scholarly journals Health Status, Mood, and Cognition in Experimentally Induced Subclinical Thyrotoxicosis

2008 ◽  
Vol 93 (5) ◽  
pp. 1730-1736 ◽  
Author(s):  
M. H. Samuels ◽  
K. G. Schuff ◽  
N. E. Carlson ◽  
P. Carello ◽  
J. S. Janowsky
Keyword(s):  
Mental Health ◽  
Working Memory ◽  
Health Status ◽  
Motor Learning ◽  
Physical Component Summary ◽  
Short Form ◽  
Free T3 ◽  
Sf 36 ◽  
Mood And Cognition ◽  
Subclinical Thyrotoxicosis

Abstract Objective: Our objective was to determine whether subclinical thyrotoxicosis alters health status, mood, and/or cognitive function. Design: This was a double-blinded, randomized, cross-over study of usual dose l-T4 (euthyroid arm) vs. higher dose l-T4 (subclinical thyrotoxicosis arm) in hypothyroid subjects. Patients: A total of 33 hypothyroid subjects receiving l-T4 were included in the study. Measurements: Subjects underwent measurements of health status, mood, and cognition: Short Form 36 (SF-36); Profile of Mood States (POMS); and tests of declarative memory (Paragraph Recall, Complex Figure), working memory (N-Back, Subject Ordered Pointing, and Digit Span Backwards), and motor learning (Pursuit Rotor). These were repeated after 12 wk on each of the study arms. Results: Mean TSH levels decreased from 2.15 to 0.17 mU/liter on the subclinical thyrotoxicosis arm (P < 0.0001), with normal mean free T4 and free T3 levels. The SF-36 physical component summary and general health subscale were slightly worse during the subclinical thyrotoxicosis arm, whereas the mental health subscale was marginally improved. The POMS confusion, depression, and tension subscales were improved during the subclinical thyrotoxicosis arm. Motor learning was better during the subclinical thyrotoxicosis arm, whereas declarative and working memory measures did not change. This improvement was related to changes in the SF-36 physical component summary and POMS tension subscales and free T3 levels. Conclusions: We found slightly impaired physical health status but improvements in measures of mental health and mood in l-T4 treated hypothyroid subjects when subclinical thyrotoxicosis was induced in a blinded, randomized fashion. Motor learning was also improved. These findings suggest that thyroid hormone directly affects brain areas responsible for affect and motor function.

scholarly journals Health Status, Mood, and Cognition in Experimentally Induced Subclinical Hypothyroidism

2007 ◽  
Vol 92 (7) ◽  
pp. 2545-2551 ◽  
Author(s):  
M. H. Samuels ◽  
K. G. Schuff ◽  
N. E. Carlson ◽  
P. Carello ◽  
J. S. Janowsky
Keyword(s):  
Working Memory ◽  
Health Status ◽  
Motor Learning ◽  
Subclinical Hypothyroidism ◽  
Declarative Memory ◽  
Short Form ◽  
Mood States ◽  
Profile Of Mood States ◽  
Free T4 ◽  
Mood And Cognition

Abstract Objective: The objective of the study was to determine whether subclinical hypothyroidism causes decrements in health status, mood, and/or cognitive function. Design: This was a double-blinded, randomized, crossover study of usual dose l-thyroxine (L-T4) (euthyroid arm) vs. lower dose L-T4 (subclinical hypothyroid arm) in hypothyroid subjects. Patients: Nineteen subjects on L-T4 therapy for primary hypothyroidism participated in the study. Measurements: Subjects underwent measurements of health status, mood, and cognition using validated instruments: Short Form 36, Profile of Mood States, and tests of declarative memory (paragraph recall, complex figure), working memory (N-back, subject ordered pointing, digit span backward), and motor learning (pursuit rotor). The same measures were repeated after 12 wk on each of the study arms. Results: Mean TSH levels increased to 17 mU/liter on the subclinical hypothyroid arm (P < 0.0001). Mean free T4 and free T3 levels remained within the normal range. The Profile of Mood States fatigue subscale and Short Form 36 general health subscale were slightly worse during the subclinical hypothyroid arm. Measures of working memory (N-back, subject ordered pointing) were worse during the subclinical hypothyroid arm. These differences did not depend on mood or health status but were related to changes in free T4 or free T3 levels. There were no decrements in declarative memory or motor learning. Conclusions: We found mild decrements in health status and mood in L-T4-treated hypothyroid subjects when subclinical hypothyroidism was induced in a blinded, randomized fashion. More importantly, there were independent decrements in working memory, which suggests that subclinical hypothyroidism specifically impacts brain areas responsible for working memory.

