Visceral fat accumulation in relation to sex hormones in obese men and women undergoing weight loss therapy.

Seventy-eight healthy obese subjects, 40 premenopausal women and 38 men aged 27-51 yr received a 4.2 MJ/day energy-deficit diet for 13 wk. Resting metabolic rate (RMR) and diet-induced thermogenesis (DIT) were measured by indirect calorimetry. Abdominal subcutaneous and visceral fat areas were calculated from magnetic resonance imaging scans before and after weight loss. Before weight loss, visceral fat accumulation was positively correlated with higher levels of RMR (P < 0.05) and DIT (P < 0.01) in women but not in men. The mean weight reduction was 12.2 +/- 3.5 (SD) kg. In men but not in women, an initially large visceral fat depot was associated with a reduced loss of weight and total fat mass (P < 0.05). Within each sex, an initial abundance of visceral fat was significantly related to a larger loss of visceral fat (P < 0.001) and in men to a smaller loss of subcutaneous fat (P < 0.05). These results suggest that there may be gender differences in the associations between visceral fat accumulation and components of energy expenditure (RMR and DIT) in obese subjects. Obese subjects with an initial abundance of visceral fat do not lose more body weight but more visceral fat than subjects with less visceral fat.

Download Full-text

Visceral Fat Accumulation Is an Important Determinant of PAI-1 Levels in Young, Nonobese Men and Women

Arteriosclerosis Thrombosis and Vascular Biology ◽

10.1161/01.atv.18.11.1716 ◽

1998 ◽

Vol 18 (11) ◽

pp. 1716-1722 ◽

Cited By ~ 63

Author(s):

E. J. Giltay ◽

J. M. H. Elbers ◽

L. J. G. Gooren ◽

J. J. Emeis ◽

T. Kooistra ◽

...

Keyword(s):

Visceral Fat ◽

Important Determinant ◽

Men And Women ◽

Fat Accumulation ◽

Visceral Fat Accumulation ◽

Pai 1

Download Full-text

Visceral fat accumulation measured by magnetic resonance imaging in relation to serum lipids in obese men and women

Atherosclerosis ◽

10.1016/0021-9150(92)90242-9 ◽

1992 ◽

Vol 94 (2-3) ◽

pp. 171-181 ◽

Cited By ~ 45

Author(s):

Rianne Leenen ◽

Karin van der Kooy ◽

Jaap C. Seidell ◽

Paul Deurenberg

Keyword(s):

Magnetic Resonance Imaging ◽

Magnetic Resonance ◽

Visceral Fat ◽

Serum Lipids ◽

Resonance Imaging ◽

Men And Women ◽

Fat Accumulation ◽

Visceral Fat Accumulation

Download Full-text

Effects of Visceral Fat Accumulation Awareness on a Web-Based Weight-Loss Program: Japanese Study of Visceral Adiposity and Lifestyle Information—Utilization and Evaluation (J-VALUE)

ISRN Obesity ◽

10.1155/2013/473764 ◽

2013 ◽

Vol 2013 ◽

pp. 1-7 ◽

Cited By ~ 3

Author(s):

Naoki Sakane ◽

Seitaro Dohi ◽

Koichi Sakata ◽

Shin-ichi Hagiwara ◽

Toshihisa Morimoto ◽

...

Keyword(s):

