scholarly journals Cell Cycle Progression and Activation of Akt Kinase Are Required for Insulin-Like Growth Factor I-Mediated Suppression of Apoptosis in Granulosa Cells

2004 ◽  
Vol 18 (2) ◽  
pp. 326-338 ◽  
Author(s):  
Che-Lin Hu ◽  
Robert G. Cowan ◽  
Rebecca M. Harman ◽  
Susan M. Quirk
Keyword(s):  
Cell Cycle ◽  
Growth Factor ◽  
Granulosa Cells ◽  
Cell Cycle Progression ◽  
Insulin Like Growth Factor ◽  
Akt Kinase ◽  
Cycle Progression ◽  
Factor I ◽  
Growth Factor I

scholarly journals 14-3-3σ Mediation of Cell Cycle Progression Is p53-independent in Response to Insulin-like Growth Factor-I Receptor Activation

2004 ◽  
Vol 279 (33) ◽  
pp. 34353-34360 ◽  
Author(s):  
Yang Zhang ◽  
Michael Karas ◽  
Hong Zhao ◽  
Shoshana Yakar ◽  
Derek LeRoith
Keyword(s):  
Cell Cycle ◽  
Growth Factor ◽  
Cell Cycle Progression ◽  
Receptor Activation ◽  
Insulin Like Growth Factor ◽  
Cycle Progression ◽  
Factor I ◽  
Growth Factor I

Lycopene Interferes With Cell Cycle Progression and Insulin-Like Growth Factor I Signaling in Mammary Cancer Cells

2000 ◽  
Vol 36 (1) ◽  
pp. 101-111 ◽  
Author(s):  
Michael Karas ◽  
Hadar Amir ◽  
Daniel Fishman ◽  
Michael Danilenko ◽  
Shraga Segal ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Growth Factor ◽  
Cancer Cells ◽  
Mammary Cancer ◽  
Cell Cycle Progression ◽  
Insulin Like Growth Factor ◽  
Cycle Progression ◽  
Factor I ◽  
Growth Factor I ◽  
Mammary Cancer Cells

Insulin-like growth factor-I prevents hypoxia-inducible factor-1 alpha-dependent G1/S arrest by activating cyclin E/cyclin-dependent kinase2 via the phoshatidylinositol-3 kinase/AKT/forkhead box O1/Cdkn1b pathway in porcine granulosa cells†

2019 ◽  
Author(s):  
Chengyu Li ◽  
Zhaojun Liu ◽  
Jiaqi Zhou ◽  
Xueqin Meng ◽  
Shuo Liu ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Growth Factor ◽  
Granulosa Cells ◽  
Cell Cycle Progression ◽  
Hypoxia Inducible Factor ◽  
Inhibitory Effects ◽  
Cycle Progression ◽  
Hypoxia Inducible Factor 1 ◽  
Factor I ◽  
Igf I

Abstract As the follicle develops, the thickening of the granulosa compartment leads to progressively deficient supply of oxygen in granulosa cells (GCs) due to the growing distances from the follicular vessels. These conditions are believed to cause hypoxia in GCs during folliculogenesis. Upon hypoxic conditions, several types of mammalian cells have been reported to undergo cell cycle arrest. However, it remains unclear whether hypoxia exerts any impact on cell cycle progression of GCs. On the other hand, although the GCs may live in a hypoxic environment, their mitotic capability appears to be unaffected in growing follicles. It thus raises the question whether there are certain intraovarian factors that might overcome the inhibitory effects of hypoxia. The present study provides the first evidence suggesting that cobalt chloride (CoCl2)-mimicked hypoxia prevented G1-to-S cell cycle progression in porcine GCs. In addition, we demonstrated that the inhibitory effects of CoCl2 on GCs cell cycle are mediated through hypoxia-inducible factor-1 alpha/FOXO1/Cdkn1b pathway. Moreover, we identified insulin-like growth factor-I (IGF-I) as an intrafollicular factor required for cell cycle recovery by binding to IGF-I receptor in GCs suffering CoCl2 stimulation. Further investigations confirmed a role of IGF-I in preserving G1/S progression of CoCl2-treated GCs via activating the cyclin E/cyclin-dependent kinase2 complex through the phoshatidylinositol-3 kinase/protein kinase B (AKT)/FOXO1/Cdkn1b axis. Although the present findings were based on a hypoxia mimicking model by using CoCl2, our study might shed new light on the regulatory mechanism of GCs cell cycle upon hypoxic stimulation.

scholarly journals The insulin-like growth factor-I receptor inhibitor NVP-AEW541 provokes cell cycle arrest and apoptosis in multiple myeloma cells

2008 ◽  
Vol 141 (4) ◽  
pp. 470-482 ◽  
Author(s):  
Patricia Maiso ◽  
Enrique M. Ocio ◽  
Mercedes Garayoa ◽  
Juan C. Montero ◽  
Francesco Hofmann ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Multiple Myeloma ◽  
Growth Factor ◽  
Cell Cycle Arrest ◽  
Insulin Like Growth Factor ◽  
Myeloma Cells ◽  
Factor I ◽  
Cycle Arrest ◽  
Growth Factor I ◽  
Receptor Inhibitor

Characterization and Regulation of a Specific Cell Membrane Receptor for Somatomedin-C/Insulin-Like Growth Factor I in Cultured Rat Granulosa Cells*

Endocrinology ◽  
1988 ◽  
Vol 122 (1) ◽  
pp. 194-201 ◽  
Author(s):  
ELI Y. ADASHI ◽  
CAROL E. RESNICK ◽  
ELEUTERIO R. HERNANDEZ ◽  
MARJORIE E. SVOBODA ◽  
JUDSON J. VAN WYK
Keyword(s):  
Growth Factor ◽  
Cell Membrane ◽  
Granulosa Cells ◽  
Membrane Receptor ◽  
Specific Cell ◽  
Insulin Like Growth Factor ◽  
Somatomedin C ◽  
Factor I ◽  
Growth Factor I
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