Preoperative Mental Health Score and Postoperative Outcome After Hallux Valgus Surgery

2018 ◽  
Vol 39 (12) ◽  
pp. 1403-1409 ◽  
Author(s):  
Sean Wei Hong Lai ◽  
Camelia Qian Ying Tang ◽  
Arjunan Edward Kumanan Graetz ◽  
Gowreeson Thevendran
Keyword(s):  
Mental Health ◽  
Health Status ◽  
Functional Outcome ◽  
Pain Score ◽  
Hallux Valgus ◽  
Short Form ◽  
Mental Health Status ◽  
Area Of Interest ◽  
Sf 36

Background: Preoperative mental health status as a predictor of operative outcome has been a growing area of interest. In this paper, the correlation between preoperative mental health status and postoperative functional outcome following scarf osteotomy for hallux valgus correction was explored. Methods: Parameters were tabulated preoperatively and postoperatively at a minimum of 1-year follow-up. They included the Short Form 36 (SF-36), American Orthopaedic Foot & Ankle Society (AOFAS) forefoot score, hallux valgus angle (HVA), and intermetatarsal angle (IMA) measurements and the visual analog score (VAS) to quantify pain. SF-36 mental component summary (MCS) score was used as a surrogate for patient’s mental health status. Seventy-six consecutive cases were analyzed at a minimum of 1-year follow-up. Results: There were significant improvements in all 8 domains of the SF-36, with the mean MCS score increasing from 52.3 ± 7.6 preoperatively to 55.7 ± 6.8 postoperatively. Preoperative MCS scores were not correlated to changes in AOFAS score, PCS score, VAS pain score, HVA or IMA. Preoperative MCS was observed to be correlated to postoperative AOFAS ( r = 0.381, P = .001) and PCS score ( r = 0.315, P = .006). Patients with a preoperative MCS score ⩾50 had a statistically higher postoperative AOFAS and PCS score than patients with MCS score <50. There was no correlation between preoperative MCS scores and improvements in radiologic parameters. There was also no correlation between the improvements in radiologic parameters and improvements in both the AOFAS and VAS pain scores. Conclusion: Preoperative mental health (as measured by the MCS score) was only correlated to postoperative functional outcome (as measured by the postoperative AOFAS and PCS score), but not other postoperative outcomes (VAS pain score, radiologic parameters). Level of Evidence: Level III, comparative study.

scholarly journals Aplicabilidade do questionário de qualidade de vida relacionada à saúde - the 12-Item Short-Form Health Survey - em pacientes portadores de esclerose sistêmica progressiva

2007 ◽  
Vol 33 (4) ◽  
pp. 414-422 ◽  
Author(s):  
Thamine Lessa Andrade ◽  
Aquiles Assunção Camelier ◽  
Fernanda Warken Rosa ◽  
Marcia Pina Santos ◽  
Sérgio Jezler ◽  
...  
Keyword(s):  
Health Survey ◽  
Physical Component Summary ◽  
Mental Component Summary ◽  
Short Form ◽  
Short Form Health Survey ◽  
Form Health ◽  
Sf 36 ◽  
Short Form Health

