scholarly journals Preeclampsia Is Associated with Low Circulating Levels of Insulin-Like Growth Factor I and 1,25-Dihydroxyvitamin D in Maternal and Umbilical Cord Compartments*

2000 ◽  
Vol 85 (5) ◽  
pp. 1828-1833 ◽  
Author(s):  
Ali Halhali ◽  
Armando R. Tovar ◽  
Nimbe Torres ◽  
Hector Bourges ◽  
Michele Garabedian ◽  
...  
Keyword(s):  
Growth Factor ◽  
Umbilical Cord ◽  
Fetal Growth ◽  
Insulin Like Growth Factor ◽  
Cord Serum ◽  
Dihydroxyvitamin D ◽  
Factor I ◽  
1,25 Dihydroxyvitamin D ◽  
Igf I ◽  
Circulating Levels

Abstract Insulin-like growth factor I (IGF-I) stimulates renal and placental 1,25-dihydroxyvitamin D [1,25-(OH)2D] and is considered an important regulator of fetal growth. As 1,25-(OH)2D and birth weight are low in preeclampsia, this study was undertaken to determine whether circulating levels of IGF-I were associated with serum 1,25-(OH)2D concentrations in preeclamptic (PE group) and normotensive (NT group) pregnancies. Maternal and umbilical cord serum levels of IGF-I and 1,25-(OH)2D were significantly (P < 0.01) lower in the PE group than in the NT group. The concentrations of these two hormones correlated significantly in the umbilical cord (P < 0.05) and in the maternal (P < 0.001) compartments of the PE and NT groups, respectively. The amount of IGFBP-3 was 64% lower whereas that of IGFBP-1 was 2.9-fold higher in umbilical cord serum of the PE group compared with the NT group. In addition, maternal and umbilical cord serum IGF-I correlated significantly (P < 0.05) with weight and length at birth only in the PE group. In conclusion, the results of this study indicate that circulating IGF-I and 1,25-(OH)2D levels in both maternal and umbilical cord compartments are low in preeclampsia. Furthermore, this study suggests a differential regulatory effect of IGF-I on 1,25-(OH)2D synthesis and fetal growth depending on the presence or absence of preeclampsia.

The concentration of insulin-like growth factor-I and insulin-like growth factor-binding protein-1 in human umbilical cord serum at delivery: relation to fetal weight

1991 ◽  
Vol 129 (3) ◽  
pp. 459-464 ◽  
Author(s):  
H. S. Wang ◽  
J. Lim ◽  
J. English ◽  
L. Irvine ◽  
T. Chard
Keyword(s):  
Growth Factor ◽  
Umbilical Cord ◽  
Fetal Growth ◽  
Gestational Age ◽  
Umbilical Artery ◽  
Binding Protein ◽  
Insulin Like Growth Factor ◽  
Factor Binding ◽  
Factor I ◽  
Igf I

ABSTRACT Serum levels of insulin-like growth factor-I (IGF-I) and insulin-like growth factor-binding protein-1 (IGFBP-1) have been determined by radioimmunoassay in the maternal circulation (n = 91) and in the umbilical artery (n = 56) and vein (n = 90) of man. In both the umbilical artery and vein, the concentration of serum IGF-I showed an inverse correlation with birthweight (P < 0·005 and P < 0·001 respectively); the mean serum IGF-I levels in the small-for-gestational-age (SGA) group were significantly higher than those in average-for-gestational-age (AGA) neonates (P <0·01 and P < 0·001 respectively). However, maternal serum IGF-I showed no association with birthweight and there was no significant difference between the SGA and AGA groups. These observations imply that the production of IGF-I in the maternal and fetal compartments is independent and that there is unlikely to be transfer of IGF-I across the placenta. Serum IGFBP-1 levels in both maternal and umbilical cord blood (artery and vein) showed an inverse relation to birthweight (P <0·001, P<0·005 and P<0·001 respectively). Increased IGFBP-1 levels in the umbilical artery and vein were observed in the SGA group. These findings suggest that IGFBP-1 might inhibit the action of IGF-I in both the maternal and the fetal compartments and that the rise in IGFBP-1 could be a primary factor in retardation of fetal growth. Alternatively, circulating IGF-I and IGFBP-1 levels may only be a secondary reflection of local tissue events involved in fetal growth. Journal of Endocrinology (1991) 129, 459–464

