Tumor Necrosis Factor Inhibition ◽  
Physiological Relevance ◽  
Orally Active ◽  
Necrosis Factor

Tumor necrosis factor (TNF) consists of an inflammatory cytokine essential for homeostasis and organism defense. Despite its physiological relevance, both increased biosynthesis and release of TNF lead to the exacerbation of inflammatory and oxidative responses, which are related to the pathogenesis of a host of diseases of an inflammatory, autoimmune and/or infectious nature. In this context, effective therapeutic approaches for the modulation of TNF have been the focus of research efforts. Approximately one million individuals worldwide have been treated with biotechnological inhibitors of this cytokine, the so-called anti-TNF biopharmaceuticals. However, given the high risk of infection and the limitations related to cost and administration routes, new therapeutic approaches aimed at biological targets that directly or indirectly modulate the production and/or activation of TNF appear promising alternatives for the discovery of new anti-inflammatory and immunomodulatory orally active drugs and are therefore discussed in this paper.

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