OBJETIVO: Avaliar a aplicabilidade do questionário 12-Item Short-Form Health Survey (SF-12) como instrumento de mensuração da qualidade de vida associada à saúde em uma amostra de pacientes com esclerose sistêmica progressiva (ESP) por meio da análise de sua reprodutibilidade e de sua correlação com parâmetros clínicos e funcionais. MÉTODOS: Estudo de reprodutibilidade, do tipo teste re-teste, para análise comparativa dos coeficientes de correlação intraclasse (CCI) dos questionários SF-12 e SF 36. Foram estudados 46 pacientes com diagnóstico de ESP, independentemente da presença de sintomas respiratórios. RESULTADOS: O escore do domínio físico do SF-12, conhecido como physical component summary 12 (PCS-12) em inglês, obteve um CCI de 0,47 (IC95%: 0,05-0,71; p < 0,02), enquanto o escore do domínio mental do SF-12, conhecido como mental component summary 12 (MCS-12) em inglês, obteve um CCI de 0,72 (IC95%: 0,49-0,84: p < 0,001). O escore do domínio físico do SF-36 (PCS-36) obteve um CCI de 0,88 (IC95%: 0,78-0,93; p < 0,001) e o escore do domínio mental do SF-36 (MCS-36) também obteve um CCI de 0,88 (IC95%: 0,78-0,93; p < 0,001). CONCLUSÃO: O questionário SF-12 é um instrumento confiável para medir a qualidade de vida em portadores de ESP pois demonstrou reprodutibilidade. Contudo, esta versão do SF-12 deve ser utilizada apenas em ambiente de pesquisa clínica.

Development and Testing of the UK SF-12

1997 ◽  
Vol 2 (1) ◽  
pp. 14-18 ◽  
Author(s):  
Crispin Jenkinson ◽  
Richard Layte
Keyword(s):  
Health Status ◽  
Short Form ◽  
Community Sample ◽  
Mental Component Summary Score ◽  
Well Being ◽  
Summary Score ◽  
Sf 36 ◽  
Patient Groups ◽  
The Uk ◽  
Component Scores

Objectives: The 36 item short form health survey (SF-36) has proved to be of use in a variety of settings where a short generic health measure of patient-assessed outcome is required. This measure can provide an eight dimension profile of health status, and two summary scores assessing physical function and mental well-being. The developers of the SF-36 in America have developed algorithms to yield the two summary component scores in a questionnaire containing only one-third of the original 36 items, the SF-12. This paper documents the construction of the UK SF-12 summary measures from a large-scale dataset from the UK in which the SF-36, together with other questions on health and lifestyles, was sent to randomly selected members of the population. Using these data we attempt here to replicate the findings of the SF-36 developers in the UK setting, and then to assess the use of SF-12 summary scores in a variety of clinical conditions. Methods: Factor analytical methods were used to derive the weights used to construct the physical and mental component scales from the SF-36. Regression methods were used to weight the 12 items recommended by the developers to construct the SF-12 physical and mental component scores. This analysis was undertaken on a large community sample ( n = 9332), and then the results of the SF-36 and SF-12 were compared across diverse patient groups (Parkinson's disease, congestive heart failure, sleep apnoea, benign prostatic hypertrophy). Results: Factor analysis of the SF-36 produced a two factor solution. The factor loadings were used to weight the physical component summary score (PCS-36) and mental component summary score (MCS-36). Results gained from the use of these measures were compared with results gained from the PCS-12 and MCS-12, and were found to be highly correlated (PCS: ρ = 0.94, p < 0.001; MCS: ρ = 0.96, p < 0.001), and produce remarkably similar results, both in the community sample and across a variety of patient groups. Conclusions: The SF-12 is able to produce the two summary scales originally developed from the SF-36 with considerable accuracy and yet with far less respondent burden. Consequently, the SF-12 may be an instrument of choice where a short generic measure providing summary information on physical and mental health status is required. Crispin Jenkinson DPhil, Deputy Director

scholarly journals From hospital to post-acute care organizations: the relationship between patient experience and health recovery

2020 ◽  
Vol 32 (9) ◽  
pp. 585-590
Author(s):  
Generosa Do Nascimento ◽  
Francisco Guilherme Nunes ◽  
Janet E Anderson
Keyword(s):  
Mental Health ◽  
Health Status ◽  
Acute Care ◽  
Patient Experience ◽  
Short Form ◽  
Mental Health Status ◽  
Patient Questionnaire ◽  
Discharge Process ◽  
Physical And Mental Health ◽  
Post Acute Care

