scholarly journals Occupational exposure to solvents and lung function decline: A population based study

Thorax ◽  
2019 ◽  
Vol 74 (7) ◽  
pp. 650-658 ◽  
Author(s):  
Sheikh M Alif ◽  
Shyamali Dharmage ◽  
Geza Benke ◽  
Martine Dennekamp ◽  
John Burgess ◽  
...  
Keyword(s):  
Lung Function ◽  
Occupational Exposures ◽  
Population Based ◽  
Cumulative Exposure ◽  
Health Study ◽  
Lung Function Decline ◽  
Cross Sectional ◽  
Population Based Study ◽  
Aromatic Solvents ◽  
Using Data

RationaleWhile cross-sectional studies have shown associations between certain occupational exposures and lower levels of lung function, there was little evidence from population-based studies with repeated lung function measurements.ObjectivesWe aimed to investigate the associations between occupational exposures and longitudinal lung function decline in the population-based Tasmanian Longitudinal Health Study.MethodsLung function decline between ages 45 years and 50 years was assessed using data from 767 participants. Using lifetime work history calendars completed at age 45 years, exposures were assigned according to the ALOHA plus Job Exposure Matrix. Occupational exposures were defined as ever exposed and cumulative exposure -unit- years. We investigated effect modification by sex, smoking and asthma status.ResultsCompared with those without exposure, ever exposures to aromatic solvents and metals were associated with a greater decline in FEV1 (aromatic solvents 15.5 mL/year (95% CI −24.8 to 6.3); metals 11.3 mL/year (95% CI −21.9 to – 0.7)) and FVC (aromatic solvents 14.1 mL/year 95% CI −28.8 to – 0.7; metals 17.5 mL/year (95% CI –34.3 to – 0.8)). Cumulative exposure (unit years) to aromatic solvents was also associated with greater decline in FEV1 and FVC. Women had lower cumulative exposure years to aromatic solvents than men (mean (SD) 9.6 (15.5) vs 16.6 (14.6)), but greater lung function decline than men. We also found association between ever exposures to gases/fumes or mineral dust and greater decline in lung function.ConclusionsExposures to aromatic solvents and metals were associated with greater lung function decline. The effect of aromatic solvents was strongest in women. Preventive strategies should be implemented to reduce these exposures in the workplace.

scholarly journals Smoking, telomere length and lung function decline: a longitudinal population-based study

Thorax ◽  
2017 ◽  
Vol 73 (3) ◽  
pp. 283-285 ◽  
Author(s):  
Pascal Andujar ◽  
Dominique Courbon ◽  
Emilie Bizard ◽  
Elisabeth Marcos ◽  
Serge Adnot ◽  
...  
Keyword(s):  
Lung Function ◽  
Telomere Length ◽  
Respiratory Health ◽  
Population Based ◽  
Lung Function Decline ◽  
Cross Sectional ◽  
Population Based Study ◽  
Heavy Smoking ◽  
Impaired Lung Function

Telomere shortening is associated with COPD and impaired lung function in cross-sectional studies, but there is no longitudinal study. We used data from 448 participants recruited as part of the French follow-up of the European Community Respiratory Health Survey. We found no relationship between telomere length at baseline and FEV1 decline after 11 years of follow-up. However, heavy smoking was associated with an accelerated FEV1 decline in individuals with short telomeres, but not in subjects with longer telomeres (p for interaction p=0.08). Our findings suggest that short telomere length in peripheral leucocytes might be a marker for increased susceptibility to the effect of smoking.

scholarly journals Prevalence of self-medication in Brazil and associated factors

2016 ◽  
Vol 50 (suppl 2) ◽  
Author(s):  
Paulo Sérgio Dourado Arrais ◽  
Maria Eneida Porto Fernandes ◽  
Tatiane da Silva Dal Pizzol ◽  
Luiz Roberto Ramos ◽  
Sotero Serrate Mengue ◽  
...  
Keyword(s):  
Associated Factors ◽  
Population Based ◽  
Use Of Self ◽  
Self Medication ◽  
Cross Sectional ◽  
Population Based Study ◽  
The North ◽  
Using Data ◽  
Prevalence Ratios ◽  
Use Of Health Services

ABSTRACT OBJECTIVE To analyze the prevalence and associated factors regarding the use of medicines by self-medication in Brazil. METHODS This cross-sectional population-based study was conducted using data from the PNAUM (National Survey on Access, Use and Promotion of Rational Use of Medicines), collected between September 2013 and February 2014 by interviews at the homes of the respondents. All people who reported using any medicines not prescribed by a doctor or dentist were classified as self-medication practitioners. Crude and adjusted prevalence ratios (Poisson regression) and their respective 95% confidence intervals were calculated in order to investigate the factors associated with the use of self-medication by medicines. The independent variables were: sociodemographic characteristics, health conditions and access to and use of health services. In addition, the most commonly consumed medicines by self-medication were individually identified. RESULTS The self-medication prevalence in Brazil was 16.1% (95%CI 15.0–17.5), with it being highest in the Northeast region (23.8%; 95%CI 21.6–26.2). Following the adjusted analysis, self-medication was observed to be associated with females, inhabitants from the North, Northeast and Midwest regions and individuals that have had one, or two or more chronic diseases. Analgesics and muscle relaxants were the therapeutic groups most used for self-medication, with dipyrone being the most consumed medicines. In general, most of the medicines used for self-medication were classified as non-prescriptive (65.5%). CONCLUSIONS Self-medication is common practice in Brazil and mainly involves the use of non-prescription medicines; therefore, the users of such should be made aware of the possible risks.

