scholarly journals Efficacy and Safety of Strontium Ranelate in the Treatment of Osteoporosis in Men

2013 ◽  
Vol 98 (2) ◽  
pp. 592-601 ◽  
Author(s):  
J.-M. Kaufman ◽  
M. Audran ◽  
G. Bianchi ◽  
V. Braga ◽  
M. Diaz-Curiel ◽  
...  
Keyword(s):  
Strontium Ranelate ◽  
Efficacy And Safety ◽  
Treatment Of Osteoporosis ◽  
Osteoporosis In Men

scholarly journals Could Strontium Ranelate Have a Synergistic Role in the Treatment of Osteoporosis?

2009 ◽  
Vol 24 (8) ◽  
pp. 1354-1357 ◽  
Author(s):  
Glen M Blake ◽  
Juliet E Compston ◽  
Ignac Fogelman
Keyword(s):  
Strontium Ranelate ◽  
Treatment Of Osteoporosis

New Therapies for Osteoporosis

2008 ◽  
Vol 22 (1) ◽  
pp. 53-64
Author(s):  
Karly A. Hegge ◽  
Anisa S. Fornoff ◽  
Sheryl L. Gutierres ◽  
Sally L. Haack
Keyword(s):  
Therapeutic Option ◽  
Sequential Therapy ◽  
The United States ◽  
Health Concern ◽  
Treatment Of Osteoporosis ◽  
Estrogen Receptor Modulators ◽  
Osteoporosis In Men ◽  
Surrogate Measures ◽  
Receptor Modulators

Osteoporosis is a growing health concern in the United States, with an enormous impact on morbidity and mortality. Despite published guidelines to aid clinicians in its management, several controversies remain. Many trials evaluate surrogate measures of bone strength rather than more clinically relevant outcomes, including fracture. Furthermore, the role of combination and sequential therapy remains unclear. Limited data are available regarding appropriate duration of therapy, management of osteoporosis in men, and treatment of glucocorticoid-induced osteoporosis. The development of unique therapeutic agents could potentially revolutionize the treatment of osteoporosis. Once yearly zoledronic acid may provide advantages over existing therapies. Because of limitations with existing selective estrogen receptor modulators, the search for agents with better efficacy and safety profiles has led to the development of several new medications within this class. Finally, denosumab, a monoclonal antibody to receptor activator for nuclear factor-kappa B ligand, also represents a novel therapeutic option for osteoporosis.

scholarly journals Elemental Mapping Of Bone Strontium In Rats Treated With Strontium Ranelate And Strontium Citrate Using 2D Micro-XRF And 3D Dual Energy K-edge Subtraction X-ray Imaging

2021 ◽  
Author(s):  
Daniel Arturo Cardenas
Keyword(s):  
Strontium Ranelate ◽  
Dual Energy ◽  
Therapeutic Effects ◽  
Sprague Dawley ◽  
Treatment Of Osteoporosis ◽  
3D Images ◽  
X Ray ◽  
X Ray Imaging ◽  
Sprague Dawley Rats ◽  
Animal Bones

Strontium-based medications, such as strontium ranelate, have been shown to have therapeutic effects in the treatment of osteoporosis, other strontium salts are assumed to have similar effects on bone health. The objective of this study was to compare the distribution of strontium in animal bones following administration of strontium ranelate and strontium citrate. Humerus bones were collected from female Sprague-Dawley rats that were dosed daily over ten weeks with strontium ranelate and strontium citrate, and no strontium (control). Bones were imaged using 2D micro-XRF and 3D dual energy KES X-ray imaging. The 2D imaging revealed differences in strontium and calcium levels between samples from treated and non-treated animals (푝 < 0.001). 3D images obtained showed that strontium was observed to be largely present in the trabecular regions under the epiphyseal plate with concentrations of approximately 5 to 15 mg/cm3 in the bones of both strontium treated groups. The thickness of the strontium layers below the growth plate in both the strontium ranelate and strontium citrate sample were not significantly different (푝 = 0.9201). Both imaging studies performed in this work showed that strontium from both salts is heterogeneously distributed in newly formed bone during treatment.

Efficacy and safety of 2 g/day of strontium ranelate in Asian women with postmenopausal osteoporosis

Bone ◽  
2009 ◽  
Vol 45 (3) ◽  
pp. 460-465 ◽  
Author(s):  
Jian-Min Liu ◽  
Annie Wai-chee Kung ◽  
Chan Siew Pheng ◽  
Han-Min Zhu ◽  
Zhen-Lin Zhang ◽  
...  
Keyword(s):  
Postmenopausal Osteoporosis ◽  
Strontium Ranelate ◽  
Asian Women ◽  
Efficacy And Safety

Efficacy and safety of oral strontium ranelate for the treatment of knee osteoarthritis: rationale and design of randomised, double-blind, placebo-controlled trial

2012 ◽  
Vol 28 (2) ◽  
pp. 231-239 ◽  
Author(s):  
Cyrus Cooper ◽  
Jean-Yves Reginster ◽  
Roland Chapurlat ◽  
Claus Christiansen ◽  
Harry Genant ◽  
...  
Keyword(s):  
Knee Osteoarthritis ◽  
Strontium Ranelate ◽  
Controlled Trial ◽  
Efficacy And Safety ◽  
Double Blind ◽  
Double Blind Placebo

Alendronate for the Treatment of Osteoporosis in Men

2000 ◽  
Vol 343 (9) ◽  
pp. 604-610 ◽  
Author(s):  
Eric Orwoll ◽  
Mark Ettinger ◽  
Stuart Weiss ◽  
Paul Miller ◽  
David Kendler ◽  
...  
Keyword(s):  
Treatment Of Osteoporosis ◽  
Osteoporosis In Men
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