Relative Deficiency in Circulating Levels of Insulin-Like Growth Factor I (IGF-I) During Long-Term Treatment with a GnRH Agonist

1997 ◽  
Vol 29 (09) ◽  
pp. 472-474
Author(s):  
C. Fiore ◽  
M. Dieli ◽  
S. Caschetto ◽  
A. Cirino ◽  
E. Cottini
Keyword(s):  
Growth Factor ◽  
Gnrh Agonist ◽  
Term Treatment ◽  
Insulin Like Growth Factor ◽  
Factor I ◽  
Long Term Treatment ◽  
Igf I ◽  
Relative Deficiency ◽  
Circulating Levels

scholarly journals Circulating levels of insulin-like growth factor-I (IGF-I) correlate with disease status in leprosy

2011 ◽  
Vol 11 (1) ◽  
Author(s):  
Luciana Silva Rodrigues ◽  
Mariana Andrea Hacker ◽  
Ximena Illarramendi ◽  
Maria Fernanda Miguens Castelar Pinheiro ◽  
José Augusto da Costa Nery ◽  
...  
Keyword(s):  
Growth Factor ◽  
Disease Status ◽  
Insulin Like Growth Factor ◽  
Factor I ◽  
Igf I ◽  
Growth Factor I ◽  
Circulating Levels

Insulin-like growth factor I promotes growth selectively in fetal sheep in late gestation

1996 ◽  
Vol 270 (5) ◽  
pp. R1148-R1155 ◽  
Author(s):  
F. Lok ◽  
J. A. Owens ◽  
L. Mundy ◽  
J. S. Robinson ◽  
P. C. Owens
Keyword(s):  
Growth Factor ◽  
Fetal Growth ◽  
Late Gestation ◽  
Skeletal Maturation ◽  
Long Bones ◽  
Insulin Like Growth Factor ◽  
Fetal Sheep ◽  
Factor I ◽  
Igf I ◽  
Growth Factor I

Insulin-like growth factor I (IGF-I) is required for normal fetal growth and skeletal maturation in late gestation, because null mutations of the IGF-I gene in mice reduce fetal weight and retard ossification of bones. To determine if, conversely, increased abundance of IGF-I promotes fetal growth and skeletal maturation, fetal sheep were infused intravascularly with recombinant human IGF-I (n = 7) (26 +/- 3 micrograms. h-1.kg-1) from 120 to 130 days gestation and compared with controls (n = 15). IGF-I infusion increased plasma IGF-I concentrations by 140% (P = 0.002) and weights of fetal liver, lungs, heart, kidneys, spleen, pituitary, and adrenal glands by 16-50% (P < 0.05). Weights and/or lengths of the fetus, placenta, gastrointestinal tract, individual skeletal muscles, and long bones were unchanged by IGF-I. However, IGF-I increased the percentage of proximal epiphyses of long bones present (P < 0.05) and their cross-sectional areas by 15 to 38% (P < 0.05). These results show that IGF-I promotes growth of major fetal organs, endocrine glands, and skeletal maturation in vivo, consistent with IGF-I actively controlling and not merely facilitating fetal growth. The variable response of different tissues may partly reflect tissue specificity in growth requirements for additional factors.

scholarly journals Effect of Low-Intensity Aerobic Exercise on Insulin-Like Growth Factor-I and Insulin-Like Growth Factor-Binding Proteins in Healthy Men