scholarly journals The prevalence of chronic pain and pain-related interference in the Canadian population from 1994 to 2008

2011 ◽  
Vol 31 (4) ◽  
pp. 157-164 ◽  
Author(s):  
ML Reitsma ◽  
JE Tranmer ◽  
DM Buchanan ◽  
EG Vandenkerkhof
Keyword(s):  
Chronic Pain ◽  
Health Survey ◽  
Canadian Community Health Survey ◽  
Population Based ◽  
Cross Sectional ◽  
Population Based Study ◽  
Canadian Population ◽  
Community Health Survey ◽  
Prevalence Of Pain ◽  
Using Data

Introduction Estimates of the prevalence of chronic pain worldwide and in Canada are inconsistent. Our primary objectives were to determine the prevalence of chronic pain by sex and age and to determine the prevalence of pain-related interference for Canadian men and women between 1994 and 2008. Methods Using data from seven cross-sectional cycles in the National Population Health Survey and the Canadian Community Health Survey, we defined two categorical outcomes, chronic pain and pain-related interference with activities. Results Prevalence of chronic pain ranged from 15.1% in 1996/97 to 18.9% in 1994/95. Chronic pain was most prevalent among women (range: 16.5% to 21.5%), and in the oldest (65 years plus) age group (range: 23.9% to 31.3%). Women aged 65 years plus consistently reported the highest prevalence of chronic pain (range: 26.0% to 34.2%). The majority of adult Canadians who reported chronic pain also reported at least a few activities prevented due to this pain (range: 11.4% to 13.3% of the overall population). Conclusion Similar to international estimates, this Canadian population-based study confirms that chronic pain persists and impacts daily activities. Further study with more detailed definitions of pain and pain-related interference is warranted.

scholarly journals Lung function changes over 8 years and testosterone markers in both sexes: UK Biobank

2020 ◽  
Vol 6 (3) ◽  
pp. 00070-2020
Author(s):  
Alexandra Lenoir ◽  
Elaine Fuertes ◽  
Francisco Gómez-Real ◽  
Benedicte Leynaert ◽  
Diana A. van der Plaat ◽  
...  
Keyword(s):  
Lung Function ◽  
Free Testosterone ◽  
Population Based ◽  
Forced Expiratory Volume ◽  
Sex Hormone Binding Globulin ◽  
Total Testosterone ◽  
Uk Biobank ◽  
Lung Function Decline ◽  
Cross Sectional ◽  
Physically Active

Higher levels of testosterone have been associated with better lung function in cross-sectional population-based studies. The role of testosterone in lung function in women and in lung function decline in men or women is unclear.We studied 5114 men and 5467 women in the UK Biobank with high-quality spirometry at baseline (2006–2010) and 8.4 years later. We studied cross-sectional associations of total testosterone (TT), calculated free testosterone (cFT), free androgen index (FAI) and sex hormone-binding globulin (SHBG) with forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and FEV1/FVC using linear regression and associations of baseline markers with lung function decline using linear mixed-effects regression.Men with higher levels of TT had higher FEV1 (27.56 mL per interquartile range increase TT, 95% CI 5.43–49.68) and FVC (48.06 mL, 95% CI 22.07–74.06) at baseline. Higher cFT levels were associated with higher FEV1 and FVC among physically active men only. In women, higher FAI and cFT levels were associated with lower lung function at baseline and higher levels of TT, cFT and FAI were associated with slightly attenuated FEV1 and FVC decline. Higher levels of SHBG were associated with better lung function in both sexes but slightly accelerated decline in men.In this population-based sample, higher levels of TT were associated with better lung function in men and higher levels of cFT with better lung function in physically active men. A small attenuation of lung function decline with higher levels of TT, cFT and FAI was seen in women only.

scholarly journals LuftiBus in the school (LUIS): a population-based study on respiratory health in schoolchildren

2020 ◽  
Author(s):  
Rebeca Mozun ◽  
Claudia E. Kuehni ◽  
Eva S. L. Pedersen ◽  
Myrofora Goutaki ◽  
Johanna M. Kurz ◽  
...  
Keyword(s):  
Lung Function ◽  
Respiratory Health ◽  
Environmental Exposures ◽  
Population Based ◽  
Cross Sectional ◽  
Population Based Study ◽  
Related Data ◽  
School Head ◽  
Single Breath ◽  
Set Up

