scholarly journals Outcomes after intracerebral hemorrhage from arteriovenous malformations

Neurology ◽  
2017 ◽  
Vol 88 (20) ◽  
pp. 1882-1888 ◽  
Author(s):  
Santosh B. Murthy ◽  
Alexander E. Merkler ◽  
Setareh Salehi Omran ◽  
Gino Gialdini ◽  
Aaron Gusdon ◽  
...  
Keyword(s):  
Intracerebral Hemorrhage ◽  
Nationwide Inpatient Sample ◽  
Predictor Variable ◽  
Population Based ◽  
Population Based Study ◽  
Home Discharge ◽  
Diagnosis Codes ◽  
Ruptured Avm ◽  
Confirmatory Analysis ◽  
Using Data

Objective:To compare outcomes after intracerebral hemorrhage (ICH) from cerebral arteriovenous malformation (AVM) rupture and other causes of ICH.Methods:We performed a retrospective population-based study using data from the Nationwide Inpatient Sample. We used standard diagnosis codes to identify ICH cases from 2002 to 2011. Our predictor variable was cerebral AVM. Our primary outcomes were inpatient mortality and home discharge. We used logistic regression to compare outcomes between patients with ICH with and without AVM while adjusting for demographics, comorbidities, and hospital characteristics. In a confirmatory analysis using a prospective cohort of patients hospitalized with ICH at our institution, we additionally adjusted for hematoma characteristics and the Glasgow Coma Scale score.Results:Among 619,167 ICH hospitalizations, the 4,485 patients (0.7%, 95% confidence interval [CI] 0.6–0.8) with an AVM were younger and had fewer medical comorbidities than patients without AVM. After adjustment for confounders, patients with AVM had lower odds of death (odds ratio [OR] 0.5, 95% CI 0.4–0.7) and higher odds of home discharge (OR 2.0, 95% CI 1.4–3.0) than patients without AVM. In a confirmatory analysis of 342 patients with ICH at our institution, the 34 patients (9.9%, 95% CI 7.2–13.6) with a ruptured AVM had higher odds of ambulatory independence at discharge (OR 4.4, 95% CI 1.4–13.1) compared to patients without AVM.Conclusions:Patients with ICH due to ruptured AVM have more favorable outcomes than patients with ICH from other causes.

Abstract TMP110: Outcomes After Intracerebral Hemorrhage in Patients With Arteriovenous Malformations

Stroke ◽  
2017 ◽  
Vol 48 (suppl_1) ◽  
Author(s):  
Santosh Murthy ◽  
Alexander E Merkler ◽  
Setareh S Omran ◽  
Gino Gialdini ◽  
Costantino Iadecola ◽  
...  
Keyword(s):  
Intracerebral Hemorrhage ◽  
Medical Center ◽  
Predictor Variable ◽  
Population Level ◽  
International Classification Of Diseases ◽  
Population Based ◽  
Medical Comorbidities ◽  
Home Discharge ◽  
Ruptured Avm ◽  
Confirmatory Analysis

