Impaired Modulation of Hepatic Glucose Output Overnight after a 72-h Fast in Normal Man*

1990 ◽  
Vol 70 (4) ◽  
pp. 865-868 ◽  
Author(s):  
J. N. CLORE ◽  
S. T. HELM ◽  
J. E. NESTLER ◽  
W. G. BLACKARD
Keyword(s):  
Hepatic Glucose Output ◽  
Hepatic Glucose ◽  
Normal Man ◽  
Glucose Output

Effects of oxytocin upon the endocrine pancreas secretion and glucose turnover in normal man

1990 ◽  
Vol 123 (5) ◽  
pp. 504-510 ◽  
Author(s):  
Giuseppe Paolisso ◽  
Gennaro Pizza ◽  
Stefano De Riu ◽  
Giuseppe Marrazzo ◽  
Saverio Sgambato ◽  
...  
Keyword(s):  
Plasma Glucose ◽  
Glucose Infusion ◽  
Glucose Turnover ◽  
Metabolic Clearance ◽  
Hepatic Glucose Output ◽  
Glucose Levels ◽  
Glucose Disappearance ◽  
Hepatic Glucose ◽  
Normal Man ◽  
Glucose Output

Abstract. In normal man oxytocin infusion under basal conditions and at pharmacological doses evoked a rapid surge in plasma glucose and glucagon levels followed by a later increase in plasma insulin levels. Simultaneous [D-3H]glucose infusion indicated that oxytocin also produced a prompt and significant increase in hepatic glucose output with a secondary increase in glucose disappearance rate. Eight healthy volunteers were studied during euglycemic glucose clamp and simultaneous [D-3H]glucose infusion, during suppression of endogenous pancreatic secretion by cyclic somatostatin (250 μg/h) and during exogenous glucagon (67 ng/min) and insulin (0.15 mU · kg−1 · min−1 from 0 to 120 min and 0.40 mU · kg−1 · min−1 from 121 to 240 min) replacement. During the first 60 min oxytocin (0.2 U/min) evoked a transient but significant increase in plasma glucose levels and hepatic glucose output with a simultaneous suppression of the glucose infusion rate. No difference in glucose disappearance and metabolic clearance rates were recorded throughout the clamp irrespective of whether oxytocin was infused or not. So we conclude that oxytocin exerts a hyperglycemic effect through an A-cell stimulation and a glycogenolytic action.

Evidence for dual control mechanism regulating hepatic glucose output in nondiabetic men

Diabetes ◽  
1991 ◽  
Vol 40 (8) ◽  
pp. 1033-1040 ◽  
Author(s):  
J. N. Clore ◽  
P. S. Glickman ◽  
S. T. Helm ◽  
J. E. Nestler ◽  
W. G. Blackard
Keyword(s):  
Control Mechanism ◽  
Dual Control ◽  
Hepatic Glucose Output ◽  
Hepatic Glucose ◽  
Glucose Output

Role of hyperglucagonemia in maintenance of increased rates of hepatic glucose output in type II diabetics

Diabetes ◽  
1987 ◽  
Vol 36 (3) ◽  
pp. 274-283 ◽  
Author(s):  
A. D. Baron ◽  
L. Schaeffer ◽  
P. Shragg ◽  
O. G. Kolterman
Keyword(s):  
Type Ii ◽  
Hepatic Glucose Output ◽  
Hepatic Glucose ◽  
Type Ii Diabetics ◽  
Glucose Output

Free fatty acid as a link in the regulation of hepatic glucose output by peripheral insulin

Diabetes ◽  
1995 ◽  
Vol 44 (9) ◽  
pp. 1038-1045 ◽  
Author(s):  
K. Rebrin ◽  
G. M. Steil ◽  
L. Getty ◽  
R. N. Bergman
Keyword(s):  
Fatty Acid ◽  
Free Fatty Acid ◽  
Hepatic Glucose Output ◽  
Hepatic Glucose ◽  
Glucose Output
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