Sex steroid modulation of neurohypophysial hormone receptors in human nonpregnant myometrium

Approximately 1 million people in the United States alone develop gallstones each year. The incidence is higher in women than in men and the ratio being 4 ≥ 1. A correlation has also been suggested between oral contraceptives and cholelithiasis. In addition, postmenopausal or cancer estrogen therapy has been reported to be a factor responsible for gallstone formation. Female sex hormone receptors have been detected not only in the gallbladder musculature, but also in its epithelium. As a follow up to experiments effectuated in the male and the ovariectomized Syrian hamster, this report shows that, a combination of a low cholesterol diet with female sex steroid treatment contributes to the formation of gallstone-like deposits, while modifying the surface epithelium morphology. Syrian hamsters (F1B strain, BioBreeders, Watertown MA) were housed under 12h light: 12 h dark cycle, at 20 °C, fed Purina chow and water ad libitum. Several duration/treatment groups were studied, but this report will focus on data obtained with the group injected weekly with estradiol valerate (E weekly, s.c. 8-10 μg/100 g.b.w., in corn oil) and with i.m. medroxyprogesterone acetate (DepoProvera Upjohn Co., Kalamazoo, MI; 8-10 mg/100 g.b.w.) for a 3-month period. Other parameters (blood and bile) were also studied but not reported here.

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Pelvic floor sex steroid hormone receptors, distribution and expression in pre- and postmenopausal stress urinary incontinent women

Acta Obstetricia Et Gynecologica Scandinavica ◽

10.1080/00016340701625446 ◽

2007 ◽

Vol 86 (11) ◽

pp. 1377-1384 ◽

Cited By ~ 26

Author(s):

Marie Westergren Söderberg ◽

Bengt Johansson ◽

Britt Masironi ◽

Birgitta Byström ◽

Christian Falconer ◽

...

Keyword(s):

Pelvic Floor ◽

Hormone Receptors ◽

Steroid Hormone ◽

Steroid Hormone Receptors ◽

Sex Steroid ◽

Sex Steroid Hormone

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Immunolocalization of sex steroid hormone receptors in the canine uterine tube and their relation to sex steroid hormone levels

Reproduction Fertility and Development ◽

10.1071/rd01084 ◽

2002 ◽

Vol 14 (4) ◽

pp. 241 ◽

Cited By ~ 9

Author(s):

Hilde Vermeirsch ◽

Wim Van Den Broeck ◽

Mark Coryn ◽

Paul Simoens

Keyword(s):

Epithelial Cells ◽

Estrous Cycle ◽

Stromal Cells ◽

Hormone Receptors ◽

Steroid Hormone ◽

Steroid Hormone Receptors ◽

Sex Steroid ◽

Nuclear Staining ◽

Sex Steroid Hormone ◽

Uterine Tube

The aim of this immunohistochemical study was to describe the cellular distribution of the estrogen receptor-α (ERα), progesterone receptor (PR) and androgen receptor (AR) in canine uterine tubes. Samples of uterine tubes were taken from dogs in different stages of the estrous cycle, and dogs that were pregnant or had just delivered. Nuclear staining for sex steroid hormone receptors was observed in the surface epithelium, stromal cells and smooth muscle cells of the muscular layer. Only slight differences in staining pattern were observed between the ampulla and fimbriae. The staining for ERα and PR showed changes throughout the estrous cycle. Some of these changes were related to changing concentrations of sex steroid hormones. High staining scores for ERα and PR were found during proestrus and low scores during early metestrus. The staining for AR showed only minor cyclic changes. However, during proestrus and estrus, cytoplasmic staining for AR was observed in differentiated secretory epithelial cells, when nuclear staining in these cells was nearly absent. For the three hormone receptors, stromal cells generally stained with a higher intensity than epithelial cells. It is likely that many steroid hormone actions on the epithelium are mediated through stromal cells. During pregnancy, rather high staining scores were found for ERα and AR in the uterine tube. This is in contrast to observations in the canine pregnant uterus.

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