Background: Few population-level data exist regarding functional outcomes after intracerebral hemorrhage (ICH) caused by a ruptured cerebral arteriovenous malformation (AVM). Our aim was to compare outcomes after ICH from AVM rupture versus other causes of ICH. Methods: We performed a retrospective population-based study using data from the Nationwide Inpatient Sample (NIS), a nationally representative survey of hospitalizations across the U.S. We used previously validated International Classification of Diseases, 9 th Revision, Clinical Modification ( ICD-9-CM ) diagnosis codes to identify ICH cases in the NIS from 2002 through 2011. We also performed a confirmatory analysis in a prospective cohort of patients hospitalized with ICH at our medical center from 2011 through 2015. Our predictor variable was a documented AVM. Our primary outcomes were inpatient mortality and home discharge. We used logistic regression to compare outcomes between ICH patients with and without AVM, while adjusting for demographics and medical comorbidities. In the confirmatory analysis of ICH patients at our institution, we additionally adjusted for hematoma size, hematoma location, and the Glasgow Coma Scale score. Results: Among 619,167 ICH patients in the NIS, the 4,485 patients (0.7%) with an AVM were younger and had fewer medical comorbidities than patients without AVM. After adjustment for demographics and comorbidities, patients with AVM had lower odds of death (odds ratio [OR], 0.53; 95% confidence interval [CI], 0.40-0.71) and higher odds of home discharge (OR, 2.03; 95% CI, 1.38-2.98) than patients without AVM. In a confirmatory analysis of 342 ICH patients at our institution, the 34 patients (9.9%) with a ruptured AVM had significantly higher odds of independent ambulation at discharge (OR, 4.39, 95% CI, 1.47-13.06) compared to ICH patients without AVM. Conclusion: Patients with ICH due to ruptured AVM have more favorable outcomes than patients with other causes of ICH, even after adjustment for demographics, comorbidities, and traditional measures of ICH severity.

scholarly journals Humidifier Disinfectant Consumption and Humidifier Disinfectant-Associated Lung Injury in South Korea: A Nationwide Population-Based Study

2021 ◽  
Vol 18 (11) ◽  
pp. 6136
Author(s):  
Jeonggyo Yoon ◽  
Minsun Kang ◽  
Jaehun Jung ◽  
Min Jae Ju ◽  
Sung Hwan Jeong ◽  
...  
Keyword(s):  
Health Insurance ◽  
Lung Injury ◽  
National Health Insurance ◽  
Population Based ◽  
Annual Number ◽  
Population Based Study ◽  
Annual Consumption ◽  
Using Data ◽  
Water Tanks ◽  
Biocidal Product

Humidifier disinfectant (HD) is a household biocidal product used in humidifier water tanks to prevent the growth of microorganisms. In 2011, a series of lung injury cases of unknown causes emerged in children and pregnant women who had used HD in Korea. This study investigated changes in the nationwide number of cases of humidifier disinfectant-associated lung injury (HDLI) in concordance with nationwide HD consumption using data covering the entire Korean population. More than 25 kinds of HD products were sold between 1994 and 2011. The number of diagnosed HDLI, assessed by S27.3 (other injuries of lungs) of the Korea National Health Insurance Service (NHIS) data, sharply increased by 2005, subsequently decreased after 2005, and almost disappeared after 2011 in concordance with the annual number of HD sales. The number of self-reported HDLIs, assessed using data from all suspected HDLI cases registered in the Korea Ministry of Environment, changed with the annual number of HD sales, with a delay pattern, potentially induced by the late awareness of lung injury diseases. The present study suggests that changes in the nationwide annual consumption of HD products were consistent with changes in the annual number of HDLI cases in Korea.

scholarly journals Prevalence of self-medication in Brazil and associated factors

2016 ◽  
Vol 50 (suppl 2) ◽  
Author(s):  
Paulo Sérgio Dourado Arrais ◽  
Maria Eneida Porto Fernandes ◽  
Tatiane da Silva Dal Pizzol ◽  
Luiz Roberto Ramos ◽  
Sotero Serrate Mengue ◽  
...  
Keyword(s):  
Associated Factors ◽  
Population Based ◽  
Use Of Self ◽  
Self Medication ◽  
Cross Sectional ◽  
Population Based Study ◽  
The North ◽  
Using Data ◽  
Prevalence Ratios ◽  
Use Of Health Services

