Circulating levels of insulin-like growth factor-I (IGF-I) correlate with disease status in leprosy

Abstract. The roles of plasma insulin-like growth factor I (IGF I) and growth hormone (GH) were studied in 7 beagle dogs before and during starvation and during refeeding. IGF I levels significantly decreased from 75.2 ± 5.9 ng/ml at 7 days prior to the start of starvation to 9 ± 1.7 ng/ml at 19 days after the commencement of starvation (mean ± sem; P < 0.0001). During refeeding IGF I significantly rose from 9 ± 1.7 ng/ml to 55.5 ± 7.5 ng/ml within 9 days (mean ± sem; P < 0.002). During starvation plasma GH levels significantly increased (P < 0.05) and these elevated levels returned to normal during refeeding. The dogs' GH secretory capacity significantly increased during starvation (P = 0.012) and became normal again during refeeding. The following conclusions can be drawn from this study: 1) starvation in the dog leads to a significant and drastic reduction of the circulating levels of IGF I, and 2) starvation in the dog, as in man, leads to increased circulating GH levels and to an increased GH-secretory capacity possibly brought about by a lack of a negative feedback normally exerted by IGF I.

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Circulating levels of insulin-like growth factor binding protein 3 (IGFBP-3) and insulin-like growth factor I (IGF-I) in perimenopausal women

Osteoporosis International ◽

10.1007/bf01622187 ◽

1994 ◽

Vol 4 (6) ◽

pp. 305-308 ◽

Cited By ~ 16

Author(s):

E. Romagnoli ◽

S. Minisola ◽

V. Carnevale ◽

R. Rosso ◽

M. T. Pacitti ◽

...

Keyword(s):

Growth Factor ◽

Binding Protein ◽

Insulin Like Growth Factor ◽

Factor Binding ◽

Factor I ◽

Perimenopausal Women ◽

Igf I ◽

Growth Factor I ◽

Circulating Levels ◽

Igfbp 3

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Role of testosterone in regulating the growth of mice from lines selected for low vs high plasma insulin-like growth factor-I concentrations

Acta Endocrinologica ◽

10.1530/acta.0.1210686 ◽

1989 ◽

Vol 121 (5) ◽

pp. 686-690 ◽

Cited By ~ 4

Author(s):

Rafat A. Siddiqui ◽

Stuart N. McCutcheon ◽

Duncan D. S. Mackenzie ◽

Hugh T. Blair ◽

J. Eldon Ormsby ◽

...

Keyword(s):

Body Weight ◽

Growth Factor ◽

High Plasma ◽

Insulin Like Growth Factor ◽

Factor I ◽

Pubertal Growth ◽

Igf I ◽

Growth Factor I ◽

Circulating Levels

Abstract. A study was undertaken to investigate the role of testosterone in regulating growth and circulating levels of insulin-like growth factor-I in male mice from lines divergently selected on the basis of plasma IGF-I. Controls of each lines were sham-operated at 10 days of age and treated with peanut oil from day 14 to day 70. A second group, which was castrated at 10 days and treated with testosterone enanthate (0.5 μg · (g body weight) −1 · day−1) from day 14 to 70, did not differ from controls in body weight but had higher plasma IGF-I concentrations. Delaying testosterone therapy until day 42 in a third group retarded growth, with body weights being significantly lower than those of other two groups from days 35 to 56. However, plasma IGF-I levels in this group were not different from those of controls. Effects of line and treatment were additive. It is concluded that the greater pubertal growth of high-line compared to low-line males is not due to greater stimulation of circulating IGF-I by testosterone. Furthermore, testosterone does not appear to influence pubertal growth by acting on circulating levels of IGF-I.

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