scholarly journals Influence of Growth Hormone (GH) Receptor Deletion of Exon 3 and Full-Length Isoforms on GH Response and Final Height in Patients with Severe GH Deficiency

2008 ◽  
Vol 93 (3) ◽  
pp. 974-980 ◽  
Author(s):  
Barbara Räz ◽  
Marco Janner ◽  
Vibor Petkovic ◽  
Didier Lochmatter ◽  
Andrée Eblé ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Gh Deficiency ◽  
Final Height ◽  
Full Length ◽  
Gh Receptor

scholarly journals Growth Hormone (GH) Pharmacogenetics: Influence of GH Receptor Exon 3 Retention or Deletion on First-Year Growth Response and Final Height in Patients with Severe GH Deficiency

2006 ◽  
Vol 91 (3) ◽  
pp. 1076-1080 ◽  
Author(s):  
Alexander A. L. Jorge ◽  
Frederico G. Marchisotti ◽  
Luciana R. Montenegro ◽  
Luciani R. Carvalho ◽  
Berenice B. Mendonca ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Growth Response ◽  
Gh Deficiency ◽  
Final Height ◽  
First Year ◽  
Gh Receptor

Short‐ and long‐term responsiveness to low dose growth hormone (GH) in adult GH deficiency: Role of GH receptor polymorphism

2019 ◽  
Vol 31 (4) ◽  
pp. e12692 ◽  
Author(s):  
Antonio Bianchi ◽  
Antonella Giampietro ◽  
Linda Tartaglione ◽  
Sabrina Chiloiro ◽  
Raffaella Gentilella ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Low Dose ◽  
Gh Deficiency ◽  
Gh Receptor ◽  
Adult Gh Deficiency ◽  
Short And Long Term ◽  
Receptor Polymorphism

scholarly journals Growth Hormone (GH) Secretion in Patients with Childhood-Onset GH Deficiency: Retesting after One Year of Therapy and at Final Height

2003 ◽  
Vol 59 (1) ◽  
pp. 7-15 ◽  
Author(s):  
M. Thomas ◽  
G. Massa ◽  
M. Maes ◽  
D. Beckers ◽  
M. Craen ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Gh Deficiency ◽  
Final Height ◽  
Childhood Onset ◽  
Gh Secretion ◽  
One Year

scholarly journals Growth Hormone (GH) Treatment Up-Regulates GH Receptor mRNA Levels in Adipocytes from Patients with GH Deficiency and Prader-Willi Syndrome

1995 ◽  
Vol 38 (3) ◽  
pp. 418-421 ◽  
Author(s):  
Ashraf Kamel ◽  
Véronique Margery ◽  
Gunnar Norstedt ◽  
Marja Thorén ◽  
Anne-Christine Lindgren ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Gh Deficiency ◽  
Prader Willi Syndrome ◽  
Mrna Levels ◽  
Gh Treatment ◽  
Receptor Mrna ◽  
Gh Receptor

scholarly journals Final height in isolated GH deficiency type 1A: effects of 5-year treatment with IGF-I

2001 ◽  
pp. 379-383 ◽  
Author(s):  
MF Messina ◽  
F De Luca ◽  
M Wasniewska ◽  
M Valenzise ◽  
F Lombardo ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Gh Deficiency ◽  
Final Height ◽  
Phenotypic Expression ◽  
Hormone Deficiency ◽  
Target Height ◽  
Igf I ◽  
Puberty Onset ◽  
The One ◽  
Deficiency Type

Data concerning final height (FH) in isolated growth hormone deficiency type 1A (IGHD1A) are scanty and controversial. In this paper we report the FH outcome of two girls with IGHD1A who were treated either with GH only (first patient) or with GH during the first 8 years and successively with IGF-I (second patient). In the first patient, FH was only slightly subnormal and slightly taller with respect to target height (TH). Surprisingly, FH was severely subnormal and very far from TH in the patient who underwent IGF-I therapy for >5 years: an auxological outcome similar to the one recently reported in the only two cases in the literature of patients with IGHD1A who have been treated with IGF-I until near FH achievement. We conclude that IGHD1A could have a very heterogeneous phenotypic expression in terms of FH and that IGF-I therapy, even though initiated some years before puberty onset and prolonged for more than 5 years, may not be able to ensure the normalization of height prognosis and the achievement of an FH close to TH.

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