Essential role of tyrosine residues 1131, 1135, and 1136 of the insulin-like growth factor-I (IGF-I) receptor in IGF-I action.

Oxidative stress is a proposed mechanism in brain aging, making the study of its regulatory processes an important aspect of current neurobiological research. In this regard, the role of the aging regulator insulin-like growth factor I (IGF-I) in brain responses to oxidative stress remains elusive as both beneficial and detrimental actions have been ascribed to this growth factor.Because astrocytes protect neurons against oxidative injury, we explored whether IGF-I participates in astrocyte neuroprotection and found that blockade of the IGF-I receptor in astrocytes abrogated their rescuing effect on neurons. We found that IGF-I directly protects astrocytes against oxidative stress (H2O2). Indeed, in astrocytes but not in neurons, IGF-I decreases the pro-oxidant protein thioredoxin-interacting protein 1 and normalizes the levels of reactive oxygen species. Furthermore, IGF-I cooperates with trophic signals produced by astrocytes in response to H2O2 such as stem cell factor (SCF) to protect neurons against oxidative insult. After stroke, a condition associated with brain aging where oxidative injury affects peri-infarcted regions, a simultaneous increase in SCF and IGF-I expression was found in the cortex, suggesting that a similar cooperative response takes place in vivo. Cell-specific modulation by IGF-I of brain responses to oxidative stress may contribute in clarifying the role of IGF-I in brain aging.

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The role of insulin-like growth factor I (IGF-I) in treatment monitoring of acute lymphoblastic leukemia pediatric patients

10.35841/medical-oncology.2.1.6-10 ◽

2017 ◽

Vol 02 (01) ◽

Author(s):

Nabeela Sawaf ◽

Jomana Saleh

Keyword(s):

Acute Lymphoblastic Leukemia ◽

Growth Factor ◽

Pediatric Patients ◽

Lymphoblastic Leukemia ◽

Treatment Monitoring ◽

Insulin Like Growth Factor ◽

Factor I ◽

Igf I ◽

Growth Factor I

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Role of insulin-like growth factor I (IGF-I) in firbosis induced by carbon tetrachloride

Journal of Hepatology ◽

10.1016/s0168-8278(00)80632-7 ◽

2000 ◽

Vol 32 ◽

pp. 78

Author(s):

S. Sanz ◽

C.M. Rodríguez-Ortigosa ◽

P.K. Lund ◽

J. Castilla-Cortàzar ◽

D.A. Brennert ◽

...

Keyword(s):

Carbon Tetrachloride ◽

Growth Factor ◽

Insulin Like Growth Factor ◽

Factor I ◽

Igf I ◽

Growth Factor I

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The Effects of Physical Activity and Fitness in Adolescence on Cognition in Adulthood and the Role of Insulin-Like Growth Factor I

Journal of Physical Activity and Health ◽

10.1123/jpah.2014-0594 ◽

2016 ◽

Vol 13 (4) ◽

pp. 392-402 ◽

Cited By ~ 4

Author(s):

Doeschka A. Ferro ◽

Jan Berend Deijen ◽

Lando L. Koppes ◽

Willem van Mechelen ◽

Jos W. Twisk ◽

...

Keyword(s):

Physical Activity ◽

Working Memory ◽

Growth Factor ◽

Spatial Working Memory ◽

Insulin Like Growth Factor ◽

Factor I ◽

Visual Spatial ◽

Igf I ◽

Growth Factor I

Background:Physical activity and fitness in adolescence may improve cognition in adulthood by increasing insulin-like growth factor I (IGF-I).Methods:As part of the Amsterdam Growth and Health Longitudinal Study, following subjects from age 13 to 42 years, physical activity and fitness of 303 subjects were assessed annually between the ages 13 to 16. At mean age 36, physical activity, fitness and IGF-I were measured. At mean age 42, IGF-I and cognitive factors (ie, executive functioning and visual-spatial memory) were measured. The linear regression of physical activity and fitness in adolescence and IGF-I in adulthood on cognitive scores in adulthood was investigated.Results:A significant association was found in males between physical activity in adolescence and executive function in adulthood (Spatial Working Memory Between Errors: β = –.18, B = –.13, 95% CI = –.259 to –.010; Spatial Working Memory Strategy: β = –.20, B = –.08, 95% CI = –.147 to –.014). No association between physical activity or fitness in adolescence and cognitive function in adulthood was found in females, nor any intermediate role for IGF-I in either sex.Conclusions:The results suggest a stimulating effect of adolescent physical activity in males on executive functions in adulthood, emphasizing the importance of an active lifestyle among adolescent males.

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