Abstract Objective To determine to what extent patient health status and recovery in post-acute care organizations (PACO) is related to patient experience of the discharge process from hospital and to patient experience while staying in these facilities. Design Longitudinal study of patients discharged from hospitals to PACO. Setting 12 hospitals and 14 PACO Portuguese organizations. Participants 181 patients participated in the both stages of data gathering. Main Outcome Measures Patients’ physical and mental health status was measured through the 36-item short form health survey scale. The experience of transition from hospital to PACO was measured with the Care Transition Measure. The Picker Adult In-Patient Questionnaire was used to measure patients’ experience in these organizations. Results Patients reporting better physical condition in PACO had a better experience on discharge [b = 0.21, 95% confidence interval, CI (0.10, 0.31)] and perceive fewer problems inside facilities [b = − 0.19, 95% CI (−0.31, 0.08)]. The experience in PACO is significantly related to patients’ mental health status [b = − 0.47, 95% CI (−0.59, − 0.36)]. Patients showing higher levels of physical recovery had a better experience on discharge [b = − 0.18, 95% CI (0.08, 0.28)], while those registering better mental recovery experienced fewer problems during their stay [b = − 0.41, 95% CI (−0.52, − 0.30)]. Conclusions PACO play a key role in maintaining and promoting patients’ health, and this goal is influenced by their experience both in the transition from hospitals to PACO and while staying in these facilities.

The relationship of mental health status to functional outcome and satisfaction after carpal tunnel release

2019 ◽  
Vol 45 (2) ◽  
pp. 147-152 ◽  
Author(s):  
Julian F. Maempel ◽  
Paul J. Jenkins ◽  
Jane E. McEachan
Keyword(s):  
Mental Health ◽  
Health Status ◽  
Carpal Tunnel ◽  
Mental Component Summary ◽  
Short Form ◽  
Carpal Tunnel Release ◽  
Mental Health Status ◽  
Mental Disability ◽  
Level Of Evidence ◽  
Patient Reported

We studied whether mental health status is significantly correlated to patient reported functional outcomes and satisfaction after carpal tunnel release. Over a 7-year period, 809 patients completed Short Form-12 (SF-12) questionnaires which allowed calculation of the SF-12 mental component summary 1 year postoperatively, 780 (96%) completed a satisfaction questionnaire and 777 (96%) completed a QuickDisabilities of the Arm, Shoulder, and Hand (DASH) questionnaire. Median QuickDASH score was 55 preoperatively (interquartile range [IQR] 28) and 14 postoperatively (IQR 32). A total of 674 patients were satisfied. Patients with mental disability had worse QuickDASH scores (median 34, IQR 41) and a higher incidence of dissatisfaction (52/245, 21%) than those without mental disability (n = 9, IQR 20, 10%, both p < 0.001). Regression analyses indicated scores in the SF-12 mental component summary were significantly related to postoperative QuickDASH score ( p < 0.001) and satisfaction ( p = 0.02). We concluded that patients with mental disability report poorer outcomes and lower satisfaction rates; however, the majority still exhibit significant improvements and are satisfied. Level of evidence: II

scholarly journals Assessing Depression among Older Persons with Arthritis: A Nationwide Health Status Survey

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Rajesh Nayak ◽  
Jigar Rajpura
Keyword(s):  
Health Status ◽  
Older Persons ◽  
Depressive Symptomatology ◽  
Short Form ◽  
Depressive Mood ◽  
Care Practice ◽  
Elderly Persons ◽  
Early Screening ◽  
Sf 36 ◽  
Nationally Representative

Objectives. This study aimed to assess the health status of a nationwide sample of elderly persons having arthritis and determine the prevalence of depressive symptomatology in this population. Methods. WebTV technology was utilized to administer health status and depression surveys to a nationally representative sample of 550 randomly selected older persons. Predetermined cutoff scores on Short Form-36 (SF-36) scale and Center for Epidemiological Scale for Depression (CES-D) were used to identify individuals with depressive mood. Results. Sixteen percent () of the respondents were found to be at risk for depression. Key associations among health domains of SF-36 and CES-D variables were statistically significant and were in the expected direction. Discussion. The risk of depression among older adults who have arthritis is moderate. A significant decline in multiple domains of health of older persons is likely when depression coexists with arthritis. Early screening for depressive symptomatology and prompt treatment should be an essential part of arthritis management in primary care practice.

