Alimentary Infections by Tick-Borne Encephalitis Virus

Tick-borne encephalitis virus (TBEV) causes serious the neurological disease, tick-borne encephalitis (TBE). TBEV can be transmitted to humans by ticks as well as by the alimentary route, which is mediated through the consumption of raw milk products from infected ruminants such as sheep, goats, and cows. The alimentary route of TBEV was recognized in the early 1950s and many important experimental studies were performed shortly thereafter. Nowadays, alimentary TBEV infections are recognized as a relevant factor contributing to the overall increase in TBE incidences in Europe. This review aims to summarize the history and current extent of alimentary TBEV infections across Europe, to analyze experimental data on virus secretion in milk, and to review possible alimentary infection preventive measures.

The consecutive disparity of precipitation in conterminous Spain

Precipitation irregularity constitutes a constraint for natural systems and socio-economic activities, particularly in water-scarce environments. Standard variability statistics such as the standard deviation, variance, and coefficient of variation do not consider the chronological order of these values. In Climatology, however, the temporal order of meteorological events is a relevant factor that can affect natural and socio-economic systems. In order to evaluate the disparity between consecutive values in precipitation series, we applied the Consecutive Disparity Index (D) to the monthly grid with the highest spatial resolution (10×10 km) existing in Peninsular Spain for the period December 1915–November 2015. Monthly, seasonal, and annual D values show an increase from north to southwest, especially in July and August. The D values for the month-to-month correlative series and for monthly mean precipitation reveal a relatively similar pattern. In the latter case, however, the low values are recorded towards southern Spain, following some mountain ranges in the Centre-East of the territory. Monthly, seasonal, and annual precipitation values are also negatively correlated with the corresponding D values.

Defining the territory size of a Geographical Indication

The objective of this study is to map articles that present models for determining the territory size of Geographical Indications (GIs), a relevant factor for the management of GIs that is poorly explored in studies on the subject. The study was undertaken as a systematic mapping study (SMS), whose main objective is to identify accessible facts about a given research topic, which is also the most suitable approach when aiming to analyze the state of the art of a subject with little evidence available in the literature. Using the Scopus and Web of Science databases, in which 671 results were found, and the StArt tool to select the articles, 652 articles were excluded (30 duplicates and 622 that did not meet the inclusion criteria established in the systematic mapping protocol). Then, after a complete reading of the texts of the 19 remaining articles, 14 were excluded. Thus, this study included only five articles in which GI size models were developed, the oldest of which was published in 2007 and the most recent in 2021. We therefore conclude that few studies are available in the literature on this theme.

Influenza B Lineages Have More in Common Than Meets the Eye. Trivalent Influenza Vaccines Trigger Heterotypic Antibodies Against Both Influenza B Viruses

Influenza B is accountable for an important burden during flu epidemics, causing special impact in children and the elderly. Vaccination is the best approach to address influenza infections. However, one of the main problems of this virus is that two different lineages circulate together, Victoria and Yamagata; and trivalent vaccines, that only contain one of these lineages, are still in use. For that reason, if during an epidemic, the lineage not included in the vaccine predominates, a mismatch would occur, and the vaccine effectiveness will be very poor. In this work, we evaluated the cross-protection given by the trivalent Influenza vaccine and compared serological profiles based on age, sex, and the type of vaccine used. We performed a retrospective analysis of serum samples obtained before and after seasonal influenza vaccination during 20 seasons (1998–2018). The results showed that heterotypic reactivity between both influenza B lineages is common, but always lower than the homologous response. Age is a relevant factor for this cross-reactivity between both lineages, while the sex and the type of vaccine not. Vaccination with trivalent influenza vaccines elicits cross-reactive antibodies against both lineages, however, this response might not be enough to provide an appropriate serological protection in case of mismatch.

Microvariação na resolução de sujeitos pronominais: português europeu vs. italiano

The present study investigates the resolution of null and overt subject pronouns in intrasentential contexts, considering the role of animacy in antecedent assignment. Participants were 15 native speakers of EP and 14 of Italian. Each language group was administered two multiple choice tasks (speeded and untimed), which had a 2x2 design, crossing the following variables: animacy of the matrix object (animate vs. inanimate) and type of pronominal embedded subject (overt vs. null). Results indicate that there is microvariation in the resolution of overt pronominal subjects in EP and in Italian: the position of the antecedent is the most relevant factor in EP, whereas, in Italian, the animacy of the antecedent is the preponderant factor. Results also show that there is microvariation in the resolution of null subjects (contra previous claims in the literature): the bias for subject antecedents is weaker in Italian than in EP. Possible reasons for the observed microvariation are discussed in detail.

Multivariate Approach to Reading Comprehension and Sight-Reading

This chapter focuses on the study of the relationship between reading of music and verbal texts and it seeks to define an ecological music reading task that allows comparison of musical and verbal domains. Participants were preservice music students who performed different music reading tasks correlated with a verbal text comprehension test. A Principal Component Analysis (PCA), was performed, explaining 91,5% of the variance. The following two axes were defined: one related to reading compression and the other to music performance variables. The relationship between the selected variables in the factorial plane, particularly the strong association between sight-reading and literal comprehension, suggest that sight-reading is a relevant factor with regards to the study of musical and verbal domains.

Difficulties Detecting Clinically Relevant Factor Xa Inhibitor Levels Prior to Reversal With Andexanet Alfa for Intracranial Hemorrhage

Coagulation factor Xa (recombinant), inactivated-zhzo (andexanet alfa) is approved for reversal of life-threatening bleeding with rivaroxaban and apixaban use. Clinical decision-making to initiate reversal is reliant on dose taken and timing of last dose. In practice, timing of last dose may be unknown, and the turnaround time for drug-specific anti-factor Xa levels at some institutions may be prolonged, leaving clinicians balancing a difficult decision with limited tools. This report includes a series of 3 patients who presented to our institution with an intracranial hemorrhage and received andexanet alfa for apixaban reversal. These cases highlight the challenges clinicians are facing when using andexanet alfa for emergent rivaroxaban or apixaban reversal when the timing of last dose is unknown, or patients fall outside of the recommended timeframe for use and clinically relevant drug levels are still suspected. Based on our experiences, we encourage other institutions to evaluate their abilities to rapidly and accurately detect the presence of clinically relevant rivaroxaban and apixaban levels when utilizing andexanet alfa.

The TGF-β /NADPH Oxidases Axis in the Regulation of Liver Cell Biology in Health and Disease

The Transforming Growth Factor-beta (TGF-β) pathway plays essential roles in liver development and homeostasis and become a relevant factor involved in different liver pathologies, particularly fibrosis and cancer. The family of NADPH oxidases (NOXs) has emerged in recent years as targets of the TGF-β pathway mediating many of its effects on hepatocytes, stellate cells and macrophages. This review focuses on how the axis TGF-β/NOXs may regulate the biology of different liver cells and how this influences physiological situations, such as liver regeneration, and pathological circumstances, such as liver fibrosis and cancer. Finally, we discuss whether NOX inhibitors may be considered as potential therapeutic tools in liver diseases.