Weight Loss ◽

Visceral Fat ◽

Weight Loss Program ◽

Control Group ◽

Self Awareness ◽

Hospital Organization ◽

Web Based ◽

Fat Accumulation ◽

Healthy Behaviors ◽

Visceral Fat Accumulation

A reduction of visceral fat is important for improvement of metabolic risk. This study was designed to compare the effects of a web-based program alone or together with measurement and self-awareness of accumulated visceral fat in Japanese workers. A new noninvasive device to measure visceral fat accumulation was introduced, and efficacy on weight-loss and improvement of healthy behaviors were examined. This study was conducted according to Helsinki declaration and approved by the ethical committee of Japan Hospital Organization, National Kyoto Hospital. Two-hundred and sixteen overweight and obese males with BMI of more than 23 participated from 8 healthcare offices of 3 Japanese private companies. Subjects were randomly allocated into control group, Web-based weight-loss program (Web), or Web + Visceral fat measurement group (Web + VFA). Eighty-one percent of participants completed the study. Reductions of body weight, waist circumference, and BMI were the largest in Web + VFA group, and the differences between groups were significant by ANOVA. Improvements of healthy behaviors were the largest in Web + VFA group, and the differences of healthy eating improvement scores between Web + VFA and control groups were significant. Our findings suggest that measurement and awareness of visceral fat are effective in weight reduction in overweight and obese males in the workplace.

Download Full-text

Potent anti-obesity effect of enteric-coated lactoferrin: decrease in visceral fat accumulation in Japanese men and women with abdominal obesity after 8-week administration of enteric-coated lactoferrin tablets – CORRIGENDUM

British Journal Of Nutrition ◽

10.1017/s0007114515001853 ◽

2015 ◽

Vol 114 (1) ◽

pp. 159-159 ◽

Cited By ~ 1

Author(s):

Tomoji Ono ◽

Michiaki Murakoshi ◽

Noriyuki Suzuki ◽

Norio Iida ◽

Motoyasu Ohdera ◽

...

Keyword(s):

Abdominal Obesity ◽

Visceral Fat ◽

Japanese Men ◽

Men And Women ◽

Fat Accumulation ◽

Visceral Fat Accumulation ◽

Enteric Coated

Download Full-text

Potent anti-obesity effect of enteric-coated lactoferrin: decrease in visceral fat accumulation in Japanese men and women with abdominal obesity after 8-week administration of enteric-coated lactoferrin tablets

British Journal Of Nutrition ◽

10.1017/s0007114510002734 ◽

2010 ◽

Vol 104 (11) ◽

pp. 1688-1695 ◽

Cited By ~ 59

Author(s):

Tomoji Ono ◽

Michiaki Murakoshi ◽

Noriyuki Suzuki ◽

Norio Iida ◽

Motoyasu Ohdera ◽

...

Keyword(s):

Abdominal Obesity ◽

Visceral Fat ◽

Subcutaneous Fat ◽

Japanese Men ◽

Men And Women ◽

Fat Accumulation ◽

Visceral Fat Accumulation ◽

The Metabolic Syndrome ◽

Computed Tomography Images ◽

Enteric Coated

Lactoferrin (LF), a multifunctional glycoprotein in mammalian milk, is reported to exert a modulatory effect on lipid metabolism. The aim of the present study was to elucidate whether enteric-coated LF (eLF) might improve visceral fat-type obesity, an underlying cause of the metabolic syndrome. Using a double-blind, placebo-controlled design, Japanese men and women (n26; aged 22–60 years) with abdominal obesity (BMI>25 kg/m2, and visceral fat area (VFA)>100 cm2) consumed eLF (300 mg/d as bovine LF) or placebo tablets for 8 weeks. Measurement of the total fat area, VFA and subcutaneous fat area from computed tomography images revealed a significant reduction in VFA ( − 14·6 cm2) in the eLF group, as compared with the placebo controls ( − 1·8 cm2;P = 0·009 by ANCOVA). Decreases in body weight, BMI and hip circumference in the eLF group ( − 1·5 kg, − 0·6 kg/m2, − 2·6 cm) were also found to be significantly greater than with the placebo (+1·0 kg, +0·3 kg/m2, − 0·2 cm;P = 0·032, 0·013, 0·041, respectively). There was also a tendency for a reduction in waist circumference in the eLF group ( − 4·4 cm) as compared with the placebo group ( − 0·9 cm;P = 0·073). No adverse effects of the eLF treatment were found with regard to blood lipid or biochemical parameters. From these results, eLF appears to be a promising agent for the control of visceral fat accumulation.

Download Full-text