scholarly journals The impact of smoking cessation on patient quality of life

2009 ◽  
Vol 35 (5) ◽  
pp. 436-441 ◽  
Author(s):  
Maria Penha Uchoa Sales ◽  
Maria Irenilza Oliveira ◽  
Isabela Melo Mattos ◽  
Cyntia Maria Sampaio Viana ◽  
Eanes Delgado Barros Pereira
Keyword(s):  
Quality Of Life ◽  
Mental Health ◽  
Smoking Cessation ◽  
Short Form ◽  
Analysis Of Covariance ◽  
Sf 36 ◽  
Related Quality ◽  
A Prospective Study ◽  
The Impact

OBJECTIVE: To evaluate changes in health-related quality of life (HRQoL) after twelve months of smoking cessation. METHODS: This was a prospective study to evaluate the effectiveness of a smoking cessation program on the quality of life of 60 self-referred subjects, at a public hospital, during the period of August 2006 to December 2007. The program consisted of 2-h group sessions once a week during the first month and then every 15 days over six months, followed by monthly phone contacts for another six months. The treatment was based on behavior modification and the use of bupropion in combination with nicotinic replacement therapy. Abstinence was verified by exhaled CO measurements. Patient HRQoL was quantified using the Medical Outcomes Study 36-item Short-Form Health Survey (SF-36) questionnaire. Differences in quality of life scores between quitters and non-quitters at twelve months after the initial intervention were evaluated using analysis of covariance with baseline characteristics as covariates. RESULTS: Self-reported quality of life scores were significantly higher among the 40 quitters than among the 20 non-quitters. The following SF-36 domains were most affected: role-emotional (p = 0.008); general health (p = 0.006); vitality (p < 0.001); and mental health (p = 0.002). At twelve months after the smoking cessation intervention, the SF-36 mental component and physical component summary scores were higher among quitters than among non-quitters (p = 0.004 and p = 0.001, respectively). CONCLUSIONS: Our findings illustrate that smoking abstinence is related to better HRQoL, especially in aspects of mental health.

scholarly journals Improved pain, physical functioning and health status in patients with rheumatoid arthritis treated with CP-690,550, an orally active Janus kinase (JAK) inhibitor: results from a randomised, double-blind, placebo-controlled trial

2009 ◽  
Vol 69 (2) ◽  
pp. 413-416 ◽  
Author(s):  
J H Coombs ◽  
B J Bloom ◽  
F C Breedveld ◽  
M P Fletcher ◽  
D Gruben ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Health Status ◽  
Short Form ◽  
Controlled Trial ◽  
Health Assessment ◽  
Janus Kinase ◽  
Inadequate Response ◽  
Double Blind ◽  
Sf 36 ◽  
Factor Α

Objectives:To determine the efficacy of CP-690,550 in improving pain, function and health status in patients with moderate to severe active rheumatoid arthritis (RA) and an inadequate response to methotrexate or a tumour necrosis factor α inhibitor.Methods:Patients were randomised equally to placebo, CP-690,550 5, 15 or 30 mg twice daily for 6 weeks, with 6 weeks’ follow-up. The patient’s assessment of arthritis pain (pain), patient’s assessment of disease activity, Health Assessment Questionnaire-Disability Index (HAQ-DI) and Short Form-36 (SF-36) were recorded.Results:At week 6, significantly more patients in the CP-690,550 5, 15 and 30 mg twice-daily groups experienced a 50% improvement in pain compared with placebo (44%, 66%, 78% and 14%, respectively), clinically meaningful reductions in HAQ-DI (⩾0.3 units) (57%, 75%, 76% and 36%, respectively) and clinically meaningful improvements in SF-36 domains and physical and mental components.Conclusions:CP-690,550 was efficacious in improving the pain, function and health status of patients with RA, from week 1 to week 6.

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