ABSTRACT OBJECTIVE To analyze the prevalence and associated factors regarding the use of medicines by self-medication in Brazil. METHODS This cross-sectional population-based study was conducted using data from the PNAUM (National Survey on Access, Use and Promotion of Rational Use of Medicines), collected between September 2013 and February 2014 by interviews at the homes of the respondents. All people who reported using any medicines not prescribed by a doctor or dentist were classified as self-medication practitioners. Crude and adjusted prevalence ratios (Poisson regression) and their respective 95% confidence intervals were calculated in order to investigate the factors associated with the use of self-medication by medicines. The independent variables were: sociodemographic characteristics, health conditions and access to and use of health services. In addition, the most commonly consumed medicines by self-medication were individually identified. RESULTS The self-medication prevalence in Brazil was 16.1% (95%CI 15.0–17.5), with it being highest in the Northeast region (23.8%; 95%CI 21.6–26.2). Following the adjusted analysis, self-medication was observed to be associated with females, inhabitants from the North, Northeast and Midwest regions and individuals that have had one, or two or more chronic diseases. Analgesics and muscle relaxants were the therapeutic groups most used for self-medication, with dipyrone being the most consumed medicines. In general, most of the medicines used for self-medication were classified as non-prescriptive (65.5%). CONCLUSIONS Self-medication is common practice in Brazil and mainly involves the use of non-prescription medicines; therefore, the users of such should be made aware of the possible risks.

scholarly journals Estimating malaria burden among pregnant women using data from antenatal care centres in Tanzania: a population-based study

2019 ◽  
Vol 7 (12) ◽  
pp. e1695-e1705 ◽  
Author(s):  
Chonge Kitojo ◽  
Julie R Gutman ◽  
Frank Chacky ◽  
Emmanuel Kigadye ◽  
Sigsbert Mkude ◽  
...  
Keyword(s):  
Antenatal Care ◽  
Pregnant Women ◽  
Population Based ◽  
Population Based Study ◽  
Malaria Burden ◽  
Using Data

Declining incidence of intracerebral hemorrhage over two decades in a population-based study

2016 ◽  
Vol 23 (11) ◽  
pp. 1627-1634 ◽  
Author(s):  
S. Sacco ◽  
R. Ornello ◽  
D. Degan ◽  
C. Tiseo ◽  
F. Pistoia ◽  
...  
Keyword(s):  
Intracerebral Hemorrhage ◽  
Population Based ◽  
Population Based Study

scholarly journals Occupational exposure to solvents and lung function decline: A population based study

Thorax ◽  
2019 ◽  
Vol 74 (7) ◽  
pp. 650-658 ◽  
Author(s):  
Sheikh M Alif ◽  
Shyamali Dharmage ◽  
Geza Benke ◽  
Martine Dennekamp ◽  
John Burgess ◽  
...  
Keyword(s):  
Lung Function ◽  
Occupational Exposures ◽  
Population Based ◽  
Cumulative Exposure ◽  
Health Study ◽  
Lung Function Decline ◽  
Cross Sectional ◽  
Population Based Study ◽  
Aromatic Solvents ◽  
Using Data

RationaleWhile cross-sectional studies have shown associations between certain occupational exposures and lower levels of lung function, there was little evidence from population-based studies with repeated lung function measurements.ObjectivesWe aimed to investigate the associations between occupational exposures and longitudinal lung function decline in the population-based Tasmanian Longitudinal Health Study.MethodsLung function decline between ages 45 years and 50 years was assessed using data from 767 participants. Using lifetime work history calendars completed at age 45 years, exposures were assigned according to the ALOHA plus Job Exposure Matrix. Occupational exposures were defined as ever exposed and cumulative exposure -unit- years. We investigated effect modification by sex, smoking and asthma status.ResultsCompared with those without exposure, ever exposures to aromatic solvents and metals were associated with a greater decline in FEV1 (aromatic solvents 15.5 mL/year (95% CI −24.8 to 6.3); metals 11.3 mL/year (95% CI −21.9 to – 0.7)) and FVC (aromatic solvents 14.1 mL/year 95% CI −28.8 to – 0.7; metals 17.5 mL/year (95% CI –34.3 to – 0.8)). Cumulative exposure (unit years) to aromatic solvents was also associated with greater decline in FEV1 and FVC. Women had lower cumulative exposure years to aromatic solvents than men (mean (SD) 9.6 (15.5) vs 16.6 (14.6)), but greater lung function decline than men. We also found association between ever exposures to gases/fumes or mineral dust and greater decline in lung function.ConclusionsExposures to aromatic solvents and metals were associated with greater lung function decline. The effect of aromatic solvents was strongest in women. Preventive strategies should be implemented to reduce these exposures in the workplace.

