Visceral fat accumulation in obese subjects: relation to energy expenditure and response to weight loss

1992 ◽  
Vol 263 (5) ◽  
pp. E913-E919 ◽  
Author(s):  
R. Leenen ◽  
K. van der Kooy ◽  
P. Deurenberg ◽  
J. C. Seidell ◽  
J. A. Weststrate ◽  
...  
Keyword(s):  
Weight Loss ◽  
Energy Expenditure ◽  
Visceral Fat ◽  
Resting Metabolic Rate ◽  
Subcutaneous Fat ◽  
Premenopausal Women ◽  
Energy Deficit ◽  
Fat Accumulation ◽  
Visceral Fat Accumulation ◽  
Obese Subjects

Seventy-eight healthy obese subjects, 40 premenopausal women and 38 men aged 27-51 yr received a 4.2 MJ/day energy-deficit diet for 13 wk. Resting metabolic rate (RMR) and diet-induced thermogenesis (DIT) were measured by indirect calorimetry. Abdominal subcutaneous and visceral fat areas were calculated from magnetic resonance imaging scans before and after weight loss. Before weight loss, visceral fat accumulation was positively correlated with higher levels of RMR (P < 0.05) and DIT (P < 0.01) in women but not in men. The mean weight reduction was 12.2 +/- 3.5 (SD) kg. In men but not in women, an initially large visceral fat depot was associated with a reduced loss of weight and total fat mass (P < 0.05). Within each sex, an initial abundance of visceral fat was significantly related to a larger loss of visceral fat (P < 0.001) and in men to a smaller loss of subcutaneous fat (P < 0.05). These results suggest that there may be gender differences in the associations between visceral fat accumulation and components of energy expenditure (RMR and DIT) in obese subjects. Obese subjects with an initial abundance of visceral fat do not lose more body weight but more visceral fat than subjects with less visceral fat.

Contribution of visceral fat accumulation to the development of atherosclerosis in non-obese subjects

1994 ◽  
Vol 109 (1-2) ◽  
pp. 34
Author(s):  
T. Nakamura ◽  
K. Tokunaga ◽  
S. Yamashita ◽  
K. Kotani ◽  
T. Arai ◽  
...  
Keyword(s):  
Visceral Fat ◽  
Fat Accumulation ◽  
Visceral Fat Accumulation ◽  
Obese Subjects

scholarly journals Effects of Visceral Fat Accumulation Awareness on a Web-Based Weight-Loss Program: Japanese Study of Visceral Adiposity and Lifestyle Information—Utilization and Evaluation (J-VALUE)

ISRN Obesity ◽  
2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Naoki Sakane ◽  
Seitaro Dohi ◽  
Koichi Sakata ◽  
Shin-ichi Hagiwara ◽  
Toshihisa Morimoto ◽  
...  
Keyword(s):  
Weight Loss ◽  
Visceral Fat ◽  
Weight Loss Program ◽  
Control Group ◽  
Self Awareness ◽  
Hospital Organization ◽  
Web Based ◽  
Fat Accumulation ◽  
Healthy Behaviors ◽  
Visceral Fat Accumulation

A reduction of visceral fat is important for improvement of metabolic risk. This study was designed to compare the effects of a web-based program alone or together with measurement and self-awareness of accumulated visceral fat in Japanese workers. A new noninvasive device to measure visceral fat accumulation was introduced, and efficacy on weight-loss and improvement of healthy behaviors were examined. This study was conducted according to Helsinki declaration and approved by the ethical committee of Japan Hospital Organization, National Kyoto Hospital. Two-hundred and sixteen overweight and obese males with BMI of more than 23 participated from 8 healthcare offices of 3 Japanese private companies. Subjects were randomly allocated into control group, Web-based weight-loss program (Web), or Web + Visceral fat measurement group (Web + VFA). Eighty-one percent of participants completed the study. Reductions of body weight, waist circumference, and BMI were the largest in Web + VFA group, and the differences between groups were significant by ANOVA. Improvements of healthy behaviors were the largest in Web + VFA group, and the differences of healthy eating improvement scores between Web + VFA and control groups were significant. Our findings suggest that measurement and awareness of visceral fat are effective in weight reduction in overweight and obese males in the workplace.

