Stimulation of primate luteal function by recombinant human chorionic gonadotropin and modulation of steroid, but not relaxin, production by an inhibitor of 3 beta-hydroxysteroid dehydrogenase during simulated early pregnancy

1996 ◽  
Vol 81 (6) ◽  
pp. 2307-2313 ◽  
Author(s):  
D. M. Duffy
Keyword(s):  
Chorionic Gonadotropin ◽  
Early Pregnancy ◽  
Human Chorionic Gonadotropin ◽  
Hydroxysteroid Dehydrogenase ◽  
Luteal Function ◽  
Stimulation Of

scholarly journals Dynamic Changes in Mitogen-Activated Protein Kinase (MAPK) Activities in the Corpus Luteum of the Bonnet Monkey (Macaca radiata) during Development, Induced Luteolysis, and Simulated Early Pregnancy: A Role for p38 MAPK in the Regulation of Luteal Function

Endocrinology ◽  
2006 ◽  
Vol 147 (4) ◽  
pp. 2018-2027 ◽  
Author(s):  
V. K. Yadav ◽  
R. Medhamurthy
Keyword(s):  
Protein Kinase ◽  
Chorionic Gonadotropin ◽  
Early Pregnancy ◽  
Human Chorionic Gonadotropin ◽  
Luteal Phase ◽  
Caspase 3 ◽  
Luteal Function ◽  
Mapk Kinase ◽  
Late Luteal Phase ◽  
Bonnet Monkey

Changes in MAPK activities were examined in the corpus luteum (CL) during luteolysis and pregnancy, employing GnRH antagonist (Cetrorelix)-induced luteolysis, stages of CL, and hCG treatment to mimic early pregnancy as model systems in the bonnet monkey. We hypothesized that MAPKs could serve to phosphorylate critical phosphoproteins to regulate luteal function. Analysis of several indices for structural (caspase-3 activity and DNA fragmentation) and functional (progesterone and steroidogenic acute regulatory protein expression) changes in the CL revealed that the decreased luteal function observed during Cetrorelix treatment and late luteal phase was associated with increased caspase-3 activity and DNA fragmentation. As expected, human chorionic gonadotropin treatment dramatically increased luteal function, but the indices for structural changes were only partially attenuated. All three MAPKs appeared to be constitutively active in the mid-luteal-phase CL, and activities of ERK-1/2 and p38-MAPK (p38), but not Jun N-terminal kinase (JNK)-1/2, decreased significantly (P < 0.05) within 12–24 h after Cetrorelix treatment. During the late luteal phase, in contrast to decreased ERK-1/2 and p38 activities, JNK-1/2 activities increased significantly (P < 0.05). Although human chorionic gonadotropin treatment increased ERK-1/2 and p38 activities, it decreased JNK-1/2 activities. The activation status of p38 was correlated with the phosphorylation status of an upstream activator, MAPK kinase-3/6 and the expression of MAPK activated protein kinase-3, a downstream target. Intraluteal administration of p38 kinase inhibitor (SB203580), but not MAPK kinase-1/2 inhibitor (PD98059), decreased the luteal function. Together, these data suggest an important role for p38 in the regulation of CL function in primates.

Pregnancy and obstetric complications in women with autoimmune diseases

2021 ◽  
pp. 125-142
Author(s):  
D. Ware Branch
Keyword(s):  
Menstrual Cycle ◽  
Autoimmune Diseases ◽  
Chorionic Gonadotropin ◽  
Early Pregnancy ◽  
Human Chorionic Gonadotropin ◽  
Normal Pregnancy ◽  
Obstetric Complications ◽  
Optimal Management ◽  
Foetal Development ◽  
Rheumatic Conditions

For most women, pregnancy is suspected when the symptoms of early pregnancy develop—these include breast soreness or tenderness, fatigue, nausea, and missed menses. Human chorionic gonadotropin (hCG) is first detectable using sensitive tests in the urine and blood of pregnant women 8–10 days after conception (day 22–24 of a 28-day menstrual cycle). Concentrations of hCG rise rapidly in early pregnancy, peak at 9–10 weeks, and decline thereafter to a nadir at 20 weeks. Understanding embryo-foetal development and maternal physiological accommodation to pregnancy is required for the optimal management of pregnancy in women with autoimmune diseases. This chapter reviews the important developmental and physiologic aspects of normal pregnancy and both common and unique obstetric complications associated with selected rheumatic conditions.

Human Chorionic Gonadotropin and the Diagnosis of Early Pregnancy

2010 ◽  
pp. 426-428
Author(s):  
Rene B. Allen ◽  
Mario J. Pineda ◽  
Frank Z. Stanczyk ◽  
Richard J. Paulson
Keyword(s):  
Chorionic Gonadotropin ◽  
Early Pregnancy ◽  
Human Chorionic Gonadotropin

Trophectoderm biopsy reduces the level of serum β-human chorionic gonadotropin in early pregnancy

2020 ◽  
Vol 114 (4) ◽  
pp. 801-808 ◽  
Author(s):  
Man-man Lu ◽  
Yang-xing Wen ◽  
Yu-liang Liu ◽  
Chen-hui Ding ◽  
Can-quan Zhou ◽  
...  
Keyword(s):  
Chorionic Gonadotropin ◽  
Early Pregnancy ◽  
Human Chorionic Gonadotropin ◽  
Trophectoderm Biopsy
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