scholarly journals A Population-Based Study of Intracerebral Hemorrhage Survivors’ Outcomes

2019 ◽  
Vol 28 (1) ◽  
pp. 49-55 ◽  
Author(s):  
Julius Griauzde ◽  
Lynda D. Lisabeth ◽  
Chengwei Li ◽  
Brisa N. Sanchez ◽  
Erin Case ◽  
...  
Keyword(s):  
Intracerebral Hemorrhage ◽  
Population Based ◽  
Population Based Study

scholarly journals Population-Based Study of Risk of AKI with Levetiracetam

2018 ◽  
Vol 14 (1) ◽  
pp. 17-26 ◽  
Author(s):  
Kevin Yau ◽  
Jorge G. Burneo ◽  
Racquel Jandoc ◽  
Eric McArthur ◽  
Flory Tsobo Muanda ◽  
...  
Keyword(s):  
Confidence Interval ◽  
Serum Creatinine ◽  
Odds Ratio ◽  
Primary Outcome ◽  
Case Reports ◽  
Population Based ◽  
Regulatory Agencies ◽  
Population Based Study ◽  
Outpatient Prescription ◽  
Diagnosis Codes

Background and objectivesRegulatory agencies warn about the risk of AKI with levetiracetam use on the basis of information from case reports. We conducted this study to determine whether new levetiracetam use versus nonuse is associated with a higher risk of AKI.Design, setting, participants, & measurementsThis was a population-based retrospective cohort study of adults with epilepsy in Ontario, Canada. Patients who received a new outpatient prescription for levetiracetam between January 1, 2004 and March 1, 2017 were matched to two nonusers on stage of CKD, recorded seizure in the prior 90 days, and logit of a propensity score for levetiracetam use. The primary outcome was a hospital encounter (emergency department visit or hospitalization) with AKI within 30 days of cohort entry. Secondary outcomes were AKI within 180 days and change in the concentration of serum creatinine. We assessed the primary outcome using health care diagnosis codes. We evaluated the change in the concentration of serum creatinine in a subpopulation with laboratory measurements.ResultsWe matched 3980 levetiracetam users to 7960 nonusers (mean age 55 years, 51% women). Levetiracetam use was not significantly associated with a higher risk of AKI within 30 days (13 [0.33%] events in levetiracetam users and 21 [0.26%] events in nonusers [odds ratio, 1.24; 95% confidence interval, 0.62 to 2.47]). Similarly, there was no significant association with AKI within 180 days (odds ratio, 0.70; 95% confidence interval, 0.43 to 1.13). The change in the concentration of serum creatinine did not significantly differ between levetiracetam users and nonusers.ConclusionsIn this population-based study levetiracetam use was not associated with a higher risk of AKI.PodcastThis article contains a podcast at https://www.asn-online.org/media/podcast/CJASN/2018_12_11_Yau_Podcast.mp3

Nosocomial Infections and Outcomes after Intracerebral Hemorrhage: A Population-Based Study

2016 ◽  
Vol 25 (2) ◽  
pp. 178-184 ◽  
Author(s):  
Santosh B. Murthy ◽  
Yogesh Moradiya ◽  
Jharna Shah ◽  
Alexander E. Merkler ◽  
Halinder S. Mangat ◽  
...  
Keyword(s):  
Intracerebral Hemorrhage ◽  
Nosocomial Infections ◽  
Population Based ◽  
Population Based Study
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