Abstract 13081: Predictive Value of Visceral-to-subcutaneous Fat Ratio for Long-term Clinical Outcomes in Patients With Suspected Coronary Artery Disease

Circulation ◽  
2020 ◽  
Vol 142 (Suppl_3) ◽  
Author(s):  
Keisuke Machida ◽  
Kyuhachi Otagiri ◽  
Tadashi Itagaki ◽  
Takahiro Takeuchi ◽  
Hiroshi Kitabayashi
Keyword(s):  
Coronary Artery ◽  
Visceral Fat ◽  
Cardiovascular Events ◽  
Subcutaneous Fat ◽  
Coronary Risk Factors ◽  
Long Term Outcomes ◽  
Fat Accumulation ◽  
Visceral Fat Accumulation ◽  
Coronary Syndrome

Introduction: Although visceral fat accumulation is an important risk factor for coronary artery diseases (CAD), the relationship between visceral fat accumulation and its long-term outcomes has not been extensively investigated. Hypothesis: In patients with suspected CAD, the distribution of subcutaneous fat and visceral fat is associated with cardiovascular events. Methods: Computed tomography (CT) angiographies (CTA) were performed on 945 consecutive patients with suspected CAD. Plain abdominal CT scanning was performed to measure the patients’ visceral fat area (VFA) and subcutaneous fat area (SFA). The VFA/SFA (V/S) ratios were calculated to assess the visceral fat accumulation. Based on the results of the CTA, the prevalence of CAD was assessed. The patients were classified into low (<0.627), and high (≥0.627) V/S ratio groups, based on their median value, and the association between V/S ratio and long-term outcomes was evaluated. The primary endpoints were major cardiac adverse events (MACE), including all-cause death, new-onset acute coronary syndrome (ACS), emergent hospitalization due to cardiovascular disease, and any coronary revascularization. Results: The average follow-up period was 845.3 days. The baseline characteristics for patients in the high V/S ratio group were worse than those for patients in the low high V/S ratio group. As compared to the low V/S ratio group, a higher incidence of MACE and ACS, and a higher tendency of mortality was observed in the high V/S ratio group. After adjusting for traditional coronary risk factors, the V/S ratio was independently associated with incidence of MACE, ACS, and increase of mortality (table). Conclusions: The present study suggests that the V/S ratio is an independent predictor of long-term outcomes in patients with suspected CAD. The visceral fat accumulation indicated by high V/S ratio signifies a potential risk and may contribute to the future cardiovascular events in patients with suspected CAD.

scholarly journals Visceral fat and insulin resistance — causative or correlative?

2000 ◽  
Vol 83 (S1) ◽  
pp. S71-S77 ◽  
Author(s):  
Keith N. Frayn
Keyword(s):  
Insulin Resistance ◽  
Fatty Acids ◽  
Portal Vein ◽  
Visceral Fat ◽  
Subcutaneous Fat ◽  
Causal Link ◽  
Abdominal Fat ◽  
High Rate ◽  
Fat Accumulation ◽  
Visceral Fat Accumulation

The association between abdominal fat accumulation and risk of chronic diseases, including type II diabetes and coronary heart disease, has long been recognized. Insulin resistance may be a key factor in this link. Many studies have pointed to an association between insulin resistance and intra-abdominal fat accumulation (visceral obesity). However there is no clear proof of a causal link between visceral fat accumulation and insulin resistance. In assessing the probability of a causal link, it is useful to consider potential mechanisms. One such potential causal link is the release of non-esterified fatty acids from visceral fat into the portal vein, so that they have direct effects on hepatic metabolism. Visceral fat has been shown in many studies to exhibit a high rate of lipolysis compared with subcutaneous fat depots. However, if the idea that visceral fat releases fatty acids into the portal vein at a high rate is examined critically, a number of difficulties appear. Not least of these is the fact that continued high rates of lipolysis should lead to the disappearance of the visceral fat depot, unless these high rates of fat mobilization are matched by high rates of fat deposition. There is far less evidence for high rates of fat deposition in visceral adipose tissue, and some contrary evidence. Evidence for high rates of visceral lipolysis in vivo from studies involving catheterization of the portal vein is not strong. If this potential link is discounted, then other reasons for the relationship between visceral fat and insulin resistance must be considered. One is that there is no direct causal link, but both co-correlate with some other variable. A possibility is that this other variable is subcutaneous abdominal fat, which usually outweighs intra-abdominal fat several-fold. Subcutaneous fat probably plays the major role in determining systemic plasma non-esterified fatty acid concentrations, which are relevant in determining insulin resistance. In conclusion, there is at present no proof of a causal link between visceral fat accumulation and insulin resistance, or the associated metabolic syndrome. The possibility of co-correlation with some other factor, such as subcutaneous abdominal fat accumulation, must not be forgotten.

scholarly journals Association Between Visceral Fat Accumulation and Exercise Tolerance in Non-Obese Subjects Without Diabetes

2018 ◽  
Vol 10 (8) ◽  
pp. 630-635 ◽  
Author(s):  
Miki Shioya-Yamada ◽  
Kazunori Shimada ◽  
Miho Nishitani-Yokoyama ◽  
Eiryu Sai ◽  
Kageumi Takeno ◽  
...  
Keyword(s):  
Visceral Fat ◽  
Exercise Tolerance ◽  
Fat Accumulation ◽  
Visceral Fat Accumulation ◽  
Obese Subjects
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