SummaryRespiratory disease is common in children and strongly associated with lifestyle and environmental exposures. Thus, it is important to study the epidemiology locally. LuftiBus in the school (LUIS) was set up to assess the respiratory health of schoolchildren in the canton of Zurich, Switzerland.LUIS is a cross-sectional population-based study that was carried out 2013 to 2016. Children aged 6-17 years living in the canton of Zurich were eligible to participate. All schools in the canton were approached and the school head decided whether the school would participate and with which classes. Consenting parents answered a standardized questionnaire at home and assenting children completed a shorter questionnaire by interview at school. Trained technicians measured children’s lung function including spirometry, double tracer gas single-breath washout (DTG-SBW) and fractional exhaled nitric oxide (FeNO). Address histories of participants were geocoded to be linked with area-based socioeconomic measures and environmental exposures like spatiotemporal air pollution estimates for specific time periods and locations. A subgroup was seen again 12 months later using the same procedures to collect longitudinal data.The study included 3870 children at baseline and 655 at the one-year follow-up. Median age was 12.7 years; 281 (8%) had wheezed in the past year. At baseline we collected 3457 (89%) parental and 3546 (92%) children’s questionnaires, and 3393 (88%) FeNO, 3446 (89%) spirometry, and 1795 (46%) DTG-SBW measurements.LUIS is a rich resource of health-related data, with information on lung function, environmental exposures and respiratory health on Swiss schoolchildren.Take home messageLuftiBus in the school (LUIS) is a population-based study with detailed lung function data and rich information on respiratory health in Swiss schoolchildren.

scholarly journals Dietary Phytochemical Index and Psychological Disorders in a large sample of Iranian adults: a population-based study

2020 ◽  
Author(s):  
zahra darabi ◽  
azam Ahmadi Vasmehjani ◽  
amin Salehi-Abargouei ◽  
masoud mirzaei ◽  
Mahdieh Hosseinzadeh
Keyword(s):  
Population Based ◽  
Cross Sectional Study ◽  
Normal Weight ◽  
Health Study ◽  
Cross Sectional ◽  
Population Based Study ◽  
Large Sample ◽  
Symptoms Of Depression ◽  
Obese Subjects ◽  
Apparent Association

Abstract Background: Intake of plant foods including of Phytochemicals may be decrease risk of mental health.Aim: This study aim to investigate association of Dietary Phytochemical Index)DPI( with symptoms of depression, anxiety and stress in a large sample of Iranian adults.Methods: In this cross-sectional study, a total of 7385 adult aged 20-50 years old were provided from the recruitment phase of Yazd Health Study, a population-based cohort research on Iranian adults. Food intakes were assessed via validated and reliable food frequency questionnaire. Symptoms of depression, anxiety and stress were assessed using a validated Depression, Anxiety and Stress Scales questionnaires with 21-items. DPI was calculated by percent of daily energy intake taken from phytochemical-rich foods.Results: After adjusting for potential confounders, normal weight subjects in the highest tertile of DPI had a lower risk of depression (OR: 0.65; 95% CI: 0.44–0.97) and anxiety symptoms (OR: 0.65; 95% CI: 0.45–0.93) compared with those in the lowest tertile. However, no apparent association was found between depression, anxiety and stress in overweight and obese subjects. Conclusion: We found significant association between DPI and mental health in normal weight adults. Prospective studies are required to approve these conclusions.

scholarly journals Increased C-reactive protein levels in participants with frequent headache. The HUNT Study 2006-2008

2019 ◽  
Author(s):  
Knut Hagen ◽  
Lars Jacob Stovner ◽  
Kristian Bernhard Nilsen ◽  
Bendik Slagsvold Winsvold
Keyword(s):  
Migraine With Aura ◽  
Large Scale ◽  
Population Based ◽  
Health Study ◽  
C Reactive Protein ◽  
Cross Sectional ◽  
Population Based Study ◽  
Reactive Protein ◽  
Scale Population ◽  
Hs Crp

Abstract Background Increased high sensitivity C- reactive protein (hs-CRP) levels have been found in many earlier studies on migraine, and recently also in persons with migraine and insomnia. The aim of this study was to see whether these findings could be reproduced in a large-scale population-based study. Methods A total of 50,807 (54%) out of 94,194 invited aged ≥ 20 years or older participated in the third wave of the Nord-Trøndelag Health Study study performed in 2006-2008. Among these, 38,807 (41%) had valid measures of hs-CRP and answered questions on headache and insomnia. Elevated hs-CRP was defined as >3.0 mg/L. The cross-sectional association with headache was estimated by multivariate analyses using multiple logistic regression. The precision of the odds ratio (OR) was assessed with 95% confidence interval (CI). Results In the fully adjusted model, elevated hs-CRP was associated with migraine (OR 1.14, 95% CI 1.04-1.25) and migraine with aura (OR 1.15, 95% CI 1.03-1.29). The association was stronger among individuals with headache ≥ 7 days/month for any headache (OR 1.19, 95% CI 1.08-1.31), migraine (OR 1.30, 95% CI 1.10-1.54), migraine with aura (OR 1.47, 95% CI 1.20-1.80), and other headaches (OR 1.16, 95% CI 1.03-1.30). No clear relationship was found between elevated hs-CRP and headache less than 7 days/month or with insomnia. Conclusions Cross-sectional data from a large-scale population-based study showed that elevated hs-CRP was associated with headache ≥ 7 days/month, especially frequent migraine with aura.

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