2010 ◽  
Vol 2010 ◽  
pp. 1-8 ◽  
Author(s):  
Yuichiro Nishida ◽  
Takeshi Matsubara ◽  
Takuro Tobina ◽  
Munehiro Shindo ◽  
Kumpei Tokuyama ◽  
...  
Keyword(s):  
Growth Factor ◽  
Aerobic Exercise ◽  
Binding Proteins ◽  
Aerobic Training ◽  
Insulin Like Growth Factor ◽  
Healthy Men ◽  
Factor I ◽  
Low Intensity ◽  
Igf I ◽  
Circulating Levels

Increased concentrations of circulating insulin-like growth factor-I (IGF-I) or IGF-I relative to IGF-binding proteins (IGFBPs) are associated with increased risk of developing several forms of cancer. Conversely, exercise is linked with reduced risk. This study aims to investigate the effect of a low-intensity exercise program on circulating levels of IGF-I, IGFBP-1, and IGFBP-3, in previously sedentary males. Fourteen healthy men participated in cycle ergometer training at lactate threshold intensity for 60 min/day, 5 days/week for 6 weeks. After aerobic training, insulin sensitivity improved by 20%, while fasting insulin levels decreased by 13%. Simultaneously, low-intensity aerobic training decreased the circulating levels of IGF-I by 9%, while IGFBP-1 levels increased by 16%. An interesting finding was that higher pretraining level of IGF-I was associated with greater decline in IGF-I with training. Insulin-sensitizing low-intensity aerobic exercise is thus considered to be an effective method for downregulating IGF-I and upregulating IGFBP-1 levels.

Insulin-like growth factor I and growth hormone in canine starvation

1985 ◽  
Vol 108 (2) ◽  
pp. 161-166 ◽  
Author(s):  
J. Eugen Eigenmann ◽  
Jan. J. de Bruijne ◽  
E. Rudolf Froesch
Keyword(s):  
Growth Hormone ◽  
Growth Factor ◽  
Insulin Like Growth Factor ◽  
Drastic Reduction ◽  
Factor I ◽  
Igf I ◽  
Growth Factor I ◽  
Plasma Gh ◽  
Circulating Levels ◽  
Secretory Capacity

Abstract. The roles of plasma insulin-like growth factor I (IGF I) and growth hormone (GH) were studied in 7 beagle dogs before and during starvation and during refeeding. IGF I levels significantly decreased from 75.2 ± 5.9 ng/ml at 7 days prior to the start of starvation to 9 ± 1.7 ng/ml at 19 days after the commencement of starvation (mean ± sem; P < 0.0001). During refeeding IGF I significantly rose from 9 ± 1.7 ng/ml to 55.5 ± 7.5 ng/ml within 9 days (mean ± sem; P < 0.002). During starvation plasma GH levels significantly increased (P < 0.05) and these elevated levels returned to normal during refeeding. The dogs' GH secretory capacity significantly increased during starvation (P = 0.012) and became normal again during refeeding. The following conclusions can be drawn from this study: 1) starvation in the dog leads to a significant and drastic reduction of the circulating levels of IGF I, and 2) starvation in the dog, as in man, leads to increased circulating GH levels and to an increased GH-secretory capacity possibly brought about by a lack of a negative feedback normally exerted by IGF I.

Dietary Phosphorus and 1,25-Dihydroxyvitamin D Metabolism: Influence of Insulin-Like Growth Factor I*

Endocrinology ◽  
1988 ◽  
Vol 123 (3) ◽  
pp. 1225-1229 ◽  
Author(s):  
BERNARD P. HALLORAN ◽  
E. MARTIN SPENCER
Keyword(s):  
Growth Factor ◽  
Insulin Like Growth Factor ◽  
Dihydroxyvitamin D ◽  
Factor I ◽  
1,25 Dihydroxyvitamin D ◽  
Dietary Phosphorus ◽  
Growth Factor I
Sign in / Sign up

Export Citation Format

Share Document