Effect of Treatment with Biosynthetic Human Growth Hormone (GH) on Peripheral Blood Lymphocyte Populations and Function in Growth Hormone-Deficient Children

1990 ◽  
Vol 70 (6) ◽  
pp. 1756-1760 ◽  
Author(s):  
BRUCE H. PETERSEN ◽  
ROBERT RAPAPORT ◽  
DAVID P. HENRY ◽  
CAROL HUSEMAN ◽  
WAYNE V. MOORE
Keyword(s):  
Growth Hormone ◽  
Human Growth Hormone ◽  
Peripheral Blood Lymphocyte ◽  
Peripheral Blood ◽  
Blood Lymphocyte ◽  
Human Growth ◽  
Effect Of Treatment ◽  
And Function ◽  
Lymphocyte Populations

scholarly journals Peripheral blood lymphocyte counts during standard conformal radiotherapy and TomoTherapy/IMRT for prostate cancer

2008 ◽  
Vol 7 (4) ◽  
pp. 223-227 ◽  
Author(s):  
M. Elsworthy ◽  
P.N. Plowman
Keyword(s):  
Peripheral Blood Lymphocyte ◽  
Peripheral Blood ◽  
Blood Lymphocyte ◽  
Small Volume ◽  
Intensity Modulated Radiation Therapy ◽  
Conformal Radiotherapy ◽  
Peripheral Lymphocyte ◽  
Prostate Radiotherapy ◽  
The Mean ◽  
Lymphocyte Populations

AbstractLymphopaenia is the earliest and the most sensitive routinely assessed biological parameter of corporeal radiation exposure in clinical practice; bone marrow, lymph nodes and peripheral blood lymphocyte populations are also at risk. During radical prostate radiotherapy, in 28 patients, the mean peripheral lymphocyte count fell from 1.76 × 109/l (standard deviation (SD) 0.63, 95% confidence interval (conf.) 0.23) to 1.10 × 109/l (SD 0.38, conf. 0.14), (p < 0.05). The question was asked as to whether intensity-modulated radiation therapy (IMRT) by TomoTherapy would cause more lymphopaenia than three-field conformal radiotherapy, bearing in mind the ‘low dose bath’ effect of IMRT and the long ‘beam-on’ times. Thirteen patients receiving three-field conformal radiotherapy experienced a fall in peripheral lymphocyte counts from 2.02 (SD: 0.62. conf. 0.43) to 1.17 × 109/l (SD: 0.47, conf. 0.26) after 34–38 Gy, as compared to a fall from 1.6 × 109/l (SD: 0.6, conf. 0.35) to 1.04 × 109/l (SD: 0.3, conf. 0.15) for 15 TomoTherapy patients—non-significant differences. We conclude that for this (approximately) standard, small-volume pelvic radiotherapy and to the dose under scrutiny, we cannot detect differences between the two radiotherapy techniques in terms of the lymphopaenia accruing. Neutrophil counts were similarly non-significantly different.

Placental Expression and Function of the Human Growth Hormone Gene Cluster

1993 ◽  
pp. 222-239 ◽  
Author(s):  
N. E. Cooke ◽  
B. K. Jones ◽  
M. Urbanek ◽  
A. Misra-Press ◽  
A. K. Lee ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Gene Cluster ◽  
Human Growth Hormone ◽  
Human Growth ◽  
Growth Hormone Gene ◽  
And Function ◽  
Human Growth Hormone Gene
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