scholarly journals SUN-313 Depression, Subjective Stress and Serum Osteocalcin Concentrations in People with Type 2 Diabetes Mellitus

2020 ◽  
Vol 4 (Supplement_1) ◽  
Author(s):  
Michelle My Linh Nguyen ◽  
Lina Darwish ◽  
Chelsi Major-Orfao ◽  
Jessica Colby-Milley ◽  
Sophie K Wong ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Perceived Stress ◽  
Depressive Episode ◽  
Mild Stress ◽  
Serum Osteocalcin ◽  
Subjective Stress ◽  
Dsm 5

Abstract Serum osteocalcin is emerging as a potential marker of glucose homeostasis and risk of type 2 diabetes mellitus (T2DM). In mice, osteocalcin knockouts exhibit depressive-like behaviours but knockouts of a putative osteocalcin receptor, GPR158, are resistant to chronic unpredictable mild stress. Recently, osteocalcin release from bone has been suggested to mediate some aspects of the acute stress response. Here, we assess relationships between serum osteocalcin, depression and perceived stress in people with T2DM. Participants with T2DM were assessed for whether they met the DSM-5 criteria for Major Depressive Disorder using the research version of the Structured Clinical Interview for DSM-5 depression criteria (SCID-5RV). Subjective stress was assessed using the Perceived Stress Scale (PSS) with higher scores indicating greater subjective stress. Serum carboxylated (cOCN) and uncarboxylated (unOCN) osteocalcin were assayed from fasting morning blood by commercial ELISA. Among 87 participants (mean age 62.9±9.5, 52% women), 18 (26%) were experiencing a depressive episode (7 men, 11 women). Both serum unOCN and cOCN were associated with higher PSS scores in participants with depression (unOCN, r=0.566, p=0.014; cOCN, r=0.564, p=0.015) but not in those without depression (unOCN, r=0.002, p=0.985; cOCN, r=0.090, p=0.463). A significant interaction was found between depression and PSS scores predicting serum unOCN in a linear model adjusted for age, sex, body mass index, antidepressant use and HbA1c (F=6.225, p=0.015). The results are consistent with reports that osteocalcin release from bone may be a mediator of stress perception; however, among people with T2DM, this relationship was observed only among those currently experiencing a depressive episode.

Low serum osteocalcin concentration is associated with incident type 2 diabetes mellitus in Japanese women

2017 ◽  
Vol 36 (4) ◽  
pp. 470-477 ◽  
Author(s):  
Tomohiko Urano ◽  
Masataka Shiraki ◽  
Tatsuhiko Kuroda ◽  
Shiro Tanaka ◽  
Fumihiko Urano ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Japanese Women ◽  
Serum Osteocalcin ◽  
Incident Type ◽  
Incident Type 2 Diabetes ◽  
Low Serum

Serum osteocalcin is associated with insulin sensitivity and secretion in postmenopausal women with type-2 diabetes mellitus

Bone ◽  
2012 ◽  
Vol 50 ◽  
pp. S142
Author(s):  
M.-S.M. Ardawi⁎ ◽  
A.A. Rouzi ◽  
D.H. Akbar ◽  
A.A. AlShaikh ◽  
M.M. Ahmed ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Insulin Sensitivity ◽  
Postmenopausal Women ◽  
Serum Osteocalcin

scholarly journals Effects of gender, age, family support, and treatment on perceived stress and coping of patients with type 2 diabetes mellitus

2014 ◽  
Vol 8 (1) ◽  
pp. 16 ◽  
Author(s):  
Yoriko Hara ◽  
Mizuho Hisatomi ◽  
Hisao Ito ◽  
Motoyuki Nakao ◽  
Koji Tsuboi ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Family Support ◽  
Perceived Stress ◽  
Stress And Coping ◽  
And Coping

Association between a guided meditation practice, sleep and psychological well-being in type 2 diabetes mellitus patients

2018 ◽  
Vol 15 (4) ◽  
Author(s):  
Mathew P Varghese ◽  
Ragavendrasamy Balakrishnan ◽  
Subramanya Pailoor
Keyword(s):  
Quality Of Life ◽  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Perceived Stress ◽  
Anxiety And Depression ◽  
Self Awareness ◽  
Meditation Practice

Abstract Background Type 2 diabetes mellitus [T2DM] is one of the leading causes for mortality. This study examined the role of an self-awareness based guided meditation practice, Cyclic Meditation [CM] on perceived stress, anxiety, depression, sleep and quality of life in T2DM patients. Design A single arm pre-post design was used for the study. Setting The study was conducted in an auditorium for general public diagnosed with T2DM in Ernakulam, Kerala, India. Subjects Subjects were 30 T2DM patients, both male and female of age 50.12 ± 11.15 years and BMI 25.14 ± 4.37 Kg/m2 and not having a history of hospitalisation were randomly recruited for the study following advertisements in national dailies. Intervention Participants completed a supervised CM programs in the evenings, 5 days a week for 4 weeks, in addition to their regular medication. Measures Perceived stress, anxiety and depression were assessed with Perceived Stress Scale, State Anxiety Inventory and Beck’s depression inventory, respectively. Sleep and quality of life were assessed with Pittsburgh Sleep Quality Index and WHO-Quality of Life – BREF respectively. Analysis Changes in the outcome measures from baseline to 4 weeks were compared using paired “t” test. Results After 4 weeks, the quality of life and sleep scores increased 7.1% [p = 0.001] and 32.7% [p = 0.001], respectively. The perceived stress, anxiety and depression reduced 26.1% [p = 0.001], 16.01% [p = 0.003] and 37.63% [p = 0.006] as compared to their baseline reports. The CM practice also reduced daytime dysfunction. Conclusions A guided self-awareness based meditation program was safe and effective in improving depression, anxiety, perceived stress and enhance sleep and quality of life in T2DM patients, which could be helpful in reducing the future complications of T2DM. Mind management is essential along with medical management to achieve better clinical results.

The Relationship between Serum Osteocalcin Concentration and Glucose and Lipid Metabolism in Patients with Type 2 Diabetes Mellitus - The Role of Osteocalcin in Energy Metabolism

2015 ◽  
Vol 66 (2-3) ◽  
pp. 110-116 ◽  
Author(s):  
Xiao-yu Ma ◽  
Fen-qin Chen ◽  
Hong Hong ◽  
Xiu-juan Lv ◽  
Ming Dong ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Lipid Metabolism ◽  
Serum Osteocalcin ◽  
Relevant Factor ◽  
Male Group ◽  
Glucose And Lipid Metabolism ◽  
The Relationship

Background: Recent animal studies have found that the osteocalcin secreted by osteoblasts could participate in glucose and lipid metabolism. Our study aimed to investigate the relationship between serum osteocalcin concentration and glucose and lipid metabolism in patients with type 2 diabetes mellitus. Methods: 985 patients with type 2 diabetes were divided into the male group (n = 495) and the postmenopausal female group (n = 490). The average ages were 54.42 ± 10.535 and 64.93 ± 9.277, respectively. We collected the parameters of age, duration, fasting plasma glucose, HbA1c, fasting insulin, fasting C peptide, blood lipid, 25 (OH) VD3, parathyroid hormone (PTH), Alkaline phosphatase (ALP), procollagen type 1 N-terminal propeptide (P1NP), β-C-terminal telopeptide of type I collagen (β-CTx), osteocalcin, HOMA-IR, HOMA-β, body mass index (BMI), and waist-to-hip ratio (WHR). The relationship of osteocalcin and these parameters were analyzed by Pearson/Spearman correlation analysis and stepwise multiple regression analysis. Results: Osteocalcin was negatively correlated with HbA1c (p < 0.05) and it was also an independent relevant factor affecting HbA1c in both groups. Osteocalcin was positively correlated with HOMA-β and it was an independent relevant factor affecting HOMA-β in male group (p < 0.01). Conclusions: These findings indicate the association between serum osteocalcin and glucose metabolism and beta cell function. No relationship was found between osteocalcin and insulin resistance and lipid metabolism